ID CF251_CHLRE Reviewed; 815 AA.
AC A8IRK7;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 10-MAY-2017, entry version 44.
DE RecName: Full=Cilia- and flagella-associated protein 251 {ECO:0000305};
DE AltName: Full=Flagellar-associated protein 251 {ECO:0000305};
GN Name=CFAP251 {ECO:0000305};
GN Synonyms=FAP251 {ECO:0000303|PubMed:17967944};
GN ORFNames=CHLREDRAFT_145396 {ECO:0000312|EMBL:EDP04324.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
OC Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
RA Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
RA Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
RA Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
RA Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
RA Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
RA Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
RA Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
RA Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
RA Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
RA Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
RA Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
RA Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
RA Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
RA Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
RA Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
RA Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
RA Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
RA Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and
RT plant functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, IDENTIFICATION IN A COMPLEX CONTAINING CFAP61; CFAP91 AND
RP CFAP251, SUBCELLULAR LOCATION, AND INTERACTION WITH CALMODULIN.
RX PubMed=17967944; DOI=10.1083/jcb.200703107;
RA Dymek E.E., Smith E.F.;
RT "A conserved CaM- and radial spoke associated complex mediates
RT regulation of flagellar dynein activity.";
RL J. Cell Biol. 179:515-526(2007).
CC -!- FUNCTION: As component of a spoke-associated complex, regulates
CC flagellar dynein activity by mediating regulatory signals between
CC the radial spokes and dynein arms. {ECO:0000269|PubMed:17967944}.
CC -!- SUBUNIT: Identified in a spoke-associated complex containing
CC CFAP61, CFAP91 and CFAP251; the complex is associated with the
CC radial spokes in the axoneme (PubMed:17967944). The complex
CC associates with Calmodulin; the association is calcium sensitive
CC (PubMed:17967944). {ECO:0000269|PubMed:17967944}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:17967944}.
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DR EMBL; DS496121; EDP04324.1; -; Genomic_DNA.
DR RefSeq; XP_001691834.1; XM_001691782.1.
DR UniGene; Cre.11652; -.
DR ProteinModelPortal; A8IRK7; -.
DR STRING; 3055.EDP04324; -.
DR PaxDb; A8IRK7; -.
DR EnsemblPlants; EDP04324; EDP04324; CHLREDRAFT_145396.
DR GeneID; 5717442; -.
DR Gramene; EDP04324; EDP04324; CHLREDRAFT_145396.
DR KEGG; cre:CHLREDRAFT_145396; -.
DR eggNOG; ENOG410JR21; Eukaryota.
DR eggNOG; ENOG410XQRH; LUCA.
DR InParanoid; A8IRK7; -.
DR Proteomes; UP000006906; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR017986; WD40_repeat_dom.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50978; SSF50978; 3.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton;
KW Flagellum; Reference proteome; Repeat; WD repeat.
FT CHAIN 1 815 Cilia- and flagella-associated protein
FT 251.
FT /FTId=PRO_0000439533.
FT REPEAT 58 99 WD 1. {ECO:0000255}.
FT REPEAT 103 148 WD 2. {ECO:0000255}.
FT REPEAT 166 205 WD 3. {ECO:0000255}.
FT REPEAT 218 257 WD 4. {ECO:0000255}.
FT REPEAT 271 308 WD 5. {ECO:0000255}.
FT REPEAT 379 418 WD 6. {ECO:0000255}.
FT REPEAT 420 460 WD 7. {ECO:0000255}.
FT REPEAT 463 502 WD 8. {ECO:0000255}.
FT REPEAT 511 553 WD 9. {ECO:0000255}.
FT REPEAT 573 612 WD 10. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 555 603 ismart:WD40 [T]
FT MYHIT 157 196 ismart:WD40 [T]
FT MYHIT 49 90 ismart:WD40 [T]
FT MYHIT 454 493 ismart:WD40 [T]
FT MYHIT 502 544 ismart:WD40 [T]
FT MYHIT 209 248 ismart:WD40 [T]
FT MYHIT 374 409 ismart:WD40 [T]
FT MYHIT 93 139 ismart:WD40 [T]
FT MYHIT 262 299 ismart:WD40 [T]
SQ SEQUENCE 815 AA; 87630 MW; AAB6DC4839007F83 CRC64;
MAEEQTALSL SWVFGASAHV KHGVVNLSDG YTDKICYLAA NTAVIYDKRL RRQLFLQGHT
SPITCIVTTE DRSHVVTADT GPEALLVVWN VRTGLPTRTV QQPHRHGVST MDMSADGQWL
ATVSAADPES GEQEVSLWSM AALLTPPEAA PPGQGPLRPL VTTLVPAGDV QHSIRFSPNN
PAELISNGRR RVYFWSWAPG SPRFQYYSPP LRSRDFKQSV GDFVSSVFVP GTTQALTATT
DGDLVVWDEQ GIAAQVGTSA TDRRAIKLMR IHNCPITLLA TVGDFIVSGG EDGYVRFFDP
LLRIVAWFED LAAGPVTSVA FSAVLPDRLA HADAADTLNR FMVPDFVVAT RNSRIVSVQS
ASFEEYDADR RRGSSVLDSL LADVVDLAAH PTRAEFAVLG RDGGLQRWDS IAHCLLGGRA
FERQVGACLT YSRDGSLLVV GFGSGHLHIL NADDCSDLYV MRNTAAGLVR VAVSNTGKHI
AAADENHQLL LYAYLPYKHT MRWEYVGRCR SHHGPIASVV FGESPSGQTR LLSVGGDGRV
VEYDLAASSV AAGVQVASFY DFPPGGGAPT SLSFAPPLAY FQAFAADTHL LVSGADGTVA
SWDINTAPLE RSATAAEGAG GEARWAAVLG DPDLLREMRD YFVYAQIKTQ GEDALEPRDV
PGTVPVDLVP DLMRSAGFYP SESDIDNLLH HVQYMAHSRN MESLEVVTLA DLLCLYINHR
PLFNVTHADI VAAFRELGGR GDPGSCVPKL SREQLLSLLQ STGEPMSGEE LTAALAALTG
AHTPEKSMPV SVAAEQFSAD VLGFDTTEAG AEAAT
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