ID DB134_HUMAN Reviewed; 66 AA.
AC Q4QY38; A1L4A4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 15-MAR-2017, entry version 84.
DE RecName: Full=Beta-defensin 134;
DE AltName: Full=Defensin, beta 134;
DE Flags: Precursor;
GN Name=DEFB134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the
RT male reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Patil A., Zhang G.;
RT "Genome-wide analysis of rat beta-defensins: evidence for the
RT existence of four syntenic defensin gene clusters in mammals.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: Was termed (Ref.2) DEFB135. {ECO:0000305}.
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DR EMBL; DQ012024; AAY59760.1; -; mRNA.
DR EMBL; AY621331; AAT51870.1; -; mRNA.
DR EMBL; BC130461; AAI30462.1; -; mRNA.
DR EMBL; BC130463; AAI30464.1; -; mRNA.
DR CCDS; CCDS34847.1; -.
DR RefSeq; NP_001289624.1; NM_001302695.1.
DR RefSeq; XP_016869213.1; XM_017013724.1.
DR RefSeq; XP_016885980.1; XM_017030491.1.
DR RefSeq; XP_016885981.1; XM_017030492.1.
DR RefSeq; XP_016885982.1; XM_017030493.1.
DR UniGene; Hs.631852; -.
DR UniGene; Hs.98232; -.
DR ProteinModelPortal; Q4QY38; -.
DR SMR; Q4QY38; -.
DR STRING; 9606.ENSP00000435010; -.
DR BioMuta; DEFB134; -.
DR DMDM; 74762871; -.
DR PaxDb; Q4QY38; -.
DR PRIDE; Q4QY38; -.
DR DNASU; 613211; -.
DR Ensembl; ENST00000382205; ENSP00000371640; ENSG00000205882.
DR Ensembl; ENST00000526438; ENSP00000435010; ENSG00000205882.
DR GeneID; 105379765; -.
DR GeneID; 613211; -.
DR KEGG; hsa:105379765; -.
DR KEGG; hsa:613211; -.
DR UCSC; uc011kxn.3; human.
DR CTD; 613211; -.
DR GeneCards; DEFB134; -.
DR HGNC; HGNC:32399; DEFB134.
DR neXtProt; NX_Q4QY38; -.
DR OpenTargets; ENSG00000205882; -.
DR PharmGKB; PA164718735; -.
DR eggNOG; ENOG410JFD3; Eukaryota.
DR eggNOG; ENOG41118XV; LUCA.
DR GeneTree; ENSGT00400000024366; -.
DR HOGENOM; HOG000112164; -.
DR HOVERGEN; HBG079896; -.
DR InParanoid; Q4QY38; -.
DR OMA; FQLECCI; -.
DR OrthoDB; EOG091G14QD; -.
DR PhylomeDB; Q4QY38; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR GenomeRNAi; 613211; -.
DR PRO; PR:Q4QY38; -.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000205882; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR025933; Beta_defensin.
DR PANTHER; PTHR15001; PTHR15001; 1.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1 19 {ECO:0000255}.
FT CHAIN 20 66 Beta-defensin 134.
FT /FTId=PRO_0000045360.
FT DISULFID 32 58 {ECO:0000250}.
FT DISULFID 38 52 {ECO:0000250}.
FT DISULFID 42 59 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 31 59 ipfam:Defensin_beta_2 [T]
SQ SEQUENCE 66 AA; 7552 MW; DA47541B373E1990 CRC64;
MKPLLVVFVF LFLWDPVLAG INSLSSEMHK KCYKNGICRL ECYESEMLVA YCMFQLECCV
KGNPAP
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