Entry euk:E7FEK4_DANRE

ID   E7FEK4_DANRE            Unreviewed;      1453 AA.
AC   E7FEK4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 2.
DT   10-MAY-2017, entry version 50.
DE   SubName: Full=Zgc:171446 {ECO:0000313|Ensembl:ENSDARP00000100381};
GN   ORFNames=zgc:171446 {ECO:0000313|Ensembl:ENSDARP00000100381,
GN   ECO:0000313|ZFIN:ZDB-GENE-080205-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000100381, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000100381}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100381};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000100381, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100381,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000100381}.
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DR   EMBL; BX322654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000104033; -.
DR   PaxDb; E7FEK4; -.
DR   PeptideAtlas; E7FEK4; -.
DR   Ensembl; ENSDART00000110995; ENSDARP00000100381; ENSDARG00000076366.
DR   ZFIN; ZDB-GENE-080205-1; zgc:171446.
DR   eggNOG; ENOG410KCRJ; Eukaryota.
DR   eggNOG; COG2373; LUCA.
DR   GeneTree; ENSGT00760000118982; -.
DR   OMA; RITTHAH; -.
DR   Proteomes; UP000000437; Chromosome 3.
DR   Bgee; ENSDARG00000076366; -.
DR   ExpressionAtlas; E7FEK4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 2.60.40.690; -; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR011626; A2M_comp.
DR   InterPro; IPR002890; A2M_N.
DR   InterPro; IPR011625; A2M_N_2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07678; A2M_comp; 1.
DR   Pfam; PF01835; A2M_N; 1.
DR   Pfam; PF07703; A2M_N_2; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF10569; Thiol-ester_cl; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   SUPFAM; SSF49410; SSF49410; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7FEK4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1453       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005910982.
FT   DOMAIN      479    627       A2M_N_2. {ECO:0000259|SMART:SM01359}.
FT   DOMAIN      747    836       A2M. {ECO:0000259|SMART:SM01360}.
FT   DOMAIN     1359   1448       A2M_recep. {ECO:0000259|SMART:SM01361}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT      1359   1448       ipfam:A2M_recep [T]
FT   MYHIT       146    237       ipfam:A2M_N [T]
FT   MYHIT       480    627       ipfam:A2M_N_2 [T]
FT   MYHIT       968    997       ipfam:Thiol-ester_cl [T]
FT   MYHIT       747    836       ismart:A2M [T]
FT   MYHIT      1017   1249       ipfam:A2M_comp [T]
FT   MYHIT       976    984       ipat:ALPHA_2_MACROGLOBULIN [T]
FT   MYHIT       479    627       ismart:A2M_N_2 [T]
FT   MYHIT      1359   1448       ismart:A2M_recep [T]
FT   MYHIT       747    835       ipfam:A2M [T]
SQ   SEQUENCE   1453 AA;  158313 MW;  9D4A1A41289085AB CRC64;
     MAMMEISVWK WINLVLFFCF VDGAMFALEA PRPREPVVTA DEQISGPLFM VTFPSLIESG
     SGAKLCASLL KPQGSLTITI TLIDDKNTET QLARQTTQRK LHRCFNFQAP LVNGDSVQTV
     RVVVQGQSFK MTEERKVMFR SYLPLTFIQT DKPLYNPGQT VNFRVVTMSD KLVPLDQMYN
     LVVLEDFRNI RINQWTNVSS VNWILELSHV LIPEAQVGTY TLRAYIGDRI ISQSFDVKQY
     VLPKFDVTVN APQTYSVADV GLKVEACGKY TFGQPVPGQV LVQVCRQPLT YVQDPKVTSI
     CLNKSTKTNN TGCASLTLST SSFFGTSFES NLQNSFIVNV NLTEEGTGVV MSKSTTVSIT
     FEVGKVTFVD LPKFYNYGST VNGKISVSDF NGNPIYNKAV YLLDSSIWPN KLLFNLTTNN
     NGFAKFSLDT TSFPQADLNL VASATPQSYF SSNSPYFTTD SQVVQLSQTD PDTPTFSDLS
     IVKLEQPLKC GTTYSVTVKY LFVGETGDYS ADIIYMVMSR GVIVLHGFKT VQARASNTLT
     KGTVTFDLSI LAKMAPMVQI LVYSVLPSQT VVTGSASFDT EKCFSNQVSL QFSPATAVPG
     EGSILTVSAQ AGSLCGLSAI DQSVLIMQSG GRLSAEAVFN MLPLQSLSDY PYGAEDQQNC
     LNVRPRRAVP TDQAYNTFKS VGMKMATNLP VREPECLKFK DLLYYRNFWG VRDAVFAMAE
     KAPVSLAMAG TGGSSVDLTI RTYFPETWIW QLSLVGDSGS TSVPLTVPDT ITTWDTEAFC
     LSSNGFGLAP PVLLTSFQPF FLELTLPYSI IRGEAFELVA TVFNYLLQCI KIQVTPTPSS
     NYTLTPINDQ SSSTLSTNWR KTIKWALTAS VIGTVNVTIS AEASPSQELC GDQDVTVPSR
     GRIDIVTRSL RVLAEGVERT FTRSWLLCPK GSMLSESVKI TLPTNVIQGS ASCSVSVIGD
     IMGRALNNLA NLLQMPSGCG EQNMIILAPN VYILRYLTVT AQLTPAIRDT ATGYLLTGYQ
     GQLNYRHSDG SFSTFGYDPS NTWLTAFVMR TFGLARSFTY IDPNVLAGAK NWLISTQGSD
     GCFVQQGTLY HNDMKGGVGD NVTMTGYIVA SLLEIGVPVT DPVITKALSF LRPLVGNLGN
     TYVTALLAHT FSLAGETNTR AQLLSSLRNT AISEGTTLHW SQTTSGDTLA VEISAYVLLA
     VLTVQPVTTA NLGYANRIVN WIVAQQNPYG GFSSTQDTVV ALQALALYAA QAFTPGGSST
     VTVQSSVPAG DIFNFAVTPN NRLLYQRNSL NNFPGTYSVV ARGSACASVQ VACFYNIPTP
     VMVARTLSVV AKVSGDCQAA PVNLMLTFTV KYNGRKPTTN MVLVDIKVLS GFTADTSLLG
     SPPNFAPLVQ RVDSNGDHVL VYLQEVPKGV PVTFSIQLTQ TVAVQNLKPA VINIYDYYQR
     NDKFETTYKS PCP
//