ID GP171_HUMAN Reviewed; 319 AA.
AC O14626; D3DNJ4; Q8IV06;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 10-MAY-2017, entry version 134.
DE RecName: Full=Probable G-protein coupled receptor 171;
DE AltName: Full=G-protein coupled receptor H963;
GN Name=GPR171; Synonyms=H963;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood monocyte;
RX PubMed=9370294; DOI=10.1016/S0378-1119(97)00330-2;
RA Jacobs K.A., Collins-Racie L.A., Colbert M., Duckett M.,
RA Golden-Fleet M., Kelleher K., Kriz R., LaVallie E.R., Merberg D.,
RA Spaulding V., Stover J., Williamson M.J., McCoy J.M.;
RT "A genetic selection for isolating cDNAs encoding secreted proteins.";
RL Gene 198:289-296(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11524702; DOI=10.1086/323610;
RA Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S.,
RA Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E.,
RA de la Chapelle A., Sankila E.-M.;
RT "Mutations in a novel gene with transmembrane domains underlie Usher
RT syndrome type 3.";
RL Am. J. Hum. Genet. 69:673-684(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-283.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF002986; AAC51846.1; -; mRNA.
DR EMBL; AF411849; AAL47763.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78811.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78812.1; -; Genomic_DNA.
DR EMBL; BC036815; AAH36815.1; -; mRNA.
DR CCDS; CCDS3155.1; -.
DR RefSeq; NP_037440.3; NM_013308.3.
DR RefSeq; XP_005247459.1; XM_005247402.3.
DR RefSeq; XP_005247460.1; XM_005247403.3.
DR RefSeq; XP_016861763.1; XM_017006274.1.
DR UniGene; Hs.549152; -.
DR ProteinModelPortal; O14626; -.
DR STRING; 9606.ENSP00000308479; -.
DR PhosphoSitePlus; O14626; -.
DR BioMuta; GPR171; -.
DR PaxDb; O14626; -.
DR PeptideAtlas; O14626; -.
DR PRIDE; O14626; -.
DR DNASU; 29909; -.
DR Ensembl; ENST00000309180; ENSP00000308479; ENSG00000174946.
DR Ensembl; ENST00000617554; ENSP00000482588; ENSG00000174946.
DR GeneID; 29909; -.
DR KEGG; hsa:29909; -.
DR UCSC; uc003eyq.5; human.
DR CTD; 29909; -.
DR DisGeNET; 29909; -.
DR GeneCards; GPR171; -.
DR HGNC; HGNC:30057; GPR171.
DR HPA; HPA062429; -.
DR neXtProt; NX_O14626; -.
DR OpenTargets; ENSG00000174946; -.
DR PharmGKB; PA134948560; -.
DR eggNOG; ENOG410IICW; Eukaryota.
DR eggNOG; ENOG410YCG6; LUCA.
DR GeneTree; ENSGT00640000091213; -.
DR HOGENOM; HOG000273884; -.
DR HOVERGEN; HBG095159; -.
DR InParanoid; O14626; -.
DR KO; K08441; -.
DR OMA; IMVPNMV; -.
DR OrthoDB; EOG091G0B1Z; -.
DR PhylomeDB; O14626; -.
DR TreeFam; TF330969; -.
DR GeneWiki; GPR171; -.
DR GenomeRNAi; 29909; -.
DR PRO; PR:O14626; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000174946; -.
DR CleanEx; HS_GPR171; -.
DR ExpressionAtlas; O14626; baseline and differential.
DR Genevisible; O14626; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G-protein coupled receptor activity; NAS:UniProtKB.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 319 Probable G-protein coupled receptor 171.
FT /FTId=PRO_0000069649.
FT TOPO_DOM 1 21 Extracellular. {ECO:0000255}.
FT TRANSMEM 22 42 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 43 48 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 49 69 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 70 89 Extracellular. {ECO:0000255}.
FT TRANSMEM 90 110 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 111 132 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 133 153 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 154 181 Extracellular. {ECO:0000255}.
FT TRANSMEM 182 202 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 203 224 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 225 245 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 246 268 Extracellular. {ECO:0000255}.
FT TRANSMEM 269 289 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 290 319 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 3 3 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT VARIANT 283 283 I -> V (in dbSNP:rs3732756).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_049408.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 100 116 ipat:G_PROTEIN_RECEP_F1_1 [T]
FT MYHIT 35 285 ipfam:7tm_1 [T]
FT MYHIT 31 285 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 319 AA; 36754 MW; 79B9821C10841114 CRC64;
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD
FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC
KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT
NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH
IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
ASPKETKAQK EKLRCENNA
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