ID D1060_DICDI Reviewed; 166 AA.
AC Q1ZXG8; O15745;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 02-NOV-2016, entry version 53.
DE RecName: Full=Probable tyrosine-protein phosphatase DG1060;
DE EC=3.1.3.48;
DE AltName: Full=Developmental gene 1060 protein;
GN Name=DG1060; ORFNames=DDB_G0281953;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
RC STRAIN=AX4;
RA Loomis W.F., Iranfar N.;
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC tyrosine + phosphate.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000044; EAS66873.1; -; Genomic_DNA.
DR EMBL; AF020278; AAB70846.1; -; Genomic_DNA.
DR RefSeq; XP_001134556.1; XM_001134556.1.
DR ProteinModelPortal; Q1ZXG8; -.
DR SMR; Q1ZXG8; -.
DR PaxDb; Q1ZXG8; -.
DR EnsemblProtists; EAS66873; EAS66873; DDB_G0281953.
DR GeneID; 8623336; -.
DR KEGG; ddi:DDB_G0281953; -.
DR dictyBase; DDB_G0281953; -.
DR eggNOG; KOG1572; Eukaryota.
DR eggNOG; COG2365; LUCA.
DR InParanoid; Q1ZXG8; -.
DR KO; K18043; -.
DR OMA; NAWDPIT; -.
DR PhylomeDB; Q1ZXG8; -.
DR PRO; PR:Q1ZXG8; -.
DR Proteomes; UP000002195; Chromosome 3.
DR Proteomes; UP000002195; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR020428; Tyr_Pase_SIW14-lik_euk.
DR InterPro; IPR004861; Tyr_Pase_SIW14-like.
DR Pfam; PF03162; Y_phosphatase2; 1.
DR PRINTS; PR01911; PFDSPHPHTASE.
DR SUPFAM; SSF52799; SSF52799; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Hydrolase; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1 166 Probable tyrosine-protein phosphatase
FT DG1060.
FT /FTId=PRO_0000368208.
FT ACT_SITE 101 101 Phosphocysteine intermediate.
FT {ECO:0000255}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 5 162 ipfam:Y_phosphatase2 [T]
SQ SEQUENCE 166 AA; 19380 MW; 632F2F84E8D17050 CRC64;
MAHHIPPLNF GMVADDLYRS GQPNELNFPF LEKLQLKKII FLAPDDPSQQ FQNFVEDQDI
ELIHLGMDTH QNPWNPISEE IVISALKIIL NPDNYPLHIM CNLGRHRTGT VVGCLRKLQR
WNLTSIFEEY RRFAGSKVKL LNEQFIELFD TDLVTYNNAP QWLYLS
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