ID J3KNR3_HUMAN Unreviewed; 258 AA.
AC J3KNR3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 10-MAY-2017, entry version 39.
DE SubName: Full=G protein-coupled receptor 103, isoform CRA_a {ECO:0000313|EMBL:EAX05261.1};
DE SubName: Full=Pyroglutamylated RFamide peptide receptor {ECO:0000313|Ensembl:ENSP00000335610};
GN Name=QRFPR {ECO:0000313|Ensembl:ENSP00000335610};
GN Synonyms=GPR103 {ECO:0000313|EMBL:EAX05261.1};
GN ORFNames=hCG_1778361 {ECO:0000313|EMBL:EAX05261.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000335610, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|EMBL:EAX05261.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2] {ECO:0000313|Ensembl:ENSP00000335610, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [3] {ECO:0000313|EMBL:EAX05261.1}
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSP00000335610}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2012) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AC093816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471056; EAX05261.1; -; Genomic_DNA.
DR UniGene; Hs.368977; -.
DR STRING; 9606.ENSP00000377948; -.
DR Ensembl; ENST00000334383; ENSP00000335610; ENSG00000186867.
DR UCSC; uc003ids.3; human.
DR HGNC; HGNC:15565; QRFPR.
DR OpenTargets; ENSG00000186867; -.
DR eggNOG; KOG3656; Eukaryota.
DR eggNOG; ENOG410XRW9; LUCA.
DR GeneTree; ENSGT00760000118781; -.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000186867; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46 70 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82 103 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123 141 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 162 181 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 62 228 G_PROTEIN_RECEP_F1_2.
FT {ECO:0000259|PROSITE:PS50262}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 62 228 ipfam:7tm_1 [T]
FT MYHIT 62 228 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 131 147 ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ SEQUENCE 258 AA; 29426 MW; EBFEDE2D0A0B6612 CRC64;
MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL
FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM
VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM
WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMEE ETSCHYDGDS
GGSLCCVLGT IPCCPYDD
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