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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionRecName: Full=Probable G-protein coupled receptor 139; AltName: Full=G(q)-coupled orphan receptor GPRg1; AltName: Full=G-protein-coupled receptor PGR3;
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MyHits synonymsGP139_MOUSE , Q80UC8 , Q059X1 , 764D568B29EB6036
match map segment
ipfam:7tm_1 iprf:G_PROTEIN_RECEP_F1_2  
Legends: 1, N-linked (GlcNAc...) asparagine. {ECO:0000255}; 2, TOPO_DOM Extracellular. {ECO:0000255}; 3, TRANSMEM Helical; Name=1. {ECO:0000255}; 4, TOPO_DOM Cytoplasmic. {ECO:0000255}; 5, TRANSMEM Helical; Name=2. {ECO:0000255}; 6, TRANSMEM Helical; Name=3. {ECO:0000255}; 7, TRANSMEM Helical; Name=4. {ECO:0000255}; 8, TRANSMEM Helical; Name=5. {ECO:0000255}; 9, TRANSMEM Helical; Name=6. {ECO:0000255}; 10, TRANSMEM Helical; Name=7. {ECO:0000255}. 
ID   GP139_MOUSE             Reviewed;         345 AA.
AC   Q80UC8; Q059X1;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   10-MAY-2017, entry version 89.
DE   RecName: Full=Probable G-protein coupled receptor 139;
DE   AltName: Full=G(q)-coupled orphan receptor GPRg1;
DE   AltName: Full=G-protein-coupled receptor PGR3;
GN   Name=Gpr139; Synonyms=Gm495, Gprg1, Pgr3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15845401; DOI=10.1016/j.bbrc.2005.03.174;
RA   Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J.,
RA   Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.;
RT   "Molecular cloning and characterization of a novel Gq-coupled orphan
RT   receptor GPRg1 exclusively expressed in the central nervous system.";
RL   Biochem. Biophys. Res. Commun. 331:363-369(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 218-271.
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC   -!- FUNCTION: Orphan receptor. Seems to act through a G(q/11)-mediated
CC       pathway.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed almost exclusively in the brain.
CC       Abundantly expressed in the ventrolateral region of caudate
CC       putamen, the habenular nucleus, the zona incerta, and the medial
CC       mammillary nucleus. {ECO:0000269|PubMed:15845401}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AB196532; BAD97443.1; -; mRNA.
DR   EMBL; BC125496; AAI25497.1; -; mRNA.
DR   EMBL; BC125498; AAI25499.1; -; mRNA.
DR   EMBL; AY255548; AAO85060.1; -; mRNA.
DR   CCDS; CCDS21778.1; -.
DR   RefSeq; NP_001019309.1; NM_001024138.1.
DR   UniGene; Mm.300632; -.
DR   ProteinModelPortal; Q80UC8; -.
DR   STRING; 10090.ENSMUSP00000081700; -.
DR   PhosphoSitePlus; Q80UC8; -.
DR   PaxDb; Q80UC8; -.
DR   PRIDE; Q80UC8; -.
DR   Ensembl; ENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197.
DR   GeneID; 209776; -.
DR   KEGG; mmu:209776; -.
DR   UCSC; uc009jky.1; mouse.
DR   CTD; 124274; -.
DR   MGI; MGI:2685341; Gpr139.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   GeneTree; ENSGT00390000006613; -.
DR   HOGENOM; HOG000231257; -.
DR   HOVERGEN; HBG081564; -.
DR   InParanoid; Q80UC8; -.
DR   KO; K08428; -.
DR   OMA; RIAGNIC; -.
DR   OrthoDB; EOG091G0HIF; -.
DR   PhylomeDB; Q80UC8; -.
DR   TreeFam; TF334275; -.
DR   PRO; PR:Q80UC8; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000066197; -.
DR   CleanEx; MM_GPR139; -.
DR   ExpressionAtlas; Q80UC8; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IC:MGI.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IDA:MGI.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IDA:MGI.
DR   GO; GO:0046983; F:protein dimerization activity; IDA:MGI.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.
DR   GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    345       Probable G-protein coupled receptor 139.
FT                                /FTId=PRO_0000069616.
FT   TOPO_DOM      1     21       Extracellular. {ECO:0000255}.
FT   TRANSMEM     22     42       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     43     57       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     58     78       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     79     94       Extracellular. {ECO:0000255}.
FT   TRANSMEM     95    115       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    116    140       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    141    161       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    162    173       Extracellular. {ECO:0000255}.
FT   TRANSMEM    174    194       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    195    220       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    221    241       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    242    260       Extracellular. {ECO:0000255}.
FT   TRANSMEM    261    281       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    282    345       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     11     11       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        36    277       ipfam:7tm_1 [T]
FT   MYHIT        35    277       iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ   SEQUENCE   345 AA;  39758 MW;  764D568B29EB6036 CRC64;
     MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR QKSSYNYLLA
     LAAADILVLF FIVFVDFLLE DFILTMQMPL IPDKIIEVLE FSSIHTSIWI TVPLTVDRYI
     AVCHPLKYHT VSYPARTRKV ILSVYITCFL TSIPYYWWPN IWTEDYISTS MHHVLVWIHC
     FTVYLVPCSI FFILNSIIVY KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI
     LYHLYGAPIQ NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
     QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
//