Legends: 1, N-linked (GlcNAc...) asparagine. {ECO:0000255}; 2, TOPO_DOM Extracellular. {ECO:0000255}; 3, TRANSMEM Helical; Name=1. {ECO:0000255}; 4, TOPO_DOM Cytoplasmic. {ECO:0000255}; 5, TRANSMEM Helical; Name=2. {ECO:0000255}; 6, TRANSMEM Helical; Name=3. {ECO:0000255}; 7, TRANSMEM Helical; Name=4. {ECO:0000255}; 8, TRANSMEM Helical; Name=5. {ECO:0000255}; 9, TRANSMEM Helical; Name=6. {ECO:0000255}; 10, TRANSMEM Helical; Name=7. {ECO:0000255}.
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ID GP173_DANRE Reviewed; 387 AA.
AC Q9I918;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 10-MAY-2017, entry version 105.
DE RecName: Full=Probable G-protein coupled receptor 173;
DE AltName: Full=Super conserved receptor expressed in brain 3;
GN Name=gpr173; Synonyms=sreb3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 272:576-582(2000).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB040806; BAA96652.1; -; Genomic_DNA.
DR RefSeq; NP_571573.1; NM_131498.1.
DR RefSeq; XP_005167115.1; XM_005167058.3.
DR UniGene; Dr.85372; -.
DR ProteinModelPortal; Q9I918; -.
DR STRING; 7955.ENSDARP00000063004; -.
DR PaxDb; Q9I918; -.
DR Ensembl; ENSDART00000063005; ENSDARP00000063004; ENSDARG00000042922.
DR GeneID; 57926; -.
DR KEGG; dre:57926; -.
DR CTD; 54328; -.
DR ZFIN; ZDB-GENE-000710-1; gpr173.
DR eggNOG; KOG3656; Eukaryota.
DR eggNOG; ENOG410XRW9; LUCA.
DR GeneTree; ENSGT00870000136395; -.
DR HOGENOM; HOG000231471; -.
DR HOVERGEN; HBG051805; -.
DR InParanoid; Q9I918; -.
DR KO; K04300; -.
DR OMA; KRMTFWT; -.
DR OrthoDB; EOG091G0AOZ; -.
DR PhylomeDB; Q9I918; -.
DR TreeFam; TF331163; -.
DR PRO; PR:Q9I918; -.
DR Proteomes; UP000000437; Chromosome 8.
DR Bgee; ENSDARG00000042922; -.
DR ExpressionAtlas; Q9I918; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 387 Probable G-protein coupled receptor 173.
FT /FTId=PRO_0000069653.
FT TOPO_DOM 1 40 Extracellular. {ECO:0000255}.
FT TRANSMEM 41 61 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 62 87 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 88 108 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 109 111 Extracellular. {ECO:0000255}.
FT TRANSMEM 112 132 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 133 153 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 154 174 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 175 202 Extracellular. {ECO:0000255}.
FT TRANSMEM 203 223 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 224 301 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 302 322 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 323 335 Extracellular. {ECO:0000255}.
FT TRANSMEM 336 356 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 357 387 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CARBOHYD 198 198 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT DISULFID 110 188 {ECO:0000255|PROSITE-ProRule:PRU00521}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 53 354 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 53 353 ipfam:7tm_1 [T]
SQ SEQUENCE 387 AA; 43410 MW; 5E094EFD44120871 CRC64;
MANGNASSDG PGNPLAAVVS TTGGVMGGAP SSAVSTYVKL VLLGLIICIS LVGNLVVSLL
VLRDRALHKA PYYFLLDLCL ADTIRSAVCF PFVLVSIKNG SAWTYSVLSC KVVAFMAVLF
CFHAAFMLFC ISVTRYMAIA HHRFYSKRMT FWTCVAVVCM VWTLSVAMAF PPVFDVGTYK
FIREEDQCIF EHRYFKANDT LGFMLMLAVL ILATHVVYMK LLLFEYKHRK MKPVQMVPAI
SQNWTFHGPG ATGQAAANWI AGFGRGPMPP TLLGIRQNLH NQNRRLLGME EFKAEKQLGR
MFYVITLFFL VLWSPYIVAC YWRVFVKACT IPHRYLSTTV WMSFAQAGVN PIICFFLNKD
LKKGLLAHLP PCCRTPPQLP REPYCVM
//
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