Entry euk:J3KR51_HUMAN

ID   J3KR51_HUMAN            Unreviewed;       479 AA.
AC   J3KR51;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   10-MAY-2017, entry version 44.
DE   SubName: Full=HCG1787564 {ECO:0000313|EMBL:EAW72133.1};
DE   SubName: Full=Zinc finger protein 525 {ECO:0000313|Ensembl:ENSP00000417696};
GN   Name=ZNF525 {ECO:0000313|Ensembl:ENSP00000417696};
GN   ORFNames=hCG_1787564 {ECO:0000313|EMBL:EAW72133.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417696, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|EMBL:EAW72133.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000417696, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3] {ECO:0000313|EMBL:EAW72133.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000417696}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC010467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC125388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471135; EAW72133.1; -; Genomic_DNA.
DR   RefSeq; NP_001335085.1; NM_001348156.1.
DR   UniGene; Hs.352638; -.
DR   STRING; 9606.ENSP00000417696; -.
DR   Ensembl; ENST00000474037; ENSP00000417696; ENSG00000203326.
DR   GeneID; 170958; -.
DR   UCSC; uc061cjl.1; human.
DR   HGNC; HGNC:29423; ZNF525.
DR   OpenTargets; ENSG00000203326; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00690000102079; -.
DR   OMA; LSELHIF; -.
DR   OrthoDB; EOG091G02KC; -.
DR   TreeFam; TF341892; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000203326; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01352; KRAB; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00780264};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KR51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00780289};
KW   Zinc {ECO:0000256|SAAS:SAAS00780264};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00780264}.
FT   DOMAIN        8     81       KRAB. {ECO:0000259|PROSITE:PS50805}.
FT   DOMAIN      215    242       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      243    270       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      271    298       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      299    326       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      327    354       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      355    382       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      383    410       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      411    438       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      439    466       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       243    265       ismart:ZnF_C2H2 [T]
FT   MYHIT       301    321       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       327    349       ismart:ZnF_C2H2 [T]
FT   MYHIT       215    237       ismart:ZnF_C2H2 [T]
FT   MYHIT       357    377       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       383    405       ismart:ZnF_C2H2 [T]
FT   MYHIT       413    433       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       355    377       ismart:ZnF_C2H2 [T]
FT   MYHIT         8     70       ismart:KRAB [T]
FT   MYHIT       411    438       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       299    321       ismart:ZnF_C2H2 [T]
FT   MYHIT       411    433       ismart:ZnF_C2H2 [T]
FT   MYHIT       355    382       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       439    466       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       327    354       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       441    461       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       299    326       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       215    242       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       385    405       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       439    461       ismart:ZnF_C2H2 [T]
FT   MYHIT       243    270       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       383    410       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       271    293       ismart:ZnF_C2H2 [T]
FT   MYHIT       273    293       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       271    298       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT         7     48       ipfam:KRAB [T]
FT   MYHIT       329    349       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       245    265       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT         8     81       iprf:KRAB [T]
SQ   SEQUENCE   479 AA;  56029 MW;  DDAB64AAC66FB81E CRC64;
     MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIS SKCTMKEFSS
     TAQGNTEVIH TGTLQRHERH HIGDFSFQEI EKDIHNFEFQ WQEDERNGHE APMTKIKKLM
     GSTEQYDHRH AGNKPIKYQL GSSFHSHLSE LHIFQPKGKI NNQVEKSIND ASSVSTAQRI
     SCRPKTHISN NYGDNFLNYS LLTQRQEVRM REKSFQCIES GKAFNYSSLL RKHQIIHLGE
     KQYKCDVCDK VFIRKRYLAR HRRCHTGEKP YKCNECGKSF SQMSSLTYHH RLHTGEKPYK
     CEECDKAFRH NSALQRHRRI HTGEKPHKCN ECGKTFSQKS YLACHRSIHT GKKPYECEEC
     DKAFSFKSNL ESHRITHTGE KPYKCNDCGK TFSHMSTLTC HRRLHTGEKP YKCEECDEAF
     RFKSSLERHR RIHNGEKLYK CNECGKTFSQ ELSLTCHCRL HSGEKPCKCG ECDKAYSFK
//