ID C9IZJ4_HUMAN Unreviewed; 287 AA.
AC C9IZJ4;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 10-MAY-2017, entry version 51.
DE SubName: Full=Zinc finger protein 561 {ECO:0000313|Ensembl:ENSP00000392013};
DE Flags: Fragment;
GN Name=ZNF561 {ECO:0000313|Ensembl:ENSP00000392013};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392013, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000392013, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000392013}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSP00000392013}.
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DR EMBL; AC008759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; C9IZJ4; -.
DR STRING; 9606.ENSP00000303915; -.
DR MaxQB; C9IZJ4; -.
DR PaxDb; C9IZJ4; -.
DR PeptideAtlas; C9IZJ4; -.
DR Ensembl; ENST00000444611; ENSP00000392013; ENSG00000171469.
DR UCSC; uc060tac.1; human.
DR HGNC; HGNC:28684; ZNF561.
DR OpenTargets; ENSG00000171469; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063830; -.
DR HOGENOM; HOG000234617; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000171469; -.
DR ExpressionAtlas; C9IZJ4; baseline and differential.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Metal-binding {ECO:0000256|SAAS:SAAS00780264};
KW Proteomics identification {ECO:0000213|MaxQB:C9IZJ4,
KW ECO:0000213|PeptideAtlas:C9IZJ4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|SAAS:SAAS00780289};
KW Zinc {ECO:0000256|SAAS:SAAS00780264};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00780264}.
FT DOMAIN 47 118 KRAB. {ECO:0000259|PROSITE:PS50805}.
FT DOMAIN 124 151 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 203 230 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 259 286 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT NON_TER 287 287 {ECO:0000313|Ensembl:ENSP00000392013}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 124 151 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 47 106 ismart:KRAB [T]
FT MYHIT 203 230 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 205 225 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 46 86 ipfam:KRAB [T]
FT MYHIT 203 225 ismart:ZnF_C2H2 [T]
FT MYHIT 124 144 ismart:ZnF_C2H2 [T]
FT MYHIT 47 118 iprf:KRAB [T]
FT MYHIT 259 286 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 287 AA; 32602 MW; AB5F7103934B3048 CRC64;
MHIITPSASE NGSHLFVPWE PICPFEEKTK VERMVEDYLA SGYQDSVTFD DVAVDFTPEE
WALLDTTEKY LYRDVMLENY MNLASVEWEI QPRTKRSSLQ QGFLKNQIFS GIQMTRGYSG
WKLCDCKNCG EVFREQFCLK THMRVQNGGN TSEGNCYGKD TLSVHKEAST GQELSKFNPC
GKVFTLTPGL AVHLEVLNAR QPYKCKECGK GFKYFASLDN HMGIHTDEKL CEFQEYGRAV
TASSHLKQCV AVHTGKKSKK TKKCGKSFTN FSQLYAPVKT HKGEKSF
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