Entry euk:B3DJ81_DANRE

ID   B3DJ81_DANRE            Unreviewed;       408 AA.
AC   B3DJ81;
DT   22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 1.
DT   10-MAY-2017, entry version 74.
DE   SubName: Full=Relaxin/insulin-like family peptide receptor 3 {ECO:0000313|Ensembl:ENSDARP00000074526};
DE   SubName: Full=Similar to G protein-coupled receptor 100 {ECO:0000313|EMBL:AAI63390.1};
GN   Name=rxfp3 {ECO:0000313|Ensembl:ENSDