ID CC173_HUMAN Reviewed; 552 AA.
AC Q0VFZ6; Q6PJF6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 10-MAY-2017, entry version 77.
DE RecName: Full=Coiled-coil domain-containing protein 173;
GN Name=CCDC173; Synonyms=C2orf77;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17446.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR EMBL; AC016772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015980; AAH15980.1; -; mRNA.
DR EMBL; BC117445; AAI17446.1; ALT_INIT; mRNA.
DR CCDS; CCDS46445.1; -.
DR RefSeq; NP_001078916.1; NM_001085447.1.
DR UniGene; Hs.370111; -.
DR ProteinModelPortal; Q0VFZ6; -.
DR SMR; Q0VFZ6; -.
DR BioGrid; 126216; 4.
DR iPTMnet; Q0VFZ6; -.
DR PhosphoSitePlus; Q0VFZ6; -.
DR BioMuta; CCDC173; -.
DR DMDM; 327478499; -.
DR PaxDb; Q0VFZ6; -.
DR PeptideAtlas; Q0VFZ6; -.
DR PRIDE; Q0VFZ6; -.
DR DNASU; 129881; -.
DR Ensembl; ENST00000447353; ENSP00000391504; ENSG00000154479.
DR GeneID; 129881; -.
DR KEGG; hsa:129881; -.
DR UCSC; uc002ufe.3; human.
DR CTD; 129881; -.
DR GeneCards; CCDC173; -.
DR HGNC; HGNC:25064; CCDC173.
DR HPA; HPA042995; -.
DR HPA; HPA048454; -.
DR neXtProt; NX_Q0VFZ6; -.
DR OpenTargets; ENSG00000154479; -.
DR PharmGKB; PA162379577; -.
DR eggNOG; ENOG410IERG; Eukaryota.
DR eggNOG; ENOG410ZE2M; LUCA.
DR GeneTree; ENSGT00730000111149; -.
DR HOGENOM; HOG000006604; -.
DR HOVERGEN; HBG106646; -.
DR InParanoid; Q0VFZ6; -.
DR OMA; AKKEMHF; -.
DR OrthoDB; EOG091G0JME; -.
DR PhylomeDB; Q0VFZ6; -.
DR TreeFam; TF328736; -.
DR GenomeRNAi; 129881; -.
DR PRO; PR:Q0VFZ6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000154479; -.
DR CleanEx; HS_C2orf77; -.
DR ExpressionAtlas; Q0VFZ6; baseline and differential.
DR Genevisible; Q0VFZ6; HS.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Reference proteome.
FT CHAIN 1 552 Coiled-coil domain-containing protein
FT 173.
FT /FTId=PRO_0000318846.
FT COILED 53 143 {ECO:0000255}.
FT COILED 186 307 {ECO:0000255}.
FT COILED 348 409 {ECO:0000255}.
FT COILED 460 488 {ECO:0000255}.
SQ SEQUENCE 552 AA; 66403 MW; A727A02E40660938 CRC64;
MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII PHDEWKRIQD
SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM KEQKLEAKKK RDEEIEAERQ
ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE RVKNFHSGLL LSRVMKERDA QIEFRKSKIK
SDKKWEEQLK LNIEKAFKEE QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA
EEIKRQNALY EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR DIAEAEAEWE
KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK EQLLAVMKAD QIFWEHEKEK
KCKADKEHQE VQDAHIQQMA KNKFNAKQAK QAELDYCRLT EALVAEKEKE FQDYAREVIE
LESETTNKYI YPLVKAVQEG PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN
FQKSKRRLGF TW
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