Entry euk:F1QP54_DANRE

ID   F1QP54_DANRE            Unreviewed;       380 AA.
AC   F1QP54;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   10-MAY-2017, entry version 48.
DE   SubName: Full=Zgc:63568 {ECO:0000313|Ensembl:ENSDARP00000117359};
GN   ORFNames=zgc:63568 {ECO:0000313|Ensembl:ENSDARP00000117359,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-1165};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000117359, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000117359}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117359};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000117359, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117359,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000117359}.
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DR   EMBL; CT009687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F1QP54; -.
DR   STRING; 7955.ENSDARP00000117359; -.
DR   PaxDb; F1QP54; -.
DR   Ensembl; ENSDART00000135079; ENSDARP00000117359; ENSDARG00000087262.
DR   ZFIN; ZDB-GENE-040426-1165; zgc:63568.
DR   eggNOG; KOG0022; Eukaryota.
DR   eggNOG; COG1062; LUCA.
DR   GeneTree; ENSGT00430000030800; -.
DR   InParanoid; F1QP54; -.
DR   OMA; QYTVVPD; -.
DR   OrthoDB; EOG091G08N3; -.
DR   TreeFam; TF300429; -.
DR   Reactome; R-DRE-2161541; Abacavir metabolism.
DR   Reactome; R-DRE-5365859; RA biosynthesis pathway.
DR   Reactome; R-DRE-71384; Ethanol oxidation.
DR   Proteomes; UP000000437; Chromosome 14.
DR   Bgee; ENSDARG00000087262; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN       22    378       PKS_ER. {ECO:0000259|SMART:SM00829}.
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CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        38    167       ipfam:ADH_N [T]
FT   MYHIT        73     87       ipat:ADH_ZINC [T]
FT   MYHIT        22    378       ismart:PKS_ER [T]
FT   MYHIT       209    335       ipfam:ADH_zinc_N [T]
SQ   SEQUENCE   380 AA;  40672 MW;  9E8AA348107E0394 CRC64;
     MVAMETEGKV IKCKVAVAWE PGKPLSIEKV EVAPPKAHEV RIKIAASGVC HSDWAYLYDI
     AKMKPRPFPL VLGHEGAGVV ESVGPGVTKV SIGDKVIPLF LPQCGQCERC QSPKTNLCTK
     NWEKTQQGVL ADGTSRITCK NQQVHQFIGI STFSEYTVVP EDNVTKIHPD APLDRVCLLG
     CGVSTGYGAA VNTGKVESGS TCAVFGLGAV GLAAVMGCKA AGASRIIAVD INSDKFEIGK
     TFGATEFVNH KDHSKSIQEV LRELTNGGVD YALECVGDVA VMRAAVEACS PAGGVCVIVG
     WIEVEELSLA PLDILLGRTL KGTYFGGWKS VEAVPRLVQD YMSRKILLDE FVTHRLALDQ
     INQAFDLIVS GKSIRTVIEM
//