ID G3H6L3_CRIGR Unreviewed; 518 AA.
AC G3H6L3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 10-MAY-2017, entry version 39.
DE SubName: Full=Zinc finger protein {ECO:0000313|EMBL:ERE65418.1};
DE SubName: Full=Zinc finger protein 449 {ECO:0000313|EMBL:EGW03171.1};
GN ORFNames=H671_xg20261 {ECO:0000313|EMBL:ERE65418.1},
GN I79_005978 {ECO:0000313|EMBL:EGW03171.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03171.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA Quake S.R., Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW03171.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA Quake S.R., Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000030759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX PubMed=23929341; DOI=10.1038/nbt.2645;
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
RA Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
RA Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
RA Goesmann A., Helk B., Mott J.E., Puhler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Nat. Biotechnol. 31:694-695(2013).
RN [4] {ECO:0000313|EMBL:ERE65418.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE65418.1};
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
RA Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
RA Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
RA Goesmann A., Helk B., Mott J.E., Puehler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC ProRule:PRU00187, ECO:0000256|SAAS:SAAS00772597}.
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DR EMBL; JH000176; EGW03171.1; -; Genomic_DNA.
DR EMBL; KE684445; ERE65418.1; -; Genomic_DNA.
DR RefSeq; XP_007623794.1; XM_007625604.2.
DR ProteinModelPortal; G3H6L3; -.
DR GeneID; 100764457; -.
DR CTD; 203523; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000030759; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW Metal-binding {ECO:0000256|SAAS:SAAS00772615};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187,
KW ECO:0000256|SAAS:SAAS00772585};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|SAAS:SAAS00772661};
KW Transcription {ECO:0000256|SAAS:SAAS00772592};
KW Transcription regulation {ECO:0000256|SAAS:SAAS00772592};
KW Zinc {ECO:0000256|SAAS:SAAS00772615};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00772615}.
FT DOMAIN 30 112 SCAN box. {ECO:0000259|PROSITE:PS50804}.
FT DOMAIN 323 350 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 351 378 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 379 406 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 407 434 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 435 462 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 463 490 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 491 513 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 465 485 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 493 513 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 435 457 ismart:ZnF_C2H2 [T]
FT MYHIT 325 345 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 435 462 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 26 134 ismart:SCAN [T]
FT MYHIT 379 406 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 491 513 ismart:ZnF_C2H2 [T]
FT MYHIT 27 113 ipfam:SCAN [T]
FT MYHIT 407 429 ismart:ZnF_C2H2 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 463 485 ismart:ZnF_C2H2 [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 407 434 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 323 345 ismart:ZnF_C2H2 [T]
FT MYHIT 409 429 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 323 350 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 437 457 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 491 513 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 381 401 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 353 373 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 30 112 iprf:SCAN_BOX [T]
FT MYHIT 463 490 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 379 401 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 518 AA; 59955 MW; 09DC2F420CB253EA CRC64;
MAVALGCAIQ ASLNQGSVLQ EYDTDCEVFR QRFRQFQYTE AAGPHEAFNK LWELCCQWLK
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPDNRER VVSLIEDLQR ELEIPEPQID
MDDMLLEELA PVGTVPMPPN LHLDAPELQV MEPVQEPPVP EAWIPQPGPQ DLNYSADAEC
QSFLDPGYQL PKLDMNFPLD HREEPWVKEL QDPKEMKQLL DSKIGFEMGI ENEEDSSKEK
KLETMYPFVV TLEGNALHGP ILEKDYVQLE NQWEPSPEDL QTDLTKLVEP QNSSLGETPE
SSNLEEPLNP KPPKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT HSEEETYKCL ECGKSFCHGS
SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCSYCGK SFRQRPSLVI
HLRIHTGEKP YKCSHCSKSF RQRAGLIMHQ VTHFRGLL
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