ID F1QW85_DANRE Unreviewed; 344 AA.
AC F1QW85;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 10-MAY-2017, entry version 43.
DE SubName: Full=Zgc:136493 {ECO:0000313|Ensembl:ENSDARP00000040755};
GN ORFNames=zgc:136493 {ECO:0000313|Ensembl:ENSDARP00000040755,
GN ECO:0000313|ZFIN:ZDB-GENE-060512-216};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000040755, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000040755}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040755};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000040755, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040755,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000040755}.
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DR EMBL; CR391941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005158196.1; XM_005158139.2.
DR UniGene; Dr.29877; -.
DR ProteinModelPortal; F1QW85; -.
DR STRING; 7955.ENSDARP00000040755; -.
DR PaxDb; F1QW85; -.
DR Ensembl; ENSDART00000040756; ENSDARP00000040755; ENSDARG00000029259.
DR GeneID; 692276; -.
DR ZFIN; ZDB-GENE-060512-216; zgc:136493.
DR eggNOG; KOG0069; Eukaryota.
DR eggNOG; COG1052; LUCA.
DR GeneTree; ENSGT00510000046913; -.
DR InParanoid; F1QW85; -.
DR OMA; DRELECP; -.
DR OrthoDB; EOG091G0VB7; -.
DR TreeFam; TF324791; -.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000029259; -.
DR ExpressionAtlas; F1QW85; baseline.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Proteomics identification {ECO:0000213|PeptideAtlas:F1QW85};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 65 342 2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
FT DOMAIN 132 311 2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 171 198 ipat:D_2_HYDROXYACID_DH_1 [T]
FT MYHIT 132 311 ipfam:2-Hacid_dh_C [T]
FT MYHIT 65 342 ipfam:2-Hacid_dh [T]
SQ SEQUENCE 344 AA; 38255 MW; 62924F993B3119A6 CRC64;
MTVIRFQGIH RLRSTVTRVV MEKPCILTKT LGAPGSIYKC FEPCIDKHFT IIPYERFVQR
KEDFAAKIQA VFSWGPNINV DRDLLQSLPN LKAVINGGVG VDHLDIPLIN SFGVKVSNTP
HVVDNATADI GMSLMLASAR KIIEGQHFSK FRESDDFPES TMGTDVSGAT LGIIGMGRIG
YKIAKRAQGF DMKILYHNRN RRPENEERAV GATYCASMTE LLQRSDFVMV VVNLSPQTHK
LISAKEFAMM RPNSTFINIS RGLVVDQDAL VDALLKKMIR AAALDVTYPE PLPRDHPLLS
FPNVIVMPHI GTHTLETSQL MVERMVTNAL AILNEGQLPD EVKA
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