ID CC103_MOUSE Reviewed; 237 AA.
AC Q9D9P2; A2AH86;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 10-MAY-2017, entry version 89.
DE RecName: Full=Coiled-coil domain-containing protein 103;
GN Name=Ccdc103;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Dynein-attachment factor required for cilia motility.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection,
CC cilium, flagellum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCDC103/PR46b family. {ECO:0000305}.
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DR EMBL; AK006639; BAB24684.1; -; mRNA.
DR EMBL; AK032002; BAC27644.1; -; mRNA.
DR EMBL; AL731670; CAM25114.1; -; Genomic_DNA.
DR EMBL; BC119102; AAI19103.1; -; mRNA.
DR EMBL; BC119104; AAI19105.1; -; mRNA.
DR CCDS; CCDS25506.1; -.
DR RefSeq; NP_082768.1; NM_028492.2.
DR UniGene; Mm.67659; -.
DR ProteinModelPortal; Q9D9P2; -.
DR PhosphoSitePlus; Q9D9P2; -.
DR PaxDb; Q9D9P2; -.
DR PRIDE; Q9D9P2; -.
DR Ensembl; ENSMUST00000021307; ENSMUSP00000021307; ENSMUSG00000020930.
DR GeneID; 73293; -.
DR KEGG; mmu:73293; -.
DR UCSC; uc007lst.1; mouse.
DR CTD; 388389; -.
DR MGI; MGI:1920543; Ccdc103.
DR eggNOG; ENOG410INY9; Eukaryota.
DR eggNOG; ENOG4111QAN; LUCA.
DR GeneTree; ENSGT00390000004038; -.
DR HOGENOM; HOG000231454; -.
DR HOVERGEN; HBG080287; -.
DR InParanoid; Q9D9P2; -.
DR OMA; EQRVASY; -.
DR OrthoDB; EOG091G123B; -.
DR PhylomeDB; Q9D9P2; -.
DR TreeFam; TF324467; -.
DR PRO; PR:Q9D9P2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000020930; -.
DR CleanEx; MM_CCDC103; -.
DR ExpressionAtlas; Q9D9P2; baseline and differential.
DR Genevisible; Q9D9P2; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISO:MGI.
DR GO; GO:0003341; P:cilium movement; ISO:MGI.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; ISO:MGI.
DR GO; GO:0001947; P:heart looping; ISO:MGI.
DR GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR GO; GO:0036158; P:outer dynein arm assembly; ISO:MGI.
DR InterPro; IPR031733; Dynein_attach_N.
DR InterPro; IPR025986; RPAP3-like_C.
DR Pfam; PF15867; Dynein_attach_N; 1.
DR Pfam; PF13877; RPAP3_C; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Complete proteome; Cytoplasm; Flagellum; Reference proteome.
FT CHAIN 1 237 Coiled-coil domain-containing protein
FT 103.
FT /FTId=PRO_0000263637.
FT COILED 8 33 {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 7 74 ipfam:Dynein_attach_N [T]
FT MYHIT 98 188 ipfam:RPAP3_C [T]
SQ SEQUENCE 237 AA; 26861 MW; 47F6875205715931 CRC64;
MEKNDVINFK ALEKELQAAL AADEKYKREN AAKLRAVEQR VPSYEEFRGI VLASHLKPLE
QKDKMGGKRF VPWNCHTTRE RTSQDVVTEI PQEKSPFQPT TSAEFYRDWR RHLRSGPERY
QALLQLGGPK LGHLFQMDVG FGLLGELLVA LAEHARLSDR TAVLGILHSL ANTGRFNLNL
SLLSHAERES CQRLFQKLQA MSTTRPMQEG LTVEEPSAGL QGEEGLLQEL LELYGVH
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