Entry euk:B7ZVK0_DANRE

ID   B7ZVK0_DANRE            Unreviewed;      1459 AA.
AC   B7ZVK0;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   10-MAY-2017, entry version 71.
DE   SubName: Full=Zgc:171445 {ECO:0000313|Ensembl:ENSDARP00000046453};
DE   SubName: Full=Zgc:171445 protein {ECO:0000313|EMBL:AAI71612.1};
GN   ORFNames=zgc:171445 {ECO:0000313|EMBL:AAI71612.1,
GN   ECO:0000313|Ensembl:ENSDARP00000046453,
GN   ECO:0000313|ZFIN:ZDB-GENE-080205-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI71612.1};
RN   [1] {ECO:0000313|EMBL:AAI71612.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000046453}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046453};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000046453, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046453,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; BX322654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC171612; AAI71612.1; -; mRNA.
DR   UniGene; Dr.162016; -.
DR   STRING; 7955.ENSDARP00000046453; -.
DR   Ensembl; ENSDART00000046454; ENSDARP00000046453; ENSDARG00000076771.
DR   ZFIN; ZDB-GENE-080205-2; zgc:171445.
DR   eggNOG; ENOG410KCRJ; Eukaryota.
DR   eggNOG; COG2373; LUCA.
DR   GeneTree; ENSGT00760000118982; -.
DR   HOVERGEN; HBG000039; -.
DR   TreeFam; TF313285; -.
DR   Proteomes; UP000000437; Chromosome 3.
DR   Bgee; ENSDARG00000076771; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 2.60.40.690; -; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR011626; A2M_comp.
DR   InterPro; IPR002890; A2M_N.
DR   InterPro; IPR011625; A2M_N_2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07678; A2M_comp; 1.
DR   Pfam; PF01835; A2M_N; 1.
DR   Pfam; PF07703; A2M_N_2; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF10569; Thiol-ester_cl; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   SUPFAM; SSF49410; SSF49410; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B7ZVK0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1459       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010108672.
FT   DOMAIN      479    627       A2M_N_2. {ECO:0000259|SMART:SM01359}.
FT   DOMAIN      753    842       A2M. {ECO:0000259|SMART:SM01360}.
FT   DOMAIN     1365   1454       A2M_recep. {ECO:0000259|SMART:SM01361}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       753    841       ipfam:A2M [T]
FT   MYHIT      1365   1454       ipfam:A2M_recep [T]
FT   MYHIT       480    627       ipfam:A2M_N_2 [T]
FT   MYHIT       479    627       ismart:A2M_N_2 [T]
FT   MYHIT      1365   1454       ismart:A2M_recep [T]
FT   MYHIT       974   1003       ipfam:Thiol-ester_cl [T]
FT   MYHIT      1023   1255       ipfam:A2M_comp [T]
FT   MYHIT       753    842       ismart:A2M [T]
FT   MYHIT       982    990       ipat:ALPHA_2_MACROGLOBULIN [T]
FT   MYHIT       146    237       ipfam:A2M_N [T]
SQ   SEQUENCE   1459 AA;  158709 MW;  2144C4853F547C7A CRC64;
     MAMMEISVWK WINLVLFFCF VDGAKLIVEA PKPIETLVTA DEQISGPLFL VTFPSLIESG
     SGAKLCASLL KPQGSLTITI TLIDDKSAET RLVRQTTQRK LHRCFNFQAP LVNGDSVQTV
     RVVVQGQSFK MTEERKVMFR SYLPLTFIQT DKPLYNPGQT VNFRVVTMSD KFVPLDQMYN
     LVVLEDFRNI RINQWTNVSS VNWILELSHV LIPEAQVGTY TLRAYIGDRI ISQSFDVKQY
     VLPKFDVTVN TLQMYSVADA GLKVEACGKY TFGQPVPGQV LVQVCRQPLA FIQDTKVTSI
     CLNKSMRTNN TGCASLTLST SSFFGTSSES NLQNSFVVNV NLTEEGTGVV MSKSTTVSIT
     FEVGKVTFVD LPKFYNYGST VNGKISVSDF NGNPIYSKAV YLLDSSIWPN KLLFNLTTNQ
     NGFAKFSLDT TSFPQADLNL VASATPQSYF SSNSPYFTTD SQVVQLSQTD PDTPTFSDLS
     IVKLEQPLKC GTTYSVTVKY LFVGETGDYS ADIIYMVMSR GVIVLHGFKT VQARASNTLT
     KGTVTFDLSV LAKMAPMVQI LVYSVLPSQT VVTGSASFDT EKCFSNQVSL QFSPATAVPG
     EGNILTVSAQ AGSLCGLSAI DQSVLIMQSG GRLSAEAVFN MLPLQSLSDY PYGAEDQQDC
     LNVRPRRAVP TDQAYNAFKS VGMKIATNLP VREPECLKFK DLLYYRNFHG VFPFRGTGFA
     MAEMAPAPLA TAEIGGTRGS SVDVTIRTYF PETWIWQLAL VGDSGSTSVP LTVPDTITTW
     DTEAFCLSSN GFGLAPPALL TSFQPFFLEL TLPYSIIRGE AFELVATVFN YLLQCLKIQV
     TPTPSSNYTL TPINDQSSST LSTNWRKTIK WALTASVIGT VNVTISAEAS PSQELCGDQD
     VTVLSRGRID IVTRSLRVLA EGVERTFTRS WLLCPKGSVL SESVKITLPT NVIQGSASCS
     VSVIGDIMGR ALNNLANLLQ MPSGCGEQNM IILAPNVYIL RYLTVTAQLT PAVQDTATSY
     LLTGYQGELN YRHSDGSFST FGYDASNTWL TAFVMRTFGL ARSFTYIDPN VLKGAKDWLI
     STQGSDGCFV QQGTLYHNDM KGGVGDNVTM TGYIVASLLE IGVPATDPVI MKALSFLRPL
     VGNLGNTYVT ALLAYTFSLA GETSTRAQLL NSLRNTAISE GTTLHWSQTT SGDTLAVEIS
     AYVLLAVLTV QPVTTANLGY ANRIVNWIVA QQNPYGGFSS TQDTVVALQA LALYAAQAFT
     PGGSSTVTVQ SSVPAGDIFN FAVTPNNRLL YQRNSLNNFP GTYSVVARGS ACASVQVACF
     YNVPTPVTVA KTLSVVAKVT GDCQAAPVNL MLTFTVKYNG RKPATNMVLV DIKVLSGFTA
     DTSLLGSPPN FAPLVQRVDS NGDHVLVYLQ EVPKGVPVTF SIQLTQTVAV QNLKPAVINI
     YDYYQRSDKF ETTYKSPCP
//