ID IF172_MOUSE Reviewed; 1749 AA.
AC Q6VH22; Q6NZK1; Q80TI4; Q80W19; Q9DAB0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 10-MAY-2017, entry version 115.
DE RecName: Full=Intraflagellar transport protein 172 homolog;
DE AltName: Full=Protein wimple;
GN Name=Ift172; Synonyms=Kiaa1179, Wim;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND MUTAGENESIS OF
RP LEU-1564.
RC STRAIN=C57BL/6J;
RX PubMed=14603322; DOI=10.1038/nature02061;
RA Huangfu D., Liu A., Rakeman A.S., Murcia N.S., Niswander L.,
RA Anderson K.V.;
RT "Hedgehog signalling in the mouse requires intraflagellar transport
RT proteins.";
RL Nature 426:83-87(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 660-1749 (ISOFORM 1).
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT II. The complete nucleotide sequences of 400 mouse KIAA-homologous
RT cDNAs identified by screening of terminal sequences of cDNA clones
RT randomly sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP INTERACTION WITH IFT88.
RX PubMed=11062270; DOI=10.1083/jcb.151.3.709;
RA Pazour G.J., Dickert B.L., Vucica Y., Seeley E.S., Rosenbaum J.L.,
RA Witman G.B., Cole D.G.;
RT "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney
RT disease gene tg737, are required for assembly of cilia and flagella.";
RL J. Cell Biol. 151:709-718(2000).
RN [6]
RP FUNCTION.
RX PubMed=16061793; DOI=10.1073/pnas.0505328102;
RA Huangfu D., Anderson K.V.;
RT "Cilia and Hedgehog responsiveness in the mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11325-11330(2005).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP INTERACTION WITH RABL2, AND TISSUE SPECIFICITY.
RX PubMed=23055941; DOI=10.1371/journal.pgen.1002969;
RA Lo J.C., Jamsai D., O'Connor A.E., Borg C., Clark B.J.,
RA Whisstock J.C., Field M.C., Adams V., Ishikawa T., Aitken R.J.,
RA Whittle B., Goodnow C.C., Ormandy C.J., O'Bryan M.K.;
RT "RAB-like 2 has an essential role in male fertility, sperm intra-
RT flagellar transport, and tail assembly.";
RL PLoS Genet. 8:E1002969-E1002969(2012).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=24339785; DOI=10.1371/journal.pgen.1003960;
RA Kraehling A.M., Alvarez L., Debowski K., Van Q., Gunkel M., Irsen S.,
RA Al-Amoudi A., Struenker T., Kremmer E., Krause E., Voigt I.,
RA Woertge S., Waisman A., Weyand I., Seifert R., Kaupp U.B., Wachten D.;
RT "CRIS-a novel cAMP-binding protein controlling spermiogenesis and the
RT development of flagellar bending.";
RL PLoS Genet. 9:E1003960-E1003960(2013).
RN [10]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-672, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.O113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
RA Vemulapalli V., Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Required for the maintenance and formation of cilia.
CC Plays an indirect role in hedgehog (Hh) signaling, cilia being
CC required for all activity of the hedgehog pathway.
CC {ECO:0000269|PubMed:14603322, ECO:0000269|PubMed:16061793}.
CC -!- SUBUNIT: Interacts with IFT88. Interacts with RABL2/RABL2A; binds
CC preferentially to GDP-bound RABL2. {ECO:0000269|PubMed:11062270,
CC ECO:0000269|PubMed:23055941}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6VH22-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6VH22-2; Sequence=VSP_032850;
CC -!- TISSUE SPECIFICITY: Co-localizes with RABL2/RABL2A in the midpiece
CC of elongated spermatids within the testis (at protein level).
CC Expressed in the flagellum of elongated spermatids and sperm in
CC the testis lumen (at protein level) (PubMed:24339785).
CC {ECO:0000269|PubMed:23055941, ECO:0000269|PubMed:24339785}.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65743.3; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain.; Evidence={ECO:0000305};
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DR EMBL; AY339616; AAR05390.1; -; mRNA.
DR EMBL; AK006007; BAB24362.1; -; mRNA.
