ID CC174_MOUSE Reviewed; 467 AA.
AC Q3U155; Q80XC8; Q8CA20;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 10-MAY-2017, entry version 64.
DE RecName: Full=Coiled-coil domain-containing protein 174;
GN Name=Ccdc174;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in neuronal development.
CC {ECO:0000250|UniProtKB:Q6PII3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PII3}.
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DR EMBL; AK039818; BAC30460.1; -; mRNA.
DR EMBL; AK156259; BAE33645.1; -; mRNA.
DR EMBL; BC051147; AAH51147.1; -; mRNA.
DR CCDS; CCDS20370.2; -.
DR RefSeq; NP_766318.2; NM_172730.2.
DR UniGene; Mm.234879; -.
DR iPTMnet; Q3U155; -.
DR PhosphoSitePlus; Q3U155; -.
DR EPD; Q3U155; -.
DR MaxQB; Q3U155; -.
DR PaxDb; Q3U155; -.
DR PeptideAtlas; Q3U155; -.
DR PRIDE; Q3U155; -.
DR GeneID; 232236; -.
DR KEGG; mmu:232236; -.
DR UCSC; uc009cyk.1; mouse.
DR CTD; 51244; -.
DR MGI; MGI:2444652; Ccdc174.
DR eggNOG; ENOG410IGB1; Eukaryota.
DR eggNOG; ENOG410Y526; LUCA.
DR HOGENOM; HOG000111357; -.
DR HOVERGEN; HBG055105; -.
DR InParanoid; Q3U155; -.
DR TreeFam; TF323679; -.
DR PRO; PR:Q3U155; -.
DR Proteomes; UP000000589; Unplaced.
DR Bgee; ENSMUSG00000034083; -.
DR CleanEx; MM_C130022K22RIK; -.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR025066; DUF4078.
DR Pfam; PF13300; DUF4078; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1 467 Coiled-coil domain-containing protein
FT 174.
FT /FTId=PRO_0000251957.
FT COILED 64 99 {ECO:0000255}.
FT COILED 268 310 {ECO:0000255}.
FT COMPBIAS 141 144 Poly-Asp.
FT COMPBIAS 220 225 Poly-Glu.
FT MOD_RES 198 198 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6PII3}.
FT CONFLICT 120 120 V -> D (in Ref. 2; AAH51147).
FT {ECO:0000305}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 215 303 ipfam:DUF4078 [T]
SQ SEQUENCE 467 AA; 53942 MW; 0C704AF154E68E8D CRC64;
MDRKKKPLDV TASSLVDLKA ELFRKQEEFK QEKLLKDSGV FGKPKTINKK PSIWSKQNAG
VTSRAEKDAE QKLEEQKTLD KAREKLEEKA KLYEKMTKGD FLDEEVEDMY LVDFTQKIIV
KRKEMEVLGA TRESQIEEER DDDDKEEFSD KDIPPPQDPS EEWVDYVDSL GRSRRCMRKD
LPSLLEMDKN LQGRLFVSPA NEKTLLSEDM RKELQRQQWE EEEREALKKP MGPIHYEDIR
ENEARQLGVG YFAFARDKEL RNKQMKTLEM LREQTTDQRI KRENIKEKRK AMLEARLAKL
RQKKMKKSKE DGTEEEGREA DGVVPEPSEP KPVPAPAPVA QNSKVEVIIQ ERRDTKPGVP
HIREWDRGKD FSFGFWSKKQ SELRAERDPE FAPPSNYFVG QKRTAPMSSQ PQSRPGSAPS
DLGHSSGQSQ EPSSSHTSTP ASESSPQAPT VTFQTLDDMI SYYKQVT
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