Entry euk:CF251_CHLRE

ID   CF251_CHLRE             Reviewed;         815 AA.
AC   A8IRK7;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   10-MAY-2017, entry version 44.
DE   RecName: Full=Cilia- and flagella-associated protein 251 {ECO:0000305};
DE   AltName: Full=Flagellar-associated protein 251 {ECO:0000305};
GN   Name=CFAP251 {ECO:0000305};
GN   Synonyms=FAP251 {ECO:0000303|PubMed:17967944};
GN   ORFNames=CHLREDRAFT_145396 {ECO:0000312|EMBL:EDP04324.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
OC   Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
RA   Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
RA   Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
RA   Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
RA   Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
RA   Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
RA   Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
RA   Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
RA   Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
RA   Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
RA   Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
RA   Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
RA   Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
RA   Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
RA   Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
RA   Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
RA   Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
RA   Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
RA   Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and
RT   plant functions.";
RL   Science 318:245-250(2007).
RN   [2]
RP   FUNCTION, IDENTIFICATION IN A COMPLEX CONTAINING CFAP61; CFAP91 AND
RP   CFAP251, SUBCELLULAR LOCATION, AND INTERACTION WITH CALMODULIN.
RX   PubMed=17967944; DOI=10.1083/jcb.200703107;
RA   Dymek E.E., Smith E.F.;
RT   "A conserved CaM- and radial spoke associated complex mediates
RT   regulation of flagellar dynein activity.";
RL   J. Cell Biol. 179:515-526(2007).
CC   -!- FUNCTION: As component of a spoke-associated complex, regulates
CC       flagellar dynein activity by mediating regulatory signals between
CC       the radial spokes and dynein arms. {ECO:0000269|PubMed:17967944}.
CC   -!- SUBUNIT: Identified in a spoke-associated complex containing
CC       CFAP61, CFAP91 and CFAP251; the complex is associated with the
CC       radial spokes in the axoneme (PubMed:17967944). The complex
CC       associates with Calmodulin; the association is calcium sensitive
CC       (PubMed:17967944). {ECO:0000269|PubMed:17967944}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000269|PubMed:17967944}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DS496121; EDP04324.1; -; Genomic_DNA.
DR   RefSeq; XP_001691834.1; XM_001691782.1.
DR   UniGene; Cre.11652; -.
DR   ProteinModelPortal; A8IRK7; -.
DR   STRING; 3055.EDP04324; -.
DR   PaxDb; A8IRK7; -.
DR   EnsemblPlants; EDP04324; EDP04324; CHLREDRAFT_145396.
DR   GeneID; 5717442; -.
DR   Gramene; EDP04324; EDP04324; CHLREDRAFT_145396.
DR   KEGG; cre:CHLREDRAFT_145396; -.
DR   eggNOG; ENOG410JR21; Eukaryota.
DR   eggNOG; ENOG410XQRH; LUCA.
DR   InParanoid; A8IRK7; -.
DR   Proteomes; UP000006906; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50978; SSF50978; 3.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton;
KW   Flagellum; Reference proteome; Repeat; WD repeat.
FT   CHAIN         1    815       Cilia- and flagella-associated protein
FT                                251.
FT                                /FTId=PRO_0000439533.
FT   REPEAT       58     99       WD 1. {ECO:0000255}.
FT   REPEAT      103    148       WD 2. {ECO:0000255}.
FT   REPEAT      166    205       WD 3. {ECO:0000255}.
FT   REPEAT      218    257       WD 4. {ECO:0000255}.
FT   REPEAT      271    308       WD 5. {ECO:0000255}.
FT   REPEAT      379    418       WD 6. {ECO:0000255}.
FT   REPEAT      420    460       WD 7. {ECO:0000255}.
FT   REPEAT      463    502       WD 8. {ECO:0000255}.
FT   REPEAT      511    553       WD 9. {ECO:0000255}.
FT   REPEAT      573    612       WD 10. {ECO:0000255}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       209    248       ismart:WD40 [T]
FT   MYHIT       374    409       ismart:WD40 [T]
FT   MYHIT       262    299       ismart:WD40 [T]
FT   MYHIT        49     90       ismart:WD40 [T]
FT   MYHIT        93    139       ismart:WD40 [T]
FT   MYHIT       157    196       ismart:WD40 [T]
FT   MYHIT       454    493       ismart:WD40 [T]
FT   MYHIT       502    544       ismart:WD40 [T]
FT   MYHIT       555    603       ismart:WD40 [T]
SQ   SEQUENCE   815 AA;  87630 MW;  AAB6DC4839007F83 CRC64;
     MAEEQTALSL SWVFGASAHV KHGVVNLSDG YTDKICYLAA NTAVIYDKRL RRQLFLQGHT
     SPITCIVTTE DRSHVVTADT GPEALLVVWN VRTGLPTRTV QQPHRHGVST MDMSADGQWL
     ATVSAADPES GEQEVSLWSM AALLTPPEAA PPGQGPLRPL VTTLVPAGDV QHSIRFSPNN
     PAELISNGRR RVYFWSWAPG SPRFQYYSPP LRSRDFKQSV GDFVSSVFVP GTTQALTATT
     DGDLVVWDEQ GIAAQVGTSA TDRRAIKLMR IHNCPITLLA TVGDFIVSGG EDGYVRFFDP
     LLRIVAWFED LAAGPVTSVA FSAVLPDRLA HADAADTLNR FMVPDFVVAT RNSRIVSVQS
     ASFEEYDADR RRGSSVLDSL LADVVDLAAH PTRAEFAVLG RDGGLQRWDS IAHCLLGGRA
     FERQVGACLT YSRDGSLLVV GFGSGHLHIL NADDCSDLYV MRNTAAGLVR VAVSNTGKHI
     AAADENHQLL LYAYLPYKHT MRWEYVGRCR SHHGPIASVV FGESPSGQTR LLSVGGDGRV
     VEYDLAASSV AAGVQVASFY DFPPGGGAPT SLSFAPPLAY FQAFAADTHL LVSGADGTVA
     SWDINTAPLE RSATAAEGAG GEARWAAVLG DPDLLREMRD YFVYAQIKTQ GEDALEPRDV
     PGTVPVDLVP DLMRSAGFYP SESDIDNLLH HVQYMAHSRN MESLEVVTLA DLLCLYINHR
     PLFNVTHADI VAAFRELGGR GDPGSCVPKL SREQLLSLLQ STGEPMSGEE LTAALAALTG
     AHTPEKSMPV SVAAEQFSAD VLGFDTTEAG AEAAT
//