DR EMBL; BC051928; AAH51928.1; -; mRNA.
DR EMBL; BC060948; AAH60948.1; -; mRNA.
DR EMBL; BC066096; AAH66096.1; -; mRNA.
DR EMBL; AK122461; BAC65743.3; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS39054.1; -. [Q6VH22-1]
DR RefSeq; NP_080574.5; NM_026298.5. [Q6VH22-1]
DR UniGene; Mm.293023; -.
DR ProteinModelPortal; Q6VH22; -.
DR BioGrid; 212346; 1.
DR STRING; 10090.ENSMUSP00000049335; -.
DR iPTMnet; Q6VH22; -.
DR PhosphoSitePlus; Q6VH22; -.
DR PaxDb; Q6VH22; -.
DR PeptideAtlas; Q6VH22; -.
DR PRIDE; Q6VH22; -.
DR Ensembl; ENSMUST00000041565; ENSMUSP00000049335; ENSMUSG00000038564. [Q6VH22-1]
DR GeneID; 67661; -.
DR KEGG; mmu:67661; -.
DR UCSC; uc008wya.1; mouse. [Q6VH22-2]
DR UCSC; uc008wyb.1; mouse. [Q6VH22-1]
DR CTD; 26160; -.
DR MGI; MGI:2682064; Ift172.
DR eggNOG; KOG3616; Eukaryota.
DR eggNOG; ENOG410XR2C; LUCA.
DR GeneTree; ENSGT00440000033648; -.
DR HOGENOM; HOG000259226; -.
DR HOVERGEN; HBG098449; -.
DR InParanoid; Q6VH22; -.
DR KO; K19676; -.
DR OMA; EDIHLKN; -.
DR OrthoDB; EOG091G02TF; -.
DR PhylomeDB; Q6VH22; -.
DR TreeFam; TF312901; -.
DR Reactome; R-MMU-5620924; Intraflagellar transport.
DR ChiTaRS; Ift172; mouse.
DR PRO; PR:Q6VH22; -.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000038564; -.
DR ExpressionAtlas; Q6VH22; baseline and differential.
DR Genevisible; Q6VH22; MM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:1903561; C:extracellular vesicle; ISO:MGI.
DR GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISO:MGI.
DR GO; GO:0097598; C:sperm cytoplasmic droplet; IDA:MGI.
DR GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR GO; GO:0097228; C:sperm principal piece; IDA:MGI.
DR GO; GO:0060348; P:bone development; IMP:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0001947; P:heart looping; IMP:MGI.
DR GO; GO:0061525; P:hindgut development; IMP:MGI.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome.
DR GO; GO:0070986; P:left/right axis specification; IMP:MGI.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:0001843; P:neural tube closure; IMP:MGI.
DR GO; GO:0021915; P:neural tube development; IMP:MGI.
DR GO; GO:0001841; P:neural tube formation; IMP:MGI.
DR GO; GO:1905515; P:non-motile cilium assembly; IMP:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IMP:MGI.
DR GO; GO:0060021; P:palate development; IMP:MGI.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0016485; P:protein processing; IMP:MGI.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 5.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cilium;
KW Complete proteome; Developmental protein; Isopeptide bond;
KW Methylation; Reference proteome; Repeat; TPR repeat; Ubl conjugation;
KW WD repeat.
FT CHAIN 1 1749 Intraflagellar transport protein 172
FT homolog.
FT /FTId=PRO_0000328942.
FT REPEAT 14 53 WD 1.
FT REPEAT 64 103 WD 2.
FT REPEAT 110 148 WD 3.
FT REPEAT 150 191 WD 4.
FT REPEAT 195 233 WD 5.
FT REPEAT 238 278 WD 6.
FT REPEAT 284 323 WD 7.
FT REPEAT 483 520 WD 8.
FT REPEAT 521 559 WD 9.
FT REPEAT 593 624 TPR 1.
FT REPEAT 692 725 TPR 2.
FT REPEAT 809 842 TPR 3.
FT REPEAT 854 887 TPR 4.
FT REPEAT 912 945 TPR 5.
