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DescriptionRecName: Full=Intraflagellar transport protein 172 homolog; AltName: Full=Protein wimple;
MyHits logo
MyHits synonymsIF172_MOUSE , Q6VH22 , Q6NZK1 , Q80TI4 , Q80W19 , Q9DAB0 , 59277DEBE5B1C1B2
match map segment
ismart:WD40 ismart:WD40 ismart:WD40 ismart:WD40 ipfam:WD40 ismart:WD40 ismart:WD40 ismart:WD40  
Legends: 1, N-acetylmethionine. {ECO:0000250|UniProtKB:Q9UG01}; 2, Omega-N-methylarginine. {ECO:0000244|PubMed:24129315}; 3, CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1). {ECO:0000250|UniProtKB:Q9UG01}; 4, MUTAGEN L->P: In wim; embryos arrest at embryonic day E10.5-11.5 and display an open neural tube in the head that lack the normal groove on the ventral midline. They lack ventral neural cell types and display other phenotypes characteristic of defects in Sonic hedgehog signaling. {ECO:0000269|PubMed:14603322}; 5, CONFLICT T -> I (in Ref. 3; AAH66096). {ECO:0000305}; 6, CONFLICT L -> F (in Ref. 3; AAH51928). {ECO:0000305}; 7, CONFLICT F -> S (in Ref. 3; AAH66096). {ECO:0000305}; 8, REPEAT WD 1; 9, REPEAT WD 2; 10, REPEAT WD 3; 11, REPEAT WD 4; 12, REPEAT WD 5; 13, REPEAT WD 6; 14, REPEAT WD 7; 15, REPEAT WD 8; 16, REPEAT WD 9; 17, REPEAT TPR 1; 18, REPEAT TPR 2; 19, REPEAT TPR 3; 20, REPEAT TPR 4; 21, REPEAT TPR 5; 22, REPEAT TPR 6; 23, REPEAT TPR 7; 24, REPEAT TPR 8; 25, REPEAT TPR 9; 26, REPEAT TPR 10; 27, REPEAT TPR 11; 28, REPEAT TPR 12; 29, REPEAT TPR 13; 30, REPEAT TPR 14; 31, ismart:WD40 [T]; 32, ipfam:WD40 [T].
ID   IF172_MOUSE             Reviewed;        1749 AA.
AC   Q6VH22; Q6NZK1; Q80TI4; Q80W19; Q9DAB0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   10-MAY-2017, entry version 115.
DE   RecName: Full=Intraflagellar transport protein 172 homolog;
DE   AltName: Full=Protein wimple;
GN   Name=Ift172; Synonyms=Kiaa1179, Wim;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND MUTAGENESIS OF
RP   LEU-1564.
RC   STRAIN=C57BL/6J;
RX   PubMed=14603322; DOI=10.1038/nature02061;
RA   Huangfu D., Liu A., Rakeman A.S., Murcia N.S., Niswander L.,
RA   Anderson K.V.;
RT   "Hedgehog signalling in the mouse requires intraflagellar transport
RT   proteins.";
RL   Nature 426:83-87(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 660-1749 (ISOFORM 1).
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   II. The complete nucleotide sequences of 400 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [5]
RP   INTERACTION WITH IFT88.
RX   PubMed=11062270; DOI=10.1083/jcb.151.3.709;
RA   Pazour G.J., Dickert B.L., Vucica Y., Seeley E.S., Rosenbaum J.L.,
RA   Witman G.B., Cole D.G.;
RT   "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney
RT   disease gene tg737, are required for assembly of cilia and flagella.";
RL   J. Cell Biol. 151:709-718(2000).
RN   [6]
RP   FUNCTION.
RX   PubMed=16061793; DOI=10.1073/pnas.0505328102;
RA   Huangfu D., Anderson K.V.;
RT   "Cilia and Hedgehog responsiveness in the mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11325-11330(2005).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [8]
RP   INTERACTION WITH RABL2, AND TISSUE SPECIFICITY.
RX   PubMed=23055941; DOI=10.1371/journal.pgen.1002969;
RA   Lo J.C., Jamsai D., O'Connor A.E., Borg C., Clark B.J.,
RA   Whisstock J.C., Field M.C., Adams V., Ishikawa T., Aitken R.J.,
RA   Whittle B., Goodnow C.C., Ormandy C.J., O'Bryan M.K.;
RT   "RAB-like 2 has an essential role in male fertility, sperm intra-
RT   flagellar transport, and tail assembly.";
RL   PLoS Genet. 8:E1002969-E1002969(2012).
RN   [9]
RP   TISSUE SPECIFICITY.
RX   PubMed=24339785; DOI=10.1371/journal.pgen.1003960;
RA   Kraehling A.M., Alvarez L., Debowski K., Van Q., Gunkel M., Irsen S.,
RA   Al-Amoudi A., Struenker T., Kremmer E., Krause E., Voigt I.,
RA   Woertge S., Waisman A., Weyand I., Seifert R., Kaupp U.B., Wachten D.;
RT   "CRIS-a novel cAMP-binding protein controlling spermiogenesis and the
RT   development of flagellar bending.";
RL   PLoS Genet. 9:E1003960-E1003960(2013).
RN   [10]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-672, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=24129315; DOI=10.1074/mcp.O113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
RA   Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
RA   Vemulapalli V., Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- FUNCTION: Required for the maintenance and formation of cilia.
CC       Plays an indirect role in hedgehog (Hh) signaling, cilia being
CC       required for all activity of the hedgehog pathway.
CC       {ECO:0000269|PubMed:14603322, ECO:0000269|PubMed:16061793}.
CC   -!- SUBUNIT: Interacts with IFT88. Interacts with RABL2/RABL2A; binds
CC       preferentially to GDP-bound RABL2. {ECO:0000269|PubMed:11062270,
CC       ECO:0000269|PubMed:23055941}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6VH22-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6VH22-2; Sequence=VSP_032850;
CC   -!- TISSUE SPECIFICITY: Co-localizes with RABL2/RABL2A in the midpiece
CC       of elongated spermatids within the testis (at protein level).
CC       Expressed in the flagellum of elongated spermatids and sperm in
CC       the testis lumen (at protein level) (PubMed:24339785).
CC       {ECO:0000269|PubMed:23055941, ECO:0000269|PubMed:24339785}.
CC   -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65743.3; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain.; Evidence={ECO:0000305};
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DR   EMBL; AY339616; AAR05390.1; -; mRNA.
DR   EMBL; AK006007; BAB24362.1; -; mRNA.
DR   EMBL; BC051928; AAH51928.1; -; mRNA.
DR   EMBL; BC060948; AAH60948.1; -; mRNA.
DR   EMBL; BC066096; AAH66096.1; -; mRNA.
DR   EMBL; AK122461; BAC65743.3; ALT_SEQ; Transcribed_RNA.
DR   CCDS; CCDS39054.1; -. [Q6VH22-1]
DR   RefSeq; NP_080574.5; NM_026298.5. [Q6VH22-1]
DR   UniGene; Mm.293023; -.
DR   ProteinModelPortal; Q6VH22; -.
DR   BioGrid; 212346; 1.
DR   STRING; 10090.ENSMUSP00000049335; -.
DR   iPTMnet; Q6VH22; -.
DR   PhosphoSitePlus; Q6VH22; -.
DR   PaxDb; Q6VH22; -.
DR   PeptideAtlas; Q6VH22; -.
DR   PRIDE; Q6VH22; -.
DR   Ensembl; ENSMUST00000041565; ENSMUSP00000049335; ENSMUSG00000038564. [Q6VH22-1]
DR   GeneID; 67661; -.
DR   KEGG; mmu:67661; -.
DR   UCSC; uc008wya.1; mouse. [Q6VH22-2]
DR   UCSC; uc008wyb.1; mouse. [Q6VH22-1]
DR   CTD; 26160; -.
DR   MGI; MGI:2682064; Ift172.
DR   eggNOG; KOG3616; Eukaryota.
DR   eggNOG; ENOG410XR2C; LUCA.
DR   GeneTree; ENSGT00440000033648; -.
DR   HOGENOM; HOG000259226; -.
DR   HOVERGEN; HBG098449; -.
DR   InParanoid; Q6VH22; -.
DR   KO; K19676; -.
DR   OMA; EDIHLKN; -.
DR   OrthoDB; EOG091G02TF; -.
DR   PhylomeDB; Q6VH22; -.
DR   TreeFam; TF312901; -.
DR   Reactome; R-MMU-5620924; Intraflagellar transport.
DR   ChiTaRS; Ift172; mouse.
DR   PRO; PR:Q6VH22; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000038564; -.
DR   ExpressionAtlas; Q6VH22; baseline and differential.
DR   Genevisible; Q6VH22; MM.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR   GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR   GO; GO:1903561; C:extracellular vesicle; ISO:MGI.
DR   GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISO:MGI.
DR   GO; GO:0097598; C:sperm cytoplasmic droplet; IDA:MGI.
DR   GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR   GO; GO:0097228; C:sperm principal piece; IDA:MGI.
DR   GO; GO:0060348; P:bone development; IMP:MGI.
DR   GO; GO:0007420; P:brain development; IMP:MGI.
DR   GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:MGI.
DR   GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR   GO; GO:0008544; P:epidermis development; IMP:MGI.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   GO; GO:0001947; P:heart looping; IMP:MGI.
DR   GO; GO:0061525; P:hindgut development; IMP:MGI.
DR   GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome.
DR   GO; GO:0070986; P:left/right axis specification; IMP:MGI.
DR   GO; GO:0060173; P:limb development; IMP:MGI.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
DR   GO; GO:0001843; P:neural tube closure; IMP:MGI.
DR   GO; GO:0021915; P:neural tube development; IMP:MGI.
DR   GO; GO:0001841; P:neural tube formation; IMP:MGI.
DR   GO; GO:1905515; P:non-motile cilium assembly; IMP:MGI.
DR   GO; GO:0007219; P:Notch signaling pathway; IMP:MGI.
DR   GO; GO:0060021; P:palate development; IMP:MGI.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:MGI.
DR   GO; GO:0016485; P:protein processing; IMP:MGI.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.
DR   GO; GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
DR   Gene3D; 1.25.40.10; -; 5.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011990; TPR-like_helical_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Cell projection; Cilium;
KW   Complete proteome; Developmental protein; Isopeptide bond;
KW   Methylation; Reference proteome; Repeat; TPR repeat; Ubl conjugation;
KW   WD repeat.
FT   CHAIN         1   1749       Intraflagellar transport protein 172
FT                                homolog.
FT                                /FTId=PRO_0000328942.
FT   REPEAT       14     53       WD 1.
FT   REPEAT       64    103       WD 2.
FT   REPEAT      110    148       WD 3.
FT   REPEAT      150    191       WD 4.
FT   REPEAT      195    233       WD 5.
FT   REPEAT      238    278       WD 6.
FT   REPEAT      284    323       WD 7.
FT   REPEAT      483    520       WD 8.
FT   REPEAT      521    559       WD 9.
FT   REPEAT      593    624       TPR 1.
FT   REPEAT      692    725       TPR 2.
FT   REPEAT      809    842       TPR 3.
FT   REPEAT      854    887       TPR 4.
FT   REPEAT      912    945       TPR 5.
FT   REPEAT      947    970       TPR 6.
FT   REPEAT      971   1004       TPR 7.
FT   REPEAT     1042   1075       TPR 8.
FT   REPEAT     1142   1175       TPR 9.
FT   REPEAT     1276   1309       TPR 10.
FT   REPEAT     1345   1378       TPR 11.
FT   REPEAT     1411   1445       TPR 12.
FT   REPEAT     1447   1477       TPR 13.
FT   REPEAT     1574   1607       TPR 14.
FT   MOD_RES       1      1       N-acetylmethionine.
FT                                {ECO:0000250|UniProtKB:Q9UG01}.
FT   MOD_RES     672    672       Omega-N-methylarginine.
FT                                {ECO:0000244|PubMed:24129315}.
FT   CROSSLNK      4      4       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO1).
FT                                {ECO:0000250|UniProtKB:Q9UG01}.
FT   VAR_SEQ       1   1591       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_032850.
FT   MUTAGEN    1564   1564       L->P: In wim; embryos arrest at embryonic
FT                                day E10.5-11.5 and display an open neural
FT                                tube in the head that lack the normal
FT                                groove on the ventral midline. They lack
FT                                ventral neural cell types and display
FT                                other phenotypes characteristic of
FT                                defects in Sonic hedgehog signaling.
FT                                {ECO:0000269|PubMed:14603322}.
FT   CONFLICT    949    949       T -> I (in Ref. 3; AAH66096).
FT                                {ECO:0000305}.
FT   CONFLICT   1506   1506       L -> F (in Ref. 3; AAH51928).
FT                                {ECO:0000305}.
FT   CONFLICT   1511   1511       F -> S (in Ref. 3; AAH66096).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       279    314       ismart:WD40 [T]
FT   MYHIT       186    223       ismart:WD40 [T]
FT   MYHIT       141    180       ismart:WD40 [T]
FT   MYHIT        55     94       ismart:WD40 [T]
FT   MYHIT        15     44       ipfam:WD40 [T]
FT   MYHIT       225    267       ismart:WD40 [T]
FT   MYHIT         2     44       ismart:WD40 [T]
FT   MYHIT       102    139       ismart:WD40 [T]
SQ   SEQUENCE   1749 AA;  197548 MW;  59277DEBE5B1C1B2 CRC64;
     MQLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
     KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
     PAEYVIVFGL AEGKVRLANT KTNKSSTIYG TESYVVALTT NCSGKGILSG HADGTIVRYF
     FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPQE
     REFTTAAASP GGQSVVLGSY DRLRVFNWSP RRSIWEEAKP KEIANLYTVT ALAWKRDGSR
     LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK SHYGYEVEEV
     KILGKERYLV AHTSDTLLLG DLNTNRLSEI AWQGSGGNEK YFFENENVCM IFNAGELTLV
     EYGSNDSLGS VRTEFMNPHL ISVRINERCQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG
     TISHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYVQ WVPGSDVLVA
     QNRNSLCVWY NIEAPERVTM SSIRGDVVGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG
     TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHTAERCFSA LGHVAKARFL
     HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR
     WEECIAVAEA KGHPALEKLR RDYYQWLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
     KAARLVLTRE ELLANTELVE HITTALIKGE LYERAGDLFE KIRNPQRALE CYCKGNAFMK
     AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
     YILDLQDRNT ASKYYPRVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
     AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYDDMIRLV
     GKHHPDLLSD THLHLGKELE AEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA
     HGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEATIDHA ADNCSFEFAF ELSRLAFKHK
     APEIHLKYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
     EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL
     QEEYEREATK KGGRGVEGLV EQARQWEQAG EYSRAVDCYL KVRDSGSSGL MEKCWMKAAE
     LSIKFLPPQR SLEVVRVVGP QLIGIGKHSA AAELYLNLDL VKEAIDAFIE GEEWNKAKRV
     AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK
     ILHKYVALYA THLIREGGYA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNNAEAY
     HSWADLRDVL FNLCENLVKS SEANSAAHEE FEMMLLISHY YATRSAAQSI KQLETVAARL
     SVSLLRHTQL LPADKAFYEA GTAAKEVGWE NMAFIFLNRF LDLTDAIEEG TLDALDHSDF
     QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGVY EASLVAASTG
     VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
     LPSTSFSFQ
//