MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Probable G-protein coupled receptor 139; AltName: Full=G(q)-coupled orphan receptor GPRg1; |
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| MyHits synonyms | GP139_RAT , P0C0W8 , 270D568005EB6031 |
 Legends: 1, N-linked (GlcNAc...) asparagine. {ECO:0000255}; 2, TOPO_DOM Extracellular. {ECO:0000255}; 3, TRANSMEM Helical; Name=1. {ECO:0000255}; 4, TOPO_DOM Cytoplasmic. {ECO:0000255}; 5, TRANSMEM Helical; Name=2. {ECO:0000255}; 6, TRANSMEM Helical; Name=3. {ECO:0000255}; 7, TRANSMEM Helical; Name=4. {ECO:0000255}; 8, TRANSMEM Helical; Name=5. {ECO:0000255}; 9, TRANSMEM Helical; Name=6. {ECO:0000255}; 10, TRANSMEM Helical; Name=7. {ECO:0000255}.
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ID GP139_RAT Reviewed; 345 AA.
AC P0C0W8;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 10-MAY-2017, entry version 70.
DE RecName: Full=Probable G-protein coupled receptor 139;
DE AltName: Full=G(q)-coupled orphan receptor GPRg1;
GN Name=Gpr139; Synonyms=Gprg1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT "Molecular cloning and characterization of a novel Gq-coupled orphan
RT receptor GPRg1 exclusively expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 331:363-369(2005).
CC -!- FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated
CC pathway.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB196531; BAD97442.1; -; mRNA.
DR RefSeq; NP_001019412.1; NM_001024241.1.
DR UniGene; Rn.215835; -.
DR ProteinModelPortal; P0C0W8; -.
DR STRING; 10116.ENSRNOP00000037722; -.
DR PhosphoSitePlus; P0C0W8; -.
DR PaxDb; P0C0W8; -.
DR PRIDE; P0C0W8; -.
DR Ensembl; ENSRNOT00000032796; ENSRNOP00000037722; ENSRNOG00000023863.
DR GeneID; 293545; -.
DR KEGG; rno:293545; -.
DR UCSC; RGD:1311729; rat.
DR CTD; 124274; -.
DR RGD; 1311729; Gpr139.
DR eggNOG; KOG3656; Eukaryota.
DR eggNOG; ENOG410XRW9; LUCA.
DR GeneTree; ENSGT00390000006613; -.
DR HOGENOM; HOG000231257; -.
DR HOVERGEN; HBG081564; -.
DR InParanoid; P0C0W8; -.
DR KO; K08428; -.
DR OMA; NLWTEDY; -.
DR OrthoDB; EOG091G0HIF; -.
DR PhylomeDB; P0C0W8; -.
DR TreeFam; TF334275; -.
DR PRO; PR:P0C0W8; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000023863; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008188; F:neuropeptide receptor activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 345 Probable G-protein coupled receptor 139.
FT /FTId=PRO_0000069617.
FT TOPO_DOM 1 21 Extracellular. {ECO:0000255}.
FT TRANSMEM 22 42 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 43 57 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 58 78 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 79 94 Extracellular. {ECO:0000255}.
FT TRANSMEM 95 115 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 116 140 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 141 161 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 162 173 Extracellular. {ECO:0000255}.
FT TRANSMEM 174 194 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 195 220 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 221 241 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 242 260 Extracellular. {ECO:0000255}.
FT TRANSMEM 261 281 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 282 345 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 11 11 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
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CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 35 277 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 36 277 ipfam:7tm_1 [T]
SQ SEQUENCE 345 AA; 39742 MW; 270D568005EB6031 CRC64;
MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR QKSSYNYLLA
LAAADILVLF FIVFVDFLLE DFILTMQMPP IPDKIIEVLE FSSIHTSIWI TVPLTVDRYI
AVCHPLKYHT VSYPARTRKV ILSVYITCFL TSIPYYWWPN IWTEDYISTS MHHVLVWIHC
FTVYLVPCSI FFILNSIIVY KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI
LYHLYGAPIQ NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
//
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