ID CIA1_ARATH Reviewed; 352 AA.
AC O80990; F4ITL5;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 12-APR-2017, entry version 128.
DE RecName: Full=Protein CIA1 {ECO:0000303|PubMed:23104832};
DE AltName: Full=Cytosolic iron-sulfur protein assembly 1 {ECO:0000303|PubMed:23104832};
DE AltName: Full=Protein EMBRYO DEFECTIVE 1345 {ECO:0000303|PubMed:15266054};
GN Name=CIA1 {ECO:0000303|PubMed:23104832};
GN Synonyms=EMB1345 {ECO:0000303|PubMed:15266054};
GN OrderedLocusNames=At2g26060 {ECO:0000312|Araport:AT2G26060};
GN ORFNames=T19L18.13 {ECO:0000312|EMBL:AAC31230.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Portal (Araport);
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=15266054; DOI=10.1104/pp.104.045179;
RA Tzafrir I., Pena-Muralla R., Dickerman A., Berg M., Rogers R.,
RA Hutchens S., Sweeney T.C., McElver J., Aux G., Patton D., Meinke D.;
RT "Identification of genes required for embryo development in
RT Arabidopsis.";
RL Plant Physiol. 135:1206-1220(2004).
RN [6]
RP IDENTIFICATION, AND REVIEW.
RX PubMed=18493040; DOI=10.1534/genetics.107.086033;
RA Godman J., Balk J.;
RT "Genome analysis of Chlamydomonas reinhardtii reveals the existence of
RT multiple, compartmentalized iron-sulfur protein assembly machineries
RT of different evolutionary origins.";
RL Genetics 179:59-68(2008).
RN [7]
RP FUNCTION, INTERACTION WITH AE7 AND NAR1, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23104832; DOI=10.1105/tpc.112.102608;
RA Luo D., Bernard D.G., Balk J., Hai H., Cui X.;
RT "The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster
RT assembly pathway to maintain nuclear genome integrity in
RT Arabidopsis.";
RL Plant Cell 24:4135-4148(2012).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe-S)
CC protein assembly (CIA) machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000269|PubMed:23104832}.
CC -!- SUBUNIT: Part of a complex composed of AE7, CIA1, MMS19 and NAR1.
CC Interacts with AE7 and NAR1. {ECO:0000269|PubMed:23104832}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23104832}.
CC Cytoplasm {ECO:0000269|PubMed:23104832}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O80990-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O80990-2; Sequence=VSP_057803, VSP_057804;
CC Note=No experimental confirmation available. Derived from EST
CC data. {ECO:0000305};
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality when homozygous.
CC {ECO:0000269|PubMed:15266054, ECO:0000269|PubMed:23104832}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000305}.
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DR EMBL; AC004747; AAC31230.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC07790.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07791.1; -; Genomic_DNA.
DR EMBL; AY093154; AAM13153.1; -; mRNA.
DR EMBL; BT003394; AAO30057.1; -; mRNA.
DR EMBL; AY085277; AAM62509.1; -; mRNA.
DR PIR; T02617; T02617.
DR RefSeq; NP_001031421.1; NM_001036344.1. [O80990-2]
DR RefSeq; NP_565615.1; NM_128165.4. [O80990-1]
DR UniGene; At.38940; -.
DR ProteinModelPortal; O80990; -.
DR SMR; O80990; -.
DR STRING; 3702.AT2G26060.1; -.
DR PaxDb; O80990; -.
DR EnsemblPlants; AT2G26060.1; AT2G26060.1; AT2G26060. [O80990-1]
DR GeneID; 817147; -.
DR Gramene; AT2G26060.1; AT2G26060.1; AT2G26060.
DR KEGG; ath:AT2G26060; -.
DR Araport; AT2G26060; -.
DR TAIR; locus:2057381; AT2G26060.
DR eggNOG; KOG0645; Eukaryota.
DR eggNOG; ENOG410XRMA; LUCA.
DR HOGENOM; HOG000208901; -.
DR InParanoid; O80990; -.
DR OMA; WEVAGDD; -.
DR OrthoDB; EOG09360EM2; -.
DR PhylomeDB; O80990; -.
DR PRO; PR:O80990; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80990; baseline and differential.
DR Genevisible; O80990; AT.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IGI:TAIR.
DR Gene3D; 2.130.10.10; -; 3.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; Nucleus;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1 352 Protein CIA1.
FT /FTId=PRO_0000433517.
FT REPEAT 18 64 WD 1. {ECO:0000255}.
FT REPEAT 72 111 WD 2. {ECO:0000255}.
FT REPEAT 116 155 WD 3. {ECO:0000255}.
FT REPEAT 161 200 WD 4. {ECO:0000255}.
FT REPEAT 211 250 WD 5. {ECO:0000255}.
FT REPEAT 265 303 WD 6. {ECO:0000255}.
FT REPEAT 315 352 WD 7. {ECO:0000255}.
FT VAR_SEQ 329 337 EGNRLLASA -> VREPVACVG (in isoform 2).
FT /FTId=VSP_057803.
FT VAR_SEQ 338 352 Missing (in isoform 2).
FT /FTId=VSP_057804.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 107 146 ismart:WD40 [T]
FT MYHIT 9 350 ihamap:ciao1 [T]
FT MYHIT 62 102 ismart:WD40 [T]
FT MYHIT 65 102 ipfam:WD40 [T]
FT MYHIT 209 240 iprf:WD_REPEATS_2 [T]
FT MYHIT 114 147 iprf:WD_REPEATS_2 [T]
FT MYHIT 16 55 iprf:WD_REPEATS_2 [T]
FT MYHIT 13 54 ipfam:WD40 [T]
FT MYHIT 16 352 iprf:WD_REPEATS_REGION [T]
FT MYHIT 159 190 iprf:WD_REPEATS_2 [T]
FT MYHIT 311 346 ipfam:WD40 [T]
FT MYHIT 255 294 ismart:WD40 [T]
FT MYHIT 9 55 ismart:WD40 [T]
FT MYHIT 313 352 iprf:WD_REPEATS_2 [T]
FT MYHIT 198 241 ismart:WD40 [T]
FT MYHIT 70 102 iprf:WD_REPEATS_2 [T]
FT MYHIT 152 191 ismart:WD40 [T]
FT MYHIT 109 145 ipfam:WD40 [T]
FT MYHIT 154 190 ipfam:WD40 [T]
FT MYHIT 200 240 ipfam:WD40 [T]
FT MYHIT 133 147 ipat:WD_REPEATS_1 [T]
FT MYHIT 306 347 ismart:WD40 [T]
SQ SEQUENCE 352 AA; 39131 MW; DA691BB99CD67E12 CRC64;
MDLMEKNLEL VEIQKLEGHT DRVWSVAWNP VSSHADGVSP ILASCSGDNT VRIWEQSSLS
RSWTCKTVLE ETHTRTVRSC AWSPSGQLLA TASFDGTTGI WKNYGSEFEC ISTLEGHENE
VKSVSWNASG SCLATCSRDK SVWIWEVLEG NEYDCAAVLT GHTQDVKMVQ WHPTMDVLFS
CSYDNTIKVW WSEDDDGEYQ CVQTLGESNN GHSSTVWSIS FNAAGDKMVT CSDDLTLKIW
GTDIAKMQSG EEYAPWIHLC TLSGYHDRTI YSAHWSRDDI IASGAGDNAI RLFVDSKHDS
VDGPSYNLLL KKNKAHENDV NSVQWSPGEG NRLLASASDD GMVKIWQLAT KP
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