Entry euk:D4AB75_RAT

ID   D4AB75_RAT              Unreviewed;      1039 AA.
AC   D4AB75;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   10-MAY-2017, entry version 58.
DE   SubName: Full=Zinc finger protein 217 {ECO:0000313|Ensembl:ENSRNOP00000029826};
DE   SubName: Full=Zinc finger protein 217 (Predicted) {ECO:0000313|EMBL:EDL96338.1};
GN   Name=Zfp217 {ECO:0000313|Ensembl:ENSRNOP00000029826,
GN   ECO:0000313|RGD:1308451};
GN   Synonyms=Zfp217_predicted {ECO:0000313|EMBL:EDL96338.1};
GN   ORFNames=rCG_32252 {ECO:0000313|EMBL:EDL96338.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000029826, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000029826, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029826,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL96338.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL96338.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL96338.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL96338.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000029826}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029826};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [6] {ECO:0000313|Ensembl:ENSRNOP00000070336}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070336};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AABR07054687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07054688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474005; EDL96338.1; -; Genomic_DNA.
DR   RefSeq; NP_001101283.1; NM_001107813.1.
DR   RefSeq; XP_017447295.1; XM_017591806.1.
DR   RefSeq; XP_017447296.1; XM_017591807.1.
DR   RefSeq; XP_017447297.1; XM_017591808.1.
DR   RefSeq; XP_017447298.1; XM_017591809.1.
DR   RefSeq; XP_017447299.1; XM_017591810.1.
DR   RefSeq; XP_017447300.1; XM_017591811.1.
DR   RefSeq; XP_017447301.1; XM_017591812.1.
DR   RefSeq; XP_017447302.1; XM_017591813.1.
DR   RefSeq; XP_017447303.1; XM_017591814.1.
DR   RefSeq; XP_017447304.1; XM_017591815.1.
DR   RefSeq; XP_017447305.1; XM_017591816.1.
DR   UniGene; Rn.214135; -.
DR   STRING; 10116.ENSRNOP00000029826; -.
DR   Ensembl; ENSRNOT00000034669; ENSRNOP00000029826; ENSRNOG00000021787.
DR   Ensembl; ENSRNOT00000081593; ENSRNOP00000070336; ENSRNOG00000021787.
DR   GeneID; 311764; -.
DR   KEGG; rno:311764; -.
DR   CTD; 228913; -.
DR   RGD; 1308451; Zfp217.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00530000063100; -.
DR   OMA; EHSKVHT; -.
DR   TreeFam; TF332241; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000021787; -.
DR   GO; GO:0000118; C:histone deacetylase complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
DR   GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
DR   GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN      121    148       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      149    176       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      208    235       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      383    410       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      478    505       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      506    533       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
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CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        57     80       ismart:ZnF_C2H2 [T]
FT   MYHIT       478    505       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       506    528       ismart:ZnF_C2H2 [T]
FT   MYHIT       385    405       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       383    410       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       480    500       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       383    405       ismart:ZnF_C2H2 [T]
FT   MYHIT       151    171       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       506    533       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       149    171       ismart:ZnF_C2H2 [T]
FT   MYHIT       149    176       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       121    143       ismart:ZnF_C2H2 [T]
FT   MYHIT       208    235       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        59     80       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       708    731       ismart:ZnF_C2H2 [T]
FT   MYHIT       210    230       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       208    230       ismart:ZnF_C2H2 [T]
FT   MYHIT       121    148       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       478    500       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   1039 AA;  113160 MW;  B5728C1ED5B1D6EF CRC64;
     MPTQSLLVYM DGPEVLGSSL GTQMEVDDAV PMKGPAVVPF RAAQEKSLAT AEGHMPLDCM
     FCSQVFSHAE DLNQHVLLQH RPTLCEPAVL RVEAEYLSPL DKGQVPTEPP KEKSSKEMEE
     LSCDVCGQTF PVAFDVESHM KKHKDSFTYG CSMCGRRFKE PWFLKNHMRT HNGKSGTRSK
     LQQGTESPVT INDVVQAHAP GNISTPYKIC MVCGFLFPNK QSLIEHSKVH AKETVPSASS
     TAPDGHQEEP TSPREELLQF LNLRPRSTAE STVKPMTSIP QLDPFTTYQA WQLATKGKVA
     VAQEEVKESG QEGSTDNDDS CSEKEELGEI WVGGKVEGSG KSKTNRSSCS GLSQDKDKSR
     HGNSEVPSGD ADSKLPGSKE KPTHCSECSK AFRTYHQLVL HSRVHRKDRR ADAPSPTMAG
     DARQPGTCSP ELRTTLEESG AGDREGGSED GSEDGLPEGL HLDKNDDGGK AKPLTSSREC
     SYCGKFFRSN YYLNIHLRTH TGEKPYKCEF CEYAAAQKTS LRYHLERHHK DKQLGDAPAE
     SKSEGRSQEP QDMLLTADSA QTKNLKRFLD GAKDVKGSPP AKLLKEMPSV FQSVLGSTVL
     SPAHNKDTQD FHKNAADGAE KVRKSPAPAY LDMPRKKTGD PRASSPACKL EGVGPLAREA
     GHGEKMDREA DYRHKPGADC QDRPLNLSLG ALHACPAISL SKCLIPSIAC PFCTFKTFYP
     EVLMMHQRLE HRYNPDTHKN CSSKSVLRNR RTGCPPALLG KDVPPLSGLH KPKAKPAFSS
     QAKALHPEKV RQGTSGPGKA PQTSGPDNST LAPSNLKSHR SQPSAGGPSA TRQQQSELFP
     KGGVPAAMDK AKRPEPKLKA PPAPPAQSPL SSGNGNGSAE CPWGQQGRDY YCQRNAGSAT
     SEYSEPHPKR LKSPVVSLDT EHPGPNGRRG FELPKYHVVR SITSLLPPEY VCSPPVLPPK
     ARFLSPGEVE SPSVLTVQKP YGASGPLYTC GPVGHAGASP SLEGKRPVSY QHLSNSMLQR
     RNCENFIGNT HYRPNDKKS
//