ID D4AC62_RAT Unreviewed; 295 AA.
AC D4AC62;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 10-MAY-2017, entry version 56.
DE SubName: Full=Keratin 222 {ECO:0000313|Ensembl:ENSRNOP00000014414};
DE SubName: Full=RCG34143 {ECO:0000313|EMBL:EDM05978.1};
GN Name=Krt222 {ECO:0000313|Ensembl:ENSRNOP00000014414,
GN ECO:0000313|RGD:1560383};
GN Synonyms=RGD1560383 {ECO:0000313|RGD:1560383};
GN ORFNames=rCG_34143 {ECO:0000313|EMBL:EDM05978.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000014414, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000014414, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014414,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into
RT mammalian evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:EDM05978.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDM05978.1};
RX PubMed=15632090; DOI=10.1101/gr.2889405;
RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA Istrail S., Li P., Sutton G.;
RT "Gene and alternative splicing annotation with AIR.";
RL Genome Res. 15:54-66(2005).
RN [3] {ECO:0000313|EMBL:EDM05978.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDM05978.1};
RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000014414}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014414};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685, ECO:0000256|SAAS:SAAS00547919}.
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DR EMBL; AC096439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473948; EDM05978.1; -; Genomic_DNA.
DR RefSeq; XP_001081416.1; XM_001081416.6.
DR RefSeq; XP_003750971.1; XM_003750923.4.
DR Ensembl; ENSRNOT00000014414; ENSRNOP00000014414; ENSRNOG00000010839.
DR GeneID; 497994; -.
DR KEGG; rno:497994; -.
DR CTD; 125113; -.
DR RGD; 1560383; Krt222.
DR eggNOG; ENOG410IEQR; Eukaryota.
DR eggNOG; ENOG410YA01; LUCA.
DR GeneTree; ENSGT00770000120671; -.
DR OMA; DEGCLQT; -.
DR OrthoDB; EOG091G0F2M; -.
DR TreeFam; TF332442; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000010839; -.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR001664; IF.
DR InterPro; IPR018039; Intermediate_filament_CS.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR PROSITE; PS00226; IF; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAAS:SAAS00031873, ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW Intermediate filament {ECO:0000256|RuleBase:RU000685,
KW ECO:0000256|SAAS:SAAS00031864};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT COILED 41 75 {ECO:0000256|SAM:Coils}.
FT COILED 87 149 {ECO:0000256|SAM:Coils}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 2 149 ipfam:Filament [T]
FT MYHIT 136 144 ipat:IF [T]
SQ SEQUENCE 295 AA; 34034 MW; F0180B858398BB82 CRC64;
MELSQLLNEI RANYEQLLTR NQIDTVLSTR IQLEEDLTKK MDKDGEALKA AQAELKEARR
QCHHLQVEIE SLHAVERGLE NSLQASEQHY QMQLQDLESV IGRLEKELQE VRRGIERQLQ
EHEMLLNTKM RLEQEIATYR RLLEQEEIRY YGCIQGERKE DKPAKSKVGF LLPSAIINEI
SFSTKVSHKY ENESVETVTK QAVVNGDVAK ESAEAHGTIQ TEKVDEVIKE WEGSFFKDNP
RLRKKSVSLR FDLHLAATDE GCLESRQDNL PDIEVRLIMR RSCSIPSIKP PPGTN
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