ID G5EA27_HUMAN Unreviewed; 106 AA.
AC G5EA27;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 10-MAY-2017, entry version 39.
DE SubName: Full=HCG2039995, isoform CRA_a {ECO:0000313|EMBL:EAW74101.1};
DE SubName: Full=Transmembrane protein 223 {ECO:0000313|Ensembl:ENSP00000436670};
GN Name=TMEM223 {ECO:0000313|Ensembl:ENSP00000436670};
GN ORFNames=hCG_2039995 {ECO:0000313|EMBL:EAW74101.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436670, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|EMBL:EAW74101.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2] {ECO:0000313|Ensembl:ENSP00000436670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [3] {ECO:0000313|EMBL:EAW74101.1}
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5] {ECO:0000213|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6] {ECO:0000313|Ensembl:ENSP00000436670}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2011) to UniProtKB.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AP001160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW74101.1; -; Genomic_DNA.
DR STRING; 9606.ENSP00000303987; -.
DR Ensembl; ENST00000525631; ENSP00000436670; ENSG00000168569.
DR UCSC; uc058cne.1; human.
DR HGNC; HGNC:28464; TMEM223.
DR OpenTargets; ENSG00000168569; -.
DR eggNOG; ENOG410IWJD; Eukaryota.
DR eggNOG; ENOG4111M6M; LUCA.
DR GeneTree; ENSGT00390000012589; -.
DR ChiTaRS; TMEM223; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000168569; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026100; Tmem223.
DR PANTHER; PTHR14549; PTHR14549; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43 67 Helical. {ECO:0000256|SAM:Phobius}.
SQ SEQUENCE 106 AA; 11630 MW; 492ED52FBA57AEEB CRC64;
MAAPWRRWPT GLLAVLRPLL TCRPLQGTTL QRDVLLFEHD RGRFFTILGL FCAGQGVFWA
SMAVAAVSRP PVPVQPLDAE VPNRGPFDLR SALWRYGLAV GCGAIA
//
|
