ID IF172_HUMAN Reviewed; 1749 AA.
AC Q9UG01; A5PKZ0; B2RNU5; Q86X44; Q96HW4; Q9UFJ9; Q9ULP1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 12-APR-2017, entry version 124.
DE RecName: Full=Intraflagellar transport protein 172 homolog;
GN Name=IFT172; Synonyms=KIAA1179;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-1749 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1203-1737 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 660-1749 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis
RT from size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [6]
RP SUMOYLATION AT LYS-4, AND ACETYLATION AT MET-1.
RC TISSUE=Cervix carcinoma;
RX PubMed=20388717; DOI=10.1074/jbc.M110.106955;
RA Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A.,
RA Eriksson J.E., Sistonen L.;
RT "In vivo identification of sumoylation sites by a signature tag and
RT cysteine-targeted affinity purification.";
RL J. Biol. Chem. 285:19324-19329(2010).
RN [7]
RP SUBCELLULAR LOCATION, AND VARIANTS SRTD10 TRP-296; ASN-411;
RP 464-ASP-ILE-465 DEL; PRO-1536; CYS-1544 AND ARG-1727.
RX PubMed=24140113; DOI=10.1016/j.ajhg.2013.09.012;
RG UK10K Consortium;
RA Halbritter J., Bizet A.A., Schmidts M., Porath J.D., Braun D.A.,
RA Gee H.Y., McInerney-Leo A.M., Krug P., Filhol E., Davis E.E.,
RA Airik R., Czarnecki P.G., Lehman A.M., Trnka P., Nitschke P.,
RA Bole-Feysot C., Schueler M., Knebelmann B., Burtey S., Szabo A.J.,
RA Tory K., Leo P.J., Gardiner B., McKenzie F.A., Zankl A., Brown M.A.,
RA Hartley J.L., Maher E.R., Li C., Leroux M.R., Scambler P.J.,
RA Zhan S.H., Jones S.J., Kayserili H., Tuysuz B., Moorani K.N.,
RA Constantinescu A., Krantz I.D., Kaplan B.S., Shah J.V., Hurd T.W.,
RA Doherty D., Katsanis N., Duncan E.L., Otto E.A., Beales P.L.,
RA Mitchison H.M., Saunier S., Hildebrandt F.;
RT "Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino
RT syndromes in humans.";
RL Am. J. Hum. Genet. 93:915-925(2013).
RN [8]
RP INVOLVEMENT IN RP71, VARIANTS RP71 PRO-257; GLN-1567 AND GLU-1605, AND
RP CHARACTERIZATION OF VARIANTS RP71 PRO-257; GLN-1567 AND GLU-1605.
RX PubMed=25168386; DOI=10.1093/hmg/ddu441;
RA Bujakowska K.M., Zhang Q., Siemiatkowska A.M., Liu Q., Place E.,
RA Falk M.J., Consugar M., Lancelot M.E., Antonio A., Lonjou C.,
RA Carpentier W., Mohand-Said S., den Hollander A.I., Cremers F.P.,
RA Leroy B.P., Gai X., Sahel J.A., van den Born L.I., Collin R.W.,
RA Zeitz C., Audo I., Pierce E.A.;
RT "Mutations in IFT172 cause isolated retinal degeneration and Bardet-
RT Biedl syndrome.";
RL Hum. Mol. Genet. 24:230-242(2015).
CC -!- FUNCTION: Required for the maintenance and formation of cilia.