FT REPEAT 947 970 TPR 6.
FT REPEAT 971 1004 TPR 7.
FT REPEAT 1042 1075 TPR 8.
FT REPEAT 1142 1175 TPR 9.
FT REPEAT 1276 1309 TPR 10.
FT REPEAT 1345 1378 TPR 11.
FT REPEAT 1411 1445 TPR 12.
FT REPEAT 1447 1477 TPR 13.
FT REPEAT 1574 1607 TPR 14.
FT MOD_RES 1 1 N-acetylmethionine.
FT {ECO:0000250|UniProtKB:Q9UG01}.
FT MOD_RES 672 672 Omega-N-methylarginine.
FT {ECO:0000244|PubMed:24129315}.
FT CROSSLNK 4 4 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO1).
FT {ECO:0000250|UniProtKB:Q9UG01}.
FT VAR_SEQ 1 1591 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_032850.
FT MUTAGEN 1564 1564 L->P: In wim; embryos arrest at embryonic
FT day E10.5-11.5 and display an open neural
FT tube in the head that lack the normal
FT groove on the ventral midline. They lack
FT ventral neural cell types and display
FT other phenotypes characteristic of
FT defects in Sonic hedgehog signaling.
FT {ECO:0000269|PubMed:14603322}.
FT CONFLICT 949 949 T -> I (in Ref. 3; AAH66096).
FT {ECO:0000305}.
FT CONFLICT 1506 1506 L -> F (in Ref. 3; AAH51928).
FT {ECO:0000305}.
FT CONFLICT 1511 1511 F -> S (in Ref. 3; AAH66096).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 2 44 ismart:WD40 [T]
FT MYHIT 225 267 ismart:WD40 [T]
FT MYHIT 141 180 ismart:WD40 [T]
FT MYHIT 15 44 ipfam:WD40 [T]
FT MYHIT 186 223 ismart:WD40 [T]
FT MYHIT 279 314 ismart:WD40 [T]
FT MYHIT 102 139 ismart:WD40 [T]
FT MYHIT 55 94 ismart:WD40 [T]
SQ SEQUENCE 1749 AA; 197548 MW; 59277DEBE5B1C1B2 CRC64;
MQLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
PAEYVIVFGL AEGKVRLANT KTNKSSTIYG TESYVVALTT NCSGKGILSG HADGTIVRYF
FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPQE
REFTTAAASP GGQSVVLGSY DRLRVFNWSP RRSIWEEAKP KEIANLYTVT ALAWKRDGSR
LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK SHYGYEVEEV
KILGKERYLV AHTSDTLLLG DLNTNRLSEI AWQGSGGNEK YFFENENVCM IFNAGELTLV
EYGSNDSLGS VRTEFMNPHL ISVRINERCQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG
TISHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYVQ WVPGSDVLVA
QNRNSLCVWY NIEAPERVTM SSIRGDVVGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG
TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHTAERCFSA LGHVAKARFL
HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR
WEECIAVAEA KGHPALEKLR RDYYQWLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
KAARLVLTRE ELLANTELVE HITTALIKGE LYERAGDLFE KIRNPQRALE CYCKGNAFMK
AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
YILDLQDRNT ASKYYPRVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYDDMIRLV
GKHHPDLLSD THLHLGKELE AEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA
HGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEATIDHA ADNCSFEFAF ELSRLAFKHK
APEIHLKYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL
QEEYEREATK KGGRGVEGLV EQARQWEQAG EYSRAVDCYL KVRDSGSSGL MEKCWMKAAE
LSIKFLPPQR SLEVVRVVGP QLIGIGKHSA AAELYLNLDL VKEAIDAFIE GEEWNKAKRV
AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK
ILHKYVALYA THLIREGGYA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNNAEAY
HSWADLRDVL FNLCENLVKS SEANSAAHEE FEMMLLISHY YATRSAAQSI KQLETVAARL
SVSLLRHTQL LPADKAFYEA GTAAKEVGWE NMAFIFLNRF LDLTDAIEEG TLDALDHSDF
QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGVY EASLVAASTG
VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
LPSTSFSFQ
//
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