Entry euk:B8JLN4_DANRE

ID   B8JLN4_DANRE            Unreviewed;       429 AA.
AC   B8JLN4;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   10-MAY-2017, entry version 70.
DE   SubName: Full=E2F transcription factor 3 {ECO:0000313|Ensembl:ENSDARP00000109781};
GN   Name=e2f3 {ECO:0000313|Ensembl:ENSDARP00000109781,
GN   ECO:0000313|ZFIN:ZDB-GENE-070112-882};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000109781, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000109781, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109781,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000109781}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109781};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|RuleBase:RU003796}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000109781}.
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DR   EMBL; CU469458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001074097.2; NM_001080628.2.
DR   UniGene; Dr.76098; -.
DR   STRING; 7955.ENSDARP00000109781; -.
DR   PaxDb; B8JLN4; -.
DR   PeptideAtlas; B8JLN4; -.
DR   Ensembl; ENSDART00000130815; ENSDARP00000109781; ENSDARG00000070463.
DR   GeneID; 791146; -.
DR   KEGG; dre:791146; -.
DR   CTD; 1871; -.
DR   ZFIN; ZDB-GENE-070112-882; e2f3.
DR   eggNOG; KOG2577; Eukaryota.
DR   eggNOG; ENOG410XNYI; LUCA.
DR   GeneTree; ENSGT00550000074403; -.
DR   HOGENOM; HOG000232045; -.
DR   HOVERGEN; HBG002227; -.
DR   InParanoid; B8JLN4; -.
DR   KO; K06620; -.
DR   PhylomeDB; B8JLN4; -.
DR   TreeFam; TF105566; -.
DR   Reactome; R-DRE-68689; CDC6 association with the ORC:origin complex.
DR   Reactome; R-DRE-68911; G2 Phase.
DR   Reactome; R-DRE-69231; Cyclin D associated events in G1.
DR   Reactome; R-DRE-69298; Association of licensing factors with the pre-replicative complex.
DR   Proteomes; UP000000437; Chromosome 19.
DR   Bgee; ENSDARG00000070463; -.
DR   ExpressionAtlas; B8JLN4; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd14660; E2F_DD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR032198; E2F_CC-MB.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR12081; PTHR12081; 1.
DR   Pfam; PF16421; E2F_CC-MB; 1.
DR   Pfam; PF02319; E2F_TDP; 1.
DR   SMART; SM01372; E2F_TDP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   DNA-binding {ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transcription {ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN      130    195       E2F_TDP. {ECO:0000259|SMART:SM01372}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       130    195       ismart:E2F_TDP [T]
FT   MYHIT       215    306       ipfam:E2F_CC-MB [T]
FT   MYHIT       132    195       ipfam:E2F_TDP [T]
SQ   SEQUENCE   429 AA;  46471 MW;  1E13E890CB137584 CRC64;
     MRKGGSSVPG QVMLTGVVRA EQHGVFTAVS DRRCAVYSNA TRIQINTPPS TNNGCVPEAS
     ADSLYTTPLQ GSTHGTGLRP TLGRPPAKRR LELDITDHQY SEPAKTLRSR KGALKLKIPK
     APKTPPEKTR YDTSLGFLTK KFCQLLAQSS DGVLDLNKAA IVLNVQKRRL YDITNVLEGV
     RLIKKKSKNN IQWLGSSLPS DGGLPSPAMQ SHSLAREMLA LTQEERRLDE LIQTCTRNVQ
     QMTEEIHSQK YAYVTYQDIR RIKSLKDQTV IAIKAPSETK LEVPDPKESL QVHLSSSKGP
     IDVFLCTDGG DSGSPLQNGL DVNGNHPAFL KVSQEAASDG PADNVKMNGN SNASVNGFGP
     VSGNAPMSPL SSSLSSILQQ PEEAIPFVPL SPALLSDEYM LGLGDEQGIS DLFDSCDLDT
     LALDDLLRI
//