Entry euk:FP100_MOUSE

ID   FP100_MOUSE             Reviewed;         879 AA.
AC   A2ACJ2; Q0P653; Q810W2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   10-MAY-2017, entry version 74.
DE   RecName: Full=Fanconi anemia core complex-associated protein 100 {ECO:0000250|UniProtKB:Q0VG06};
DE   AltName: Full=Fanconi anemia-associated protein of 100 kDa;
GN   Name=Faap100 {ECO:0000250|UniProtKB:Q0VG06};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-879.
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in Fanconi anemia-associated DNA damage
CC       response network. Regulates FANCD2 monoubiquitination and the
CC       stability of the FA core complex. Induces chromosomal instability
CC       as well as hypersensitivity to DNA cross-linking agents, when
CC       repressed (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and
CC       FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH34203.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH48376.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AK148234; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
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DR   EMBL; AK148234; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL669855; CAM27039.1; -; Genomic_DNA.
DR   EMBL; BC034203; AAH34203.1; ALT_INIT; mRNA.
DR   EMBL; BC048376; AAH48376.1; ALT_INIT; mRNA.
DR   CCDS; CCDS49004.1; -.
DR   RefSeq; NP_082256.2; NM_027980.2.
DR   UniGene; Mm.274890; -.
DR   SMR; A2ACJ2; -.
DR   BioGrid; 215005; 8.
DR   IntAct; A2ACJ2; 8.
DR   STRING; 10090.ENSMUSP00000026448; -.
DR   iPTMnet; A2ACJ2; -.
DR   PhosphoSitePlus; A2ACJ2; -.
DR   EPD; A2ACJ2; -.
DR   MaxQB; A2ACJ2; -.
DR   PaxDb; A2ACJ2; -.
DR   PRIDE; A2ACJ2; -.
DR   DNASU; 71885; -.
DR   Ensembl; ENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384.
DR   GeneID; 71885; -.
DR   KEGG; mmu:71885; -.
DR   UCSC; uc007msm.2; mouse.
DR   CTD; 80233; -.
DR   MGI; MGI:1919135; Faap100.
DR   eggNOG; ENOG410IEYW; Eukaryota.
DR   eggNOG; ENOG410YKI3; LUCA.
DR   GeneTree; ENSGT00390000016682; -.
DR   HOGENOM; HOG000112640; -.
DR   HOVERGEN; HBG107926; -.
DR   InParanoid; A2ACJ2; -.
DR   KO; K10993; -.
DR   OMA; WHLELLA; -.
DR   OrthoDB; EOG091G0D5C; -.
DR   TreeFam; TF330817; -.
DR   Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR   PRO; PR:A2ACJ2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000025384; -.
DR   CleanEx; MM_2310003H01RIK; -.
DR   Genevisible; A2ACJ2; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR029251; Faap100.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF15146; FANCAA; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN         1    879       Fanconi anemia core complex-associated
FT                                protein 100.
FT                                /FTId=PRO_0000289131.
FT   CONFLICT    436    436       S -> P (in Ref. 1; AK148234).
FT                                {ECO:0000305}.
FT   CONFLICT    856    856       S -> G (in Ref. 1; AK148234).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       448    879       ipfam:FANCAA [T]
SQ   SEQUENCE   879 AA;  94281 MW;  83F2DF42485E2F50 CRC64;
     MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE GGLLTAVYQF
     PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA CEDKEEAAPP YPVIHVDPDA
     CVLPDAALCA FTVLDDMLVT LAQGPTQWKM QLFERPCAGE EPLPRGQIGE VELSTCTPPG
     GVPEKPAAPR FLPVLCCVFP PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL
     CGLPDGQLCC VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL
     PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC DRDGHVYHST
     PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC SALALCVTAR APTGSTELLA
     LSSKGRLITC SLDLNSEAPV PAKMAMANAG QKIKELLLDI GDVSERVSFL KKAVDQRNKA
     ITSLNEAMNV SCALLSHPEG DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT
     LCIQVLTSSS ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL
     FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC LRFAGAATHP
     AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP PSTASIRVSA GLLRAALEDS
     HSGFHLCSAT LRWLLAENAA VDVVRAQTLS SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI
     QAVEIQVESS SLANMCRAHH AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR
     EVQALRDQLC TEDELSSCST AQKLLHIYKQ LRNPSLVLL
//