ID HVM42_MOUSE Reviewed; 117 AA.
AC P01812;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 10-MAY-2017, entry version 77.
DE RecName: Full=Ig heavy chain V region MOPC 173;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP PROTEIN SEQUENCE OF 1-104.
RX PubMed=5062012; DOI=10.1111/j.1432-1033.1972.tb19705.x;
RA Bourgois A., Fougereau M., de Preval C.;
RT "Sequence of amino acids of the NH 2 -terminal region of a mouse-
RT clonal immunoglobulin heavy chain.";
RL Eur. J. Biochem. 24:446-455(1972).
RN [2]
RP PROTEIN SEQUENCE OF 105-117.
RX PubMed=812695; DOI=10.1111/j.1432-1033.1975.tb02478.x;
RA Rocca-Serra J., Milili M., Fougereau M.;
RT "Determination of the primary structure of a mouse IgG2a
RT immunoglobulin. Amino-acid sequence of the H4 cyanogen-bromide
RT fragment.";
RL Eur. J. Biochem. 59:511-523(1975).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 96-117.
RX PubMed=6787590; DOI=10.1073/pnas.78.1.509;
RA Gough N.M., Bernard O.;
RT "Sequences of the joining region genes for immunoglobulin heavy chains
RT and their role in generation of antibody diversity.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:509-513(1981).
RN [4]
RP DISULFIDE BOND.
RX PubMed=11947590; DOI=10.1016/0014-5793(70)80283-6;
RA Bourgois A., Fougereau M.;
RT "Partial amino acid sequence of the variable region of a mouse
RT gammaG2a immunoglobulin heavy chain. Evidence for the existence of a
RT third sub-group of variability for the heavy chain pool.";
RL FEBS Lett. 8:265-268(1970).
CC -!- MISCELLANEOUS: This gamma-2a chain was isolated from a myeloma
CC protein.
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DR PIR; A91190; G2MS73.
DR ProteinModelPortal; P01812; -.
DR SMR; P01812; -.
DR MaxQB; P01812; -.
DR PRIDE; P01812; -.
DR HOVERGEN; HBG018013; -.
DR Proteomes; UP000000589; Unplaced.
DR GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Direct protein sequencing; Disulfide bond;
KW Immunoglobulin domain; Immunoglobulin V region; Reference proteome.
FT CHAIN 1 >117 Ig heavy chain V region MOPC 173.
FT /FTId=PRO_0000059895.
FT DOMAIN 1 116 Ig-like.
FT DISULFID 22 96 {ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:11947590}.
FT CONFLICT 105 105 N -> D (in Ref. 2; AA sequence).
FT {ECO:0000305}.
FT NON_TER 117 117
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 7 116 ismart:IG [T]
FT MYHIT 17 98 ismart:IGv [T]
FT MYHIT 1 116 iprf:IG_LIKE [T]
FT MYHIT 11 115 ipfam:V-set [T]
SQ SEQUENCE 117 AA; 13051 MW; 156DCCC259380F19 CRC64;
EVKLLESGGP LVQLGGSLKL SCAASGFDFS RYWMSWVRQA PGKGLEWIGE IDPNSSTINY
TPSLKDKFII SRNDAKNTLY LQMSKVRSED TALYYCARSP YYAMNYWGQG TSVTVSS
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