MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
Description | RecName: Full=Transcription factor bHLH100; AltName: Full=Basic helix-loop-helix protein 100; Short=AtbHLH100; Short=bHLH 100; AltName: Full=Transcription factor EN 7; AltName: Full=bHLH transcription factor bHLH100; |
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MyHits synonyms | BH100_ARATH , Q9ZVB5 , Q3E7M6 , 2E3FDE4D3653C1E3 |
![]() Legends: 1, VAR_SEQ Missing (in isoform 2). {ECO:0000303|PubMed:12679534}; 2, CONFLICT Q -> R (in Ref. 4; AF488626). {ECO:0000305}; 3, bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981}.
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ID BH100_ARATH Reviewed; 242 AA. AC Q9ZVB5; Q3E7M6; DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 10-MAY-2017, entry version 103. DE RecName: Full=Transcription factor bHLH100; DE AltName: Full=Basic helix-loop-helix protein 100; DE Short=AtbHLH100; DE Short=bHLH 100; DE AltName: Full=Transcription factor EN 7; DE AltName: Full=bHLH transcription factor bHLH100; GN Name=BHLH100; Synonyms=EN7; OrderedLocusNames=At2g41240; GN ORFNames=F13H10.21; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 17-242 (ISOFORM 2), TISSUE SPECIFICITY, RP INDUCTION, GENE FAMILY, AND NOMENCLATURE. RC STRAIN=cv. Columbia; RX PubMed=12679534; DOI=10.1093/molbev/msg088; RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.; RT "The basic helix-loop-helix transcription factor family in plants: a RT genome-wide study of protein structure and functional diversity."; RL Mol. Biol. Evol. 20:735-747(2003). RN [5] RP GENE FAMILY. RX PubMed=12897250; DOI=10.1105/tpc.013839; RA Toledo-Ortiz G., Huq E., Quail P.H.; RT "The Arabidopsis basic/helix-loop-helix transcription factor family."; RL Plant Cell 15:1749-1770(2003). RN [6] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=14600211; DOI=10.1105/tpc.151140; RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., RA Heim M.A., Jakoby M., Werber M., Weisshaar B.; RT "Update on the basic helix-loop-helix transcription factor gene family RT in Arabidopsis thaliana."; RL Plant Cell 15:2497-2502(2003). RN [7] RP INDUCTION. RX PubMed=17516080; DOI=10.1007/s00425-007-0535-x; RA Wang H.-Y., Klatte M., Jakoby M., Baeumlein H., Weisshaar B., RA Bauer P.; RT "Iron deficiency-mediated stress regulation of four subgroup Ib BHLH RT genes in Arabidopsis thaliana."; RL Planta 226:897-908(2007). RN [8] RP FUNCTION, AND INDUCTION. RX PubMed=18088336; DOI=10.1111/j.1365-3040.2007.01764.x; RA van de Mortel J.E., Schat H., Moerland P.D., Ver Loren van Themaat E., RA van der Ent S., Blankestijn H., Ghandilyan A., Tsiatsiani S., RA Aarts M.G.M.; RT "Expression differences for genes involved in lignin, glutathione and RT sulphate metabolism in response to cadmium in Arabidopsis thaliana and RT the related Zn/Cd-hyperaccumulator Thlaspi caerulescens."; RL Plant Cell Environ. 31:301-324(2008). CC -!- FUNCTION: Plays a role in metal homeostasis. Confers tolerance to CC high zinc (Zn) and nickel (Ni). {ECO:0000269|PubMed:18088336}. CC -!- SUBUNIT: Homodimer. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE- CC ProRule:PRU00981}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9ZVB5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9ZVB5-2; Sequence=VSP_036095; CC Note=May be due to a competing acceptor splice site. No CC experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, and CC stems. {ECO:0000269|PubMed:12679534}. CC -!- INDUCTION: Up regulated by iron deficiency in roots and leaves, as CC well as by nickel, high zinc or high copper treatments. Repressed CC by heat treatment, high iron, low copper and low zinc treatments. CC {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17516080, CC ECO:0000269|PubMed:18088336}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AC005662; AAC78547.1; -; Genomic_DNA. DR EMBL; CP002685; AEC09951.1; -; Genomic_DNA. DR EMBL; CP002685; AEC09952.1; -; Genomic_DNA. DR EMBL; AY074635; AAL69451.1; -; mRNA. DR EMBL; AF488626; -; NOT_ANNOTATED_CDS; mRNA. DR PIR; E84839; E84839. DR RefSeq; NP_181657.1; NM_129689.2. [Q9ZVB5-1] DR RefSeq; NP_850349.1; NM_180018.1. [Q9ZVB5-2] DR UniGene; At.37027; -. DR ProteinModelPortal; Q9ZVB5; -. DR BioGrid; 4060; 1. DR STRING; 3702.AT2G41240.1; -. DR PaxDb; Q9ZVB5; -. DR EnsemblPlants; AT2G41240.1; AT2G41240.1; AT2G41240. [Q9ZVB5-1] DR GeneID; 818723; -. DR Gramene; AT2G41240.1; AT2G41240.1; AT2G41240. DR KEGG; ath:AT2G41240; -. DR Araport; AT2G41240; -. DR TAIR; locus:2040287; AT2G41240. DR eggNOG; ENOG410IY4E; Eukaryota. DR eggNOG; ENOG410YP85; LUCA. DR HOGENOM; HOG000238662; -. DR InParanoid; Q9ZVB5; -. DR OMA; CASQLSN; -. DR OrthoDB; EOG09360NDZ; -. DR PhylomeDB; Q9ZVB5; -. DR PRO; PR:Q9ZVB5; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q9ZVB5; baseline and differential. DR GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:TAIR. DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:TAIR. DR GO; GO:0055072; P:iron ion homeostasis; IGI:TAIR. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR. DR GO; GO:0009414; P:response to water deprivation; IEP:TAIR. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR CDD; cd00083; HLH; 1. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR015660; Achaete-scute-rel. DR InterPro; IPR011598; bHLH_dom. DR PANTHER; PTHR13935; PTHR13935; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; DNA-binding; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1 242 Transcription factor bHLH100. FT /FTId=PRO_0000358789. FT DOMAIN 61 113 bHLH. {ECO:0000255|PROSITE- FT ProRule:PRU00981}. FT VAR_SEQ 96 96 Missing (in isoform 2). FT {ECO:0000303|PubMed:12679534}. FT /FTId=VSP_036095. FT CONFLICT 215 215 Q -> R (in Ref. 4; AF488626). FT {ECO:0000305}. CC -------------------------------------------------------------------------- CC The following FT lines are automated annotations from the MyHits database. CC -------------------------------------------------------------------------- FT MYHIT 62 114 ipfam:HLH [T] FT MYHIT 61 113 iprf:BHLH [T] FT MYHIT 67 119 ismart:HLH [T] SQ SEQUENCE 242 AA; 27217 MW; 2E3FDE4D3653C1E3 CRC64; MCALVPPLYP NFGWPCGDHS FYETDDVSNT FLDFPLPDLT VTHENVSSEN NRTLLDNPVV MKKLNHNASE RERRKKINTM FSSLRSCLPP TNQTKKLSVS ATVSQALKYI PELQEQVKKL MKKKEELSFQ ISGQRDLVYT DQNSKSEEGV TSYASTVSST RLSETEVMVQ ISSLQTEKCS FGNVLSGVEE DGLVLVGASS SRSHGERLFY SMHLQIKNGQ VNSEELGDRL LYLYEKCGHS FT // |