ID F1R0Y0_DANRE Unreviewed; 251 AA.
AC F1R0Y0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 2.
DT 12-APR-2017, entry version 31.
DE SubName: Full=Pim proto-oncogene, serine/threonine kinase,-related 173 {ECO:0000313|Ensembl:ENSDARP00000067271};
DE Flags: Fragment;
GN Name=pimr173 {ECO:0000313|Ensembl:ENSDARP00000067271,
GN ECO:0000313|ZFIN:ZDB-GENE-041210-89};
GN Synonyms=pcloa {ECO:0000313|ZFIN:ZDB-GENE-041210-89},
GN si:dkey-108d22.5 {ECO:0000313|ZFIN:ZDB-GENE-041210-89};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000067271, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000067271}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067271};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000067271, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067271,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000067271}.
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DR EMBL; BX469931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; F1R0Y0; -.
DR Ensembl; ENSDART00000067272; ENSDARP00000067271; ENSDARG00000070015.
DR ZFIN; ZDB-GENE-041210-89; pimr173.
DR GeneTree; ENSGT00760000119045; -.
DR Proteomes; UP000000437; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR017348; PIM1/2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF037993; STPK_Pim-1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR037993-2};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037993-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1 247 Protein kinase.
FT {ECO:0000259|PROSITE:PS50011}.
FT ACT_SITE 124 124 Proton acceptor.
FT {ECO:0000256|PIRSR:PIRSR037993-1}.
FT BINDING 20 20 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 77 77 ATP; via carbonyl oxygen.
FT {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 84 84 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSDARP00000067271}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 2 247 ipfam:Pkinase [T]
FT MYHIT 1 247 iprf:PROTEIN_KINASE_DOM [T]
FT MYHIT 120 132 ipat:PROTEIN_KINASE_ST [T]
FT MYHIT 1 247 ismart:S_TKc [T]
SQ SEQUENCE 251 AA; 28820 MW; 129072A77894CC3F CRC64;
GFGSVYKATR RRDGLKVAVK CTVKSSKMKE ITVPGYDKPL PTEIALTIMA NNGPYVPEII
KLLDWEDNDD HYVIIMERPI PCMDLFCFLN HNNGPLDEKT GRHIMRQAIH AVSVCFNRGV
FHRDIKLENL LVNPDTLEVK LIDFGCGAIA KESGYKVFCG TREYFPPEYE LYGRYHAQPA
TVWSLGIVLF AMMCWALPTV SDHSLIRDYL WTRTDLSKEC CQMICGCLQP DPDERLALQE
MHLHNWFKVM E
//
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