ID BH115_ARATH Reviewed; 226 AA.
AC Q9C682;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 10-MAY-2017, entry version 102.
DE RecName: Full=Transcription factor bHLH115;
DE AltName: Full=Basic helix-loop-helix protein 115;
DE Short=AtbHLH115;
DE Short=bHLH 115;
DE AltName: Full=Transcription factor EN 134;
DE AltName: Full=bHLH transcription factor bHLH115;
GN Name=BHLH115; Synonyms=EN134; OrderedLocusNames=At1g51070;
GN ORFNames=F23H24.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Portal (Araport);
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E.,
RA Heim M.A., Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family
RT in Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [8]
RP INTERACTION WITH BTS.
RC STRAIN=cv. Columbia;
RX PubMed=20675571; DOI=10.1105/tpc.110.074096;
RA Long T.A., Tsukagoshi H., Busch W., Lahner B., Salt D.E., Benfey P.N.;
RT "The bHLH transcription factor POPEYE regulates response to iron
RT deficiency in Arabidopsis roots.";
RL Plant Cell 22:2219-2236(2010).
RN [9]
RP INTERACTION WITH BTS AND BHLH47/PYE, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=25452667; DOI=10.1104/pp.114.250837;
RA Selote D., Samira R., Matthiadis A., Gillikin J.W., Long T.A.;
RT "Iron-binding E3 ligase mediates iron response in plants by targeting
RT basic helix-loop-helix transcription factors.";
RL Plant Physiol. 167:273-286(2015).
CC -!- SUBUNIT: Homodimer (Probable). Interacts with BTS and BHLH47/PYE
CC (PubMed:20675571, PubMed:25452667). {ECO:0000269|PubMed:20675571,
CC ECO:0000269|PubMed:25452667, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC ProRule:PRU00981, ECO:0000269|PubMed:25452667}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9C682-1; Sequence=Displayed;
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DR EMBL; AF488632; AAM10965.1; -; mRNA.
DR EMBL; AC079828; AAG50538.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32618.1; -; Genomic_DNA.
DR EMBL; BT002433; AAO00793.1; -; mRNA.
DR EMBL; BT006273; AAP13381.1; -; mRNA.
DR EMBL; AY085619; AAM62840.1; -; mRNA.
DR PIR; H96547; H96547.
DR RefSeq; NP_175518.1; NM_103985.4. [Q9C682-1]
DR UniGene; At.17182; -.
DR UniGene; At.37898; -.
DR ProteinModelPortal; Q9C682; -.
DR BioGrid; 26754; 3.
DR EnsemblPlants; AT1G51070.1; AT1G51070.1; AT1G51070. [Q9C682-1]
DR GeneID; 841529; -.
DR Gramene; AT1G51070.1; AT1G51070.1; AT1G51070.
DR KEGG; ath:AT1G51070; -.
DR Araport; AT1G51070; -.
DR HOGENOM; HOG000238732; -.
DR InParanoid; Q9C682; -.
DR PhylomeDB; Q9C682; -.
DR PRO; PR:Q9C682; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C682; baseline and differential.
DR Genevisible; Q9C682; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd00083; HLH; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1 226 Transcription factor bHLH115.
FT /FTId=PRO_0000358801.
FT DOMAIN 66 117 bHLH. {ECO:0000255|PROSITE-
FT ProRule:PRU00981}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 66 117 iprf:BHLH [T]
FT MYHIT 70 116 ipfam:HLH [T]
FT MYHIT 72 123 ismart:HLH [T]
SQ SEQUENCE 226 AA; 25512 MW; 6C0024AD23DE48A9 CRC64;
MVSPENTNWL SDYPLIEGAF SDQNPTFPWQ IDGSATVSVE VDGFLCDADV IKEPSSRKRI
KTESCTGSNS KACREKQRRD RLNDKFTELS SVLEPGRTPK TDKVAIINDA IRMVNQARDE
AQKLKDLNSS LQEKIKELKD EKNELRDEKQ KLKVEKERID QQLKAIKTQP QPQPCFLPNP
QTLSQAQAPG SKLVPFTTYP GFAMWQFMPP AAVDTSQDHV LRPPVA
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