ID EM506_ARATH Reviewed; 315 AA.
AC Q9SQK3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 12-APR-2017, entry version 117.
DE RecName: Full=Ankyrin repeat domain-containing protein EMB506, chloroplastic;
DE AltName: Full=Protein EMBRYO DEFECTIVE 506;
DE Flags: Precursor;
GN Name=EMB506; OrderedLocusNames=At5g40160; ORFNames=MSN9.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10074714; DOI=10.1046/j.1365-313X.1999.00361.x;
RA Albert S., Despres B., Guilleminot J., Bechtold N., Pelletier G.,
RA Delseny M., Devic M.;
RT "The EMB 506 gene encodes a novel ankyrin repeat containing protein
RT that is essential for the normal development of Arabidopsis embryos.";
RL Plant J. 17:169-179(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one
RT physically assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Portal (Araport);
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=11489192; DOI=10.1046/j.1365-313x.2001.01078.x;
RA Despres B., Delseny M., Devic M.;
RT "Partial complementation of embryo defective mutations: a general
RT strategy to elucidate gene function.";
RL Plant J. 27:149-159(2001).
RN [6]
RP FUNCTION.
RX PubMed=16786300; DOI=10.1007/s11103-006-6268-6;
RA Latvala-Kilby S.M.H., Kilby N.J.;
RT "Uncovering the post-embryonic role of embryo essential genes in
RT Arabidopsis using the controlled induction of visibly marked genetic
RT mosaics: EMB506, an illustration.";
RL Plant Mol. Biol. 61:179-194(2006).
RN [7]
RP INTERACTION WITH AKR, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=17092312; DOI=10.1111/j.1365-313X.2006.02922.x;
RA Garcion C., Guilleminot J., Kroj T., Parcy F., Giraudat J., Devic M.;
RT "AKRP and EMB506 are two ankyrin repeat proteins essential for plastid
RT differentiation and plant development in Arabidopsis.";
RL Plant J. 48:895-906(2006).
CC -!- FUNCTION: Involved in the initial differentiation of the
CC proplastid during the embryo development. Also required for
CC correct cotyledon, true leaf and cauline leaf margin development.
CC {ECO:0000269|PubMed:11489192, ECO:0000269|PubMed:16786300}.
CC -!- SUBUNIT: Interacts with AKR. No homodimerization observed.
CC {ECO:0000269|PubMed:17092312}.
CC -!- INTERACTION:
CC Q05753:AKRP; NbExp=3; IntAct=EBI-2114010, EBI-2114020;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:11489192, ECO:0000269|PubMed:17092312}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, inflorescence stems,
CC flowers, siliques, dry seeds and mature cauline leaves.
CC {ECO:0000269|PubMed:11489192, ECO:0000269|PubMed:17092312}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryo development and after
CC the bolting stage, in mature culine leaves and in flowers. Not
CC detected at the protein level at the rosette stage of development.
CC {ECO:0000269|PubMed:11489192}.
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DR EMBL; AF026167; AAD55746.1; -; mRNA.
DR EMBL; AB010699; BAB10897.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94515.1; -; Genomic_DNA.
DR EMBL; AY063792; AAL36099.1; -; mRNA.
DR EMBL; AY117280; AAM51355.1; -; mRNA.
DR RefSeq; NP_198832.1; NM_123380.3.
DR UniGene; At.48057; -.
DR UniGene; At.68513; -.
DR UniGene; At.70297; -.
DR ProteinModelPortal; Q9SQK3; -.
DR SMR; Q9SQK3; -.
DR BioGrid; 19265; 5.
DR IntAct; Q9SQK3; 4.
DR STRING; 3702.AT5G40160.1; -.
DR PaxDb; Q9SQK3; -.
DR EnsemblPlants; AT5G40160.1; AT5G40160.1; AT5G40160.
DR GeneID; 834014; -.
DR Gramene; AT5G40160.1; AT5G40160.1; AT5G40160.
DR KEGG; ath:AT5G40160; -.
DR Araport; AT5G40160; -.
DR TAIR; locus:2173767; AT5G40160.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; COG0666; LUCA.
DR HOGENOM; HOG000241764; -.
DR InParanoid; Q9SQK3; -.
DR OMA; QNEKPNL; -.
DR OrthoDB; EOG09360CBT; -.
DR PhylomeDB; Q9SQK3; -.
DR Reactome; R-ATH-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-ATH-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-ATH-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-ATH-5632684; Hedgehog 'on' state.
DR Reactome; R-ATH-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-ATH-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-ATH-5689603; UCH proteinases.
DR Reactome; R-ATH-5689880; Ub-specific processing proteases.
DR Reactome; R-ATH-68949; Orc1 removal from chromatin.
DR Reactome; R-ATH-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-ATH-69229; Ubiquitin-dependent degradation of Cyclin D1.
DR Reactome; R-ATH-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-ATH-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q9SQK3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR Genevisible; Q9SQK3; AT.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat; Chloroplast; Complete proteome; Plastid;
KW Reference proteome; Repeat; Transit peptide.
FT TRANSIT 1 39 Chloroplast. {ECO:0000255}.
FT CHAIN 40 315 Ankyrin repeat domain-containing protein
FT EMB506, chloroplastic.
FT /FTId=PRO_0000313815.
FT REPEAT 151 180 ANK 1.
FT REPEAT 184 213 ANK 2.
FT REPEAT 217 246 ANK 3.
FT REPEAT 250 279 ANK 4.
FT REPEAT 283 307 ANK 5.
FT COMPBIAS 81 133 Glu-rich.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 151 307 iprf:ANK_REP_REGION [T]
FT MYHIT 217 246 ismart:ANK [T]
FT MYHIT 184 216 iprf:ANK_REPEAT [T]
FT MYHIT 199 280 ipfam:Ank_2 [T]
FT MYHIT 184 213 ismart:ANK [T]
FT MYHIT 250 279 ismart:ANK [T]
FT MYHIT 151 180 ismart:ANK [T]
FT MYHIT 217 249 iprf:ANK_REPEAT [T]
FT MYHIT 250 282 iprf:ANK_REPEAT [T]
SQ SEQUENCE 315 AA; 35461 MW; B13F9C8D1850E714 CRC64;
MVSSVLSIPP QTCLLPRLPI SDSVNCKSKI VYCLSTSVRG SSVKRQSTAR TRSFTETNRR
TPSVQSKHEF WEDPDDGSDS ENEYEGEEED GIGNDLDNES DWEDDSRVQK LTTTDNYEEE
LAKEVEQLLE PEERVILQQN EKPNLKMIST KSWKPLQTLA LSMQIQLMDN LIENGLDIDD
VDKDNQTALH KAIIGKKEAV ISHLLRKGAN PHLQDRDGAA PIHYAVQVGA LQTVKLLFKY
NVDVNVADNE GWTPLHIAVQ SRNRDITKIL LTNGADKTRR TKDGKLALDL ALCFGRDFKS
YDLVKLLKIM PTGDI
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