ID H0Y4R5_HUMAN Unreviewed; 552 AA.
AC H0Y4R5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 10-MAY-2017, entry version 33.
DE SubName: Full=Transmembrane protein 201 {ECO:0000313|Ensembl:ENSP00000393626};
DE Flags: Fragment;
GN Name=TMEM201 {ECO:0000313|Ensembl:ENSP00000393626};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000393626, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000393626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3] {ECO:0000213|PubMed:18691976}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [4] {ECO:0000213|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5] {ECO:0000213|PubMed:20068231}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:ra3-RA3(2010).
RN [6] {ECO:0000313|Ensembl:ENSP00000393626}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2012) to UniProtKB.
RN [7] {ECO:0000213|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSP00000393626}.
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DR EMBL; AL954705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; H0Y4R5; -.
DR MaxQB; H0Y4R5; -.
DR PeptideAtlas; H0Y4R5; -.
DR PRIDE; H0Y4R5; -.
DR Ensembl; ENST00000416541; ENSP00000393626; ENSG00000188807.
DR UCSC; uc057cau.1; human.
DR HGNC; HGNC:33719; TMEM201.
DR OpenTargets; ENSG00000188807; -.
DR GeneTree; ENSGT00390000002713; -.
DR ChiTaRS; TMEM201; human.
DR Proteomes; UP000005640; Chromosome 1.
DR ExpressionAtlas; H0Y4R5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018861; DUF2448.
DR InterPro; IPR018617; Ima1_N.
DR Pfam; PF10476; DUF2448; 1.
DR Pfam; PF09779; Ima1_N; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0000213|EPD:H0Y4R5,
KW ECO:0000213|MaxQB:H0Y4R5, ECO:0000213|PeptideAtlas:H0Y4R5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 125 146 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 208 226 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 233 250 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 265 284 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 530 551 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 15 81 Ima1_N. {ECO:0000259|Pfam:PF09779}.
FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000393626}.
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CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 15 81 ipfam:Ima1_N [T]
FT MYHIT 101 298 ipfam:DUF2448 [T]
SQ SEQUENCE 552 AA; 59841 MW; C86B32FBA6EAB71E CRC64;
XEHLNHVVSS APSLRDPSQP QQWVSSQVLL CKRCNHHQTT KIKQLAAFAP REEGRYDEEV
EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR QLRALLLSHQ FKRREADQTH AQNFSSAVKS
PVQVILLRAL AFLACAFLLT TALYGASGHF APGTTVPLAL PPGGNGSATP DNGTTPGAEG
WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV VALGLLTCLL AMLLAGRIRL RRIDAFCTCL
WALLLGLHLA EQHLQAASPS WLDTLKFSTT SLCCLVGFTA AVATRKATGP RRFRPRRFFP
GDSAGLFPTS PSLAIPHPSV GGSPASLFIP SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS
RALSLGTIPS LTRADYFSLL SGSCPSSPLP SPAPSVAGSV ASSSGSLRHR RPLISPARLN
LKGQKLLLFP SPPGEAPTTP SSSDEHSPHN GSLFTMEPPH VPRKPPLQDV KHALDLRSKL
ERGSACSNRS IKKEDDSSQS STCVVDTTTR GCSEEAATWR GRFGPSLVRG LLAVSLAANA
LFTSVFLYQS LR
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