CC Plays an indirect role in hedgehog (Hh) signaling, cilia being
CC required for all activity of the hedgehog pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IFT88. Interacts with RABL2/RABL2A; binds
CC preferentially to GDP-bound RABL2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:24140113}. Note=Localized to the axoneme and
CC around the base of the cilium.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UG01-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UG01-2; Sequence=VSP_032848, VSP_032849;
CC Note=No experimental confirmation available.;
CC Name=3;
CC IsoId=Q9UG01-3; Sequence=VSP_054428, VSP_054429;
CC Note=No experimental confirmation available.;
CC -!- DISEASE: Short-rib thoracic dysplasia 10 with or without
CC polydactyly (SRTD10) [MIM:615630]: A form of short-rib thoracic
CC dysplasia, a group of autosomal recessive ciliopathies that are
CC characterized by a constricted thoracic cage, short ribs,
CC shortened tubular bones, and a 'trident' appearance of the
CC acetabular roof. Polydactyly is variably present. Non-skeletal
CC involvement can include cleft lip/palate as well as anomalies of
CC major organs such as the brain, eye, heart, kidneys, liver,
CC pancreas, intestines, and genitalia. Some forms of the disease are
CC lethal in the neonatal period due to respiratory insufficiency
CC secondary to a severely restricted thoracic cage, whereas others
CC are compatible with life. Disease spectrum encompasses Ellis-van
CC Creveld syndrome, asphyxiating thoracic dystrophy (Jeune
CC syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly
CC syndrome. {ECO:0000269|PubMed:24140113}. Note=The disease is
CC caused by mutations affecting the gene represented in this entry.
CC -!- DISEASE: Retinitis pigmentosa 71 (RP71) [MIM:616394]: A retinal
CC dystrophy belonging to the group of pigmentary retinopathies.
CC Retinitis pigmentosa is characterized by retinal pigment deposits
CC visible on fundus examination and primary loss of rod
CC photoreceptor cells followed by secondary loss of cone
CC photoreceptors. Patients typically have night vision blindness and
CC loss of midperipheral visual field. As their condition progresses,
CC they lose their far peripheral visual field and eventually central
CC vision as well. {ECO:0000269|PubMed:25168386}. Note=The disease is
CC caused by mutations affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC -----------------------------------------------------------------------
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DR EMBL; AC074117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471053; EAX00573.1; -; Genomic_DNA.
DR EMBL; BC008024; AAH08024.1; -; mRNA.
DR EMBL; BC047294; AAH47294.1; -; mRNA.
DR EMBL; BC137126; AAI37127.1; -; mRNA.
DR EMBL; BC142675; AAI42676.1; -; mRNA.
DR EMBL; BC142729; AAI42730.1; -; mRNA.
DR EMBL; AL110218; CAB53678.1; -; mRNA.
DR EMBL; AL117421; CAB55914.2; -; mRNA.
DR EMBL; AB033005; BAA86493.1; -; mRNA.
DR CCDS; CCDS1755.1; -. [Q9UG01-1]
DR PIR; T14758; T14758.
DR PIR; T17224; T17224.
DR RefSeq; NP_056477.1; NM_015662.2. [Q9UG01-1]
DR UniGene; Hs.127401; -.
DR ProteinModelPortal; Q9UG01; -.
DR BioGrid; 117589; 13.
DR IntAct; Q9UG01; 24.
DR STRING; 9606.ENSP00000260570; -.
DR iPTMnet; Q9UG01; -.
DR PhosphoSitePlus; Q9UG01; -.
DR BioMuta; IFT172; -.
DR DMDM; 182662418; -.
DR EPD; Q9UG01; -.
DR PaxDb; Q9UG01; -.
DR PeptideAtlas; Q9UG01; -.
DR PRIDE; Q9UG01; -.
DR Ensembl; ENST00000260570; ENSP00000260570; ENSG00000138002. [Q9UG01-1]
DR Ensembl; ENST00000359466; ENSP00000352443; ENSG00000138002. [Q9UG01-3]
DR GeneID; 26160; -.
DR KEGG; hsa:26160; -.
DR UCSC; uc002rku.4; human. [Q9UG01-1]
DR CTD; 26160; -.
DR DisGeNET; 26160; -.
DR GeneCards; IFT172; -.
DR H-InvDB; HIX0001924; -.
DR H-InvDB; HIX0119024; -.
DR HGNC; HGNC:30391; IFT172.
DR HPA; HPA044893; -.
DR MalaCards; IFT172; -.
DR MIM; 607386; gene.
DR MIM; 615630; phenotype.
DR MIM; 616394; phenotype.
DR neXtProt; NX_Q9UG01; -.
DR OpenTargets; ENSG00000138002; -.
DR Orphanet; 474; Jeune syndrome.
DR Orphanet; 140969; Saldino-Mainzer syndrome.
DR PharmGKB; PA142671666; -.
DR eggNOG; KOG3616; Eukaryota.
DR eggNOG; ENOG410XR2C; LUCA.
DR GeneTree; ENSGT00440000033648; -.
DR HOGENOM; HOG000286003; -.
DR HOVERGEN; HBG098449; -.
DR InParanoid; Q9UG01; -.
DR KO; K19676; -.
DR OMA; EDIHLKN; -.
DR OrthoDB; EOG091G02TF; -.
DR PhylomeDB; Q9UG01; -.
DR TreeFam; TF312901; -.
DR Reactome; R-HSA-5610787; Hedgehog 'off' state.
DR Reactome; R-HSA-5620924; Intraflagellar transport.
DR SIGNOR; Q9UG01; -.
DR ChiTaRS; IFT172; human.
DR GenomeRNAi; 26160; -.
DR PRO; PR:Q9UG01; -.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000138002; -.
DR CleanEx; HS_IFT172; -.
DR ExpressionAtlas; Q9UG01; baseline and differential.
DR Genevisible; Q9UG01; HS.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0097542; C:ciliary tip; TAS:Reactome.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:1903561; C:extracellular vesicle; IDA:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR GO; GO:0097598; C:sperm cytoplasmic droplet; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IDA:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0008544; P:epidermis development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0061525; P:hindgut development; IEA:Ensembl.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome.
DR GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0060021; P:palate development; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR Gene3D; 1.25.40.10; -; 5.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Ciliopathy;
KW Cilium; Complete proteome; Developmental protein; Disease mutation;
KW Isopeptide bond; Methylation; Polymorphism; Reference proteome;
KW Repeat; Retinitis pigmentosa; TPR repeat; Ubl conjugation; WD repeat.
FT CHAIN 1 1749 Intraflagellar transport protein 172
FT homolog.
FT /FTId=PRO_0000328941.
FT REPEAT 14 53 WD 1.
FT REPEAT 64 103 WD 2.
FT REPEAT 110 148 WD 3.
FT REPEAT 150 191 WD 4.
FT REPEAT 195 233 WD 5.
FT REPEAT 238 278 WD 6.
FT REPEAT 284 323 WD 7.
FT REPEAT 483 520 WD 8.
FT REPEAT 521 559 WD 9.
FT REPEAT 593 624 TPR 1.
FT REPEAT 692 725 TPR 2.
FT REPEAT 809 842 TPR 3.
FT REPEAT 854 887 TPR 4.
FT REPEAT 912 945 TPR 5.
FT REPEAT 947 970 TPR 6.
FT REPEAT 971 1004 TPR 7.
FT REPEAT 1042 1075 TPR 8.
FT REPEAT 1142 1175 TPR 9.
FT REPEAT 1276 1309 TPR 10.
FT REPEAT 1345 1378 TPR 11.
FT REPEAT 1411 1445 TPR 12.
FT REPEAT 1447 1477 TPR 13.
FT REPEAT 1574 1607 TPR 14.
FT MOD_RES 1 1 N-acetylmethionine.
FT {ECO:0000269|PubMed:20388717}.
FT MOD_RES 672 672 Omega-N-methylarginine.
FT {ECO:0000250|UniProtKB:Q6VH22}.
FT CROSSLNK 4 4 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO1).
FT VAR_SEQ 509 532 LHLYDIESCSKTMILNFCSYMQWV -> VRRATKALGIGWP
FT TEGVRQAATRD (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_054428.
FT VAR_SEQ 533 1749 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_054429.
FT VAR_SEQ 1514 1525 CENLVKSSEANS -> AVLSPSSSVKTW (in isoform
FT 2). {ECO:0000303|PubMed:17974005}.
FT /FTId=VSP_032848.
FT VAR_SEQ 1526 1749 Missing (in isoform 2).
FT {ECO:0000303|PubMed:17974005}.
FT /FTId=VSP_032849.
FT VARIANT 257 257 L -> P (in RP71; represents a null
FT allele; dbSNP:rs786205857).
FT {ECO:0000269|PubMed:25168386}.
FT /FTId=VAR_073800.
FT VARIANT 296 296 R -> W (in SRTD10; dbSNP:rs145541911).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070956.
FT VARIANT 411 411 I -> N (in SRTD10; dbSNP:rs587777085).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070957.
FT VARIANT 464 465 Missing (in SRTD10).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070958.
FT VARIANT 953 953 R -> H (in dbSNP:rs704793).
FT /FTId=VAR_042581.
FT VARIANT 1536 1536 L -> P (in SRTD10; dbSNP:rs587777080).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070959.
FT VARIANT 1544 1544 R -> C (in SRTD10; dbSNP:rs587777079).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070960.
FT VARIANT 1567 1567 H -> Q (in RP71; hypomorphic mutation;
FT dbSNP:rs786205855).
FT {ECO:0000269|PubMed:25168386}.
FT /FTId=VAR_073801.
FT VARIANT 1605 1605 D -> E (in RP71; hypomorphic mutation;
FT dbSNP:rs786205856).
FT {ECO:0000269|PubMed:25168386}.
FT /FTId=VAR_073802.
FT VARIANT 1727 1727 C -> R (in SRTD10; dbSNP:rs149614625).
FT {ECO:0000269|PubMed:24140113}.
FT /FTId=VAR_070961.
FT CONFLICT 1475 1475 P -> L (in Ref. 4; CAB55914).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 15 44 ipfam:WD40 [T]
FT MYHIT 279 314 ismart:WD40 [T]
FT MYHIT 225 267 ismart:WD40 [T]
FT MYHIT 102 139 ismart:WD40 [T]
FT MYHIT 55 94 ismart:WD40 [T]
FT MYHIT 186 223 ismart:WD40 [T]
FT MYHIT 141 180 ismart:WD40 [T]
FT MYHIT 2 44 ismart:WD40 [T]
SQ SEQUENCE 1749 AA; 197576 MW; 78AA83802D79E3CE CRC64;
MHLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
PAEYIIVFGL AEGKVRLANT KTNKSSTIYG TESYVVSLTT NCSGKGILSG HADGTIVRYF
FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRKIV AYGKEGHMLQ TFDYSRDPQE
REFTTAVSSP GGQSVVLGSY DRLRVFNWIP RRSIWEEAKP KEITNLYTIT ALAWKRDGSR
LCVGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK SHYGYEVEEV
KILGKERYLV AHTSETLLLG DLNTNRLSEI AWQGSGGNEK YFFENENVCM IFNAGELTLV
EYGNNDTLGS VRTEFMNPHL ISVRINERCQ RGTEDNKKLA YLIDIKTIAI VDLIGGYNIG
TVSHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYMQ WVPGSDVLVA
QNRNSLCVWY NIEAPERVTM FTIRGDVIGL ERGGGKTEVM VMEGVTTVAY TLDEGLIEFG
TAIDDGNYIR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHIAERCFSA LGQVAKARFL
HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMGMYQELHR
WDECIAVAEA KGHPALEKLR RSYYQWLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
KAARLVLTRE ELLANTELVE HITAALIKGE LYERAGDLFE KIHNPQKALE CYRKGNAFMK
AVELARLAFP VEVVKLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
YILDLQDRNT ASKYYPLVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVQEP DLAITMYKKH KLYDDMIRLV
GKHHPDLLSD THLHLGKELE AEGRLQEAEY HYLEAQEWKA TVNMYRASGL WEEAYRVART
QGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEAAVDHA ADNCSFEFAF ELSRLALKHK
TPEVHLKYAM FLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPSQLEAL
QEEYEREATK KGARGVEGFV EQARHWEQAG EYSRAVDCYL KVRDSGNSGL AEKCWMKAAE
LSIKFLPPQR NMEVVLAVGP QLIGIGKHSA AAELYLNLDL VKEAIDAFIE GEEWNKAKRV
AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVIAALDL YVEQGQWDKC IETATKQNYK
ILHKYVALYA THLIREGSSA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNCAEAY
HSWADLRDVL FNLCENLVKS SEANSPAHEE FKTMLLIAHY YATRSAAQSV KQLETVAARL
SVSLLRHTQL LPVDKAFYEA GIAAKAVGWD NMAFIFLNRF LDLTDAIEEG TLDGLDHSDF
QDTDIPFEVP LPAKQHVPEA EREEVRDWVL TVSMDQRLEQ VLPRDERGAY EASLVAASTG
VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
LPSTSFSFQ
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