ID D3ZAK3_RAT Unreviewed; 977 AA.
AC D3ZAK3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 10-MAY-2017, entry version 61.
DE SubName: Full=Zinc finger protein 445 {ECO:0000313|Ensembl:ENSRNOP00000036378};
GN Name=Zfp445 {ECO:0000313|Ensembl:ENSRNOP00000036378,
GN ECO:0000313|RGD:1559144};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000036378, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000036378, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036378,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into
RT mammalian evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000036378}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036378};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC ProRule:PRU00187, ECO:0000256|SAAS:SAAS00772597}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000036378}.
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DR EMBL; AABR07071813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001178731.1; NM_001191802.1.
DR UniGene; Rn.100996; -.
DR ProteinModelPortal; D3ZAK3; -.
DR STRING; 10116.ENSRNOP00000036378; -.
DR PaxDb; D3ZAK3; -.
DR Ensembl; ENSRNOT00000034690; ENSRNOP00000036378; ENSRNOG00000025554.
DR GeneID; 301076; -.
DR KEGG; rno:301076; -.
DR UCSC; RGD:1559144; rat.
DR CTD; 235682; -.
DR RGD; 1559144; Zfp445.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00870000136584; -.
DR InParanoid; D3ZAK3; -.
DR KO; K09229; -.
DR OMA; RHMKNHI; -.
DR OrthoDB; EOG091G02KC; -.
DR TreeFam; TF350827; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000025554; -.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW Metal-binding {ECO:0000256|SAAS:SAAS00780264};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187,
KW ECO:0000256|SAAS:SAAS00772585};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|SAAS:SAAS00780289};
KW Transcription {ECO:0000256|SAAS:SAAS00772592};
KW Transcription regulation {ECO:0000256|SAAS:SAAS00772592};
KW Zinc {ECO:0000256|SAAS:SAAS00780264};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00780264}.
FT DOMAIN 53 135 SCAN box. {ECO:0000259|PROSITE:PS50804}.
FT DOMAIN 213 283 KRAB. {ECO:0000259|PROSITE:PS50805}.
FT DOMAIN 460 487 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 488 515 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 543 570 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 571 598 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 624 651 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 652 677 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 708 735 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 736 763 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 786 813 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 814 841 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 924 951 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 952 977 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 49 136 ipfam:SCAN [T]
FT MYHIT 736 763 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 49 161 ismart:SCAN [T]
FT MYHIT 213 283 iprf:KRAB [T]
FT MYHIT 708 730 ismart:ZnF_C2H2 [T]
FT MYHIT 814 836 ismart:ZnF_C2H2 [T]
FT MYHIT 460 487 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 788 808 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 816 836 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 488 515 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 954 974 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 488 510 ismart:ZnF_C2H2 [T]
FT MYHIT 573 593 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 952 974 ismart:ZnF_C2H2 [T]
FT MYHIT 624 651 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 652 677 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 53 135 iprf:SCAN_BOX [T]
FT MYHIT 571 598 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 926 946 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 213 252 ipfam:KRAB [T]
FT MYHIT 626 646 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 736 758 ismart:ZnF_C2H2 [T]
FT MYHIT 543 565 ismart:ZnF_C2H2 [T]
FT MYHIT 545 565 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 924 951 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 814 841 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 543 570 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 786 813 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 490 510 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 710 730 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 654 676 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 652 676 ismart:ZnF_C2H2 [T]
FT MYHIT 708 735 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 624 646 ismart:ZnF_C2H2 [T]
FT MYHIT 571 593 ismart:ZnF_C2H2 [T]
FT MYHIT 738 758 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 924 946 ismart:ZnF_C2H2 [T]
FT MYHIT 213 272 ismart:KRAB [T]
FT MYHIT 952 977 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 460 482 ismart:ZnF_C2H2 [T]
FT MYHIT 462 482 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 786 808 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 977 AA; 113701 MW; 597148AADEDC42E0 CRC64;
MPPGRCYAAR SVQMSREHGR LHMVKKEEEE DGCISVETAR PQTLNRPGQE LFRQLFRQLR
YHESSGPLET LSRLQELCRW WMRPDVLSKA QMLELLVLEQ FLSILPGELR TWVQLHCPES
GAEVVALLEE LQRDLDGTSL KDSCLTQNPD VHWIGTGPLQ AAQIWSPASH VGKSSALEDY
LETPHGIGRG DSPAVSMPDY FQIEESIEHQ ETLTFQDVEV TFSQEEWGCL NSAQRNLYRD
VILENYGNVV SVVGSSPKPA LISWLEARKP WGMNICTVQL KREPDAAPEG GKLQIEPSKF
ILKQEPSKYT ETCVKPSGCP ASKGTGLKES FEQKSRLQKS CGDSVQMKEM KKGTDISQKA
GRKSEILRNS DILELKHVKC VSVSRKKLSF KHGYDRNFRK SSHHYNNKYG EGLRDTVEGF
GVYQNTGLKE NEKDRCGETL RKSSHSHLEY QRYYSQGSLF KCRVCEKAFK WRSNCIRHEK
IHTGVKPYKC SSCEKAFQRL STYRLHQKTH TKQKHESRKY NNALPCSLDV SHCLINQDEE
KNFYCSQCGK HFSCRSYALE HQRIHTQEKP YNCIRCRKTF RWKSNFTRHM KLHGKEVRNQ
ERCQEDFKQN YSQSQVISTI EKTFLCQSCG KTFTQKKSLI EHQRIHTGEK LYQCSGCGKT
FASRSSYIIH MKQKRHAIKI KPESGSLPFS QDTAFAIPQS GHNTEEPNQC KYCGRAFHNR
SFLLIHERIH TREKPYKCRE CEKAFRWRSN LYRHERKHFL HKRRKYHESK ETSNLQSKIF
IDEKPFWCQE CGKTFTRKRS LLDHKGIHSG ERRFKCNLCE KSFDRNYRLV NHQRIHTTEQ
PFQSQWHDKD FAGTHAHSVD QRKHRTLQSE YSLQSDKPGL SYCQDVRVNI QELELSGKKP
LDNPSHESSM STAFQNVPTK KACHKCSTCG KTFRKHSHLI SHKRCHTKER PFKCIVCGKT
FGWSSNLTRH VKSHFRD
//
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