Entry euk:BMT2_MOUSE

ID   BMT2_MOUSE              Reviewed;         403 AA.
AC   Q8BXK4; A6H608;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   10-MAY-2017, entry version 87.
DE   RecName: Full=Probable methyltransferase BMT2 homolog {ECO:0000255|HAMAP-Rule:MF_03044};
DE            EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_03044};
GN   Name=Bmt2 {ECO:0000312|MGI:MGI:2141466};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable S-adenosyl-L-methionine-dependent
CC       methyltransferase. {ECO:0000255|HAMAP-Rule:MF_03044}.
CC   -!- SIMILARITY: Belongs to the BMT2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03044}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC32852.1; Type=Frameshift; Positions=300; Evidence={ECO:0000305};
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DR   EMBL; AK046745; BAC32852.1; ALT_FRAME; mRNA.
DR   EMBL; BC145708; AAI45709.1; -; mRNA.
DR   EMBL; BC145710; AAI45711.1; -; mRNA.
DR   CCDS; CCDS51723.1; -.
DR   RefSeq; NP_780521.2; NM_175312.4.
DR   UniGene; Mm.354863; -.
DR   ProteinModelPortal; Q8BXK4; -.
DR   STRING; 10090.ENSMUSP00000040578; -.
DR   iPTMnet; Q8BXK4; -.
DR   PhosphoSitePlus; Q8BXK4; -.
DR   MaxQB; Q8BXK4; -.
DR   PaxDb; Q8BXK4; -.
DR   PeptideAtlas; Q8BXK4; -.
DR   PRIDE; Q8BXK4; -.
DR   Ensembl; ENSMUST00000045235; ENSMUSP00000040578; ENSMUSG00000042742.
DR   GeneID; 101148; -.
DR   KEGG; mmu:101148; -.
DR   UCSC; uc012eic.1; mouse.
DR   CTD; 154743; -.
DR   MGI; MGI:2141466; Bmt2.
DR   eggNOG; ENOG410IH2N; Eukaryota.
DR   eggNOG; ENOG410XT5Y; LUCA.
DR   GeneTree; ENSGT00390000010382; -.
DR   HOVERGEN; HBG054033; -.
DR   InParanoid; Q8BXK4; -.
DR   OMA; MAFRKTS; -.
DR   OrthoDB; EOG091G08HR; -.
DR   PhylomeDB; Q8BXK4; -.
DR   TreeFam; TF324724; -.
DR   PRO; PR:Q8BXK4; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000042742; -.
DR   CleanEx; MM_B630005N14RIK; -.
DR   ExpressionAtlas; Q8BXK4; baseline and differential.
DR   Genevisible; Q8BXK4; MM.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0016433; F:rRNA (adenine) methyltransferase activity; IBA:GO_Central.
DR   HAMAP; MF_03044; BMT2; 1.
DR   InterPro; IPR021867; Bmt2.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   PANTHER; PTHR21008; PTHR21008; 1.
DR   Pfam; PF11968; Bmt2; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    403       Probable methyltransferase BMT2 homolog.
FT                                /FTId=PRO_0000321540.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       225    321       ipfam:Bmt2 [T]
FT   MYHIT        27    348       ihamap:BMT2 [T]
SQ   SEQUENCE   403 AA;  45952 MW;  2ECD73F0623FB4CF CRC64;
     MEPGPGGRGA ARGQRPPNAA QPREQERKLE QEKLSGVVKS VHRRLRKKYR EVGDFDKIWR
     EHCEDAETLC EYAVAMKNLA DNHWAKTCEG EGRIEWCCSV CREYFQNGGK RKALEKDEKR
     AVLATKTTPA LNVHESSKLE GPLTNLSFTS PDFITELLQA SGKIRLLDVG SCFNPFLKFE
     EFLTVGIDIV PAVESVYKCD FLNLQLQQPL QLAQDAIDAF LKQLRNPIDA LPGELFHVVV
     FSLLLSYFPS PYQRWICCKK AHELLVLNGL LLIITPDSSH QNRHAMMMKS WKIAIESLGF
     KRFKYSKFSH MHLMAFRKTS LKTTSDLVSR NYPGMLYIPQ DFNSVEEEEY SNTSCYVRSD
     LEDEQLAYGF TELPEAPYDS DSGESQASSI PFYELEDPIL LLS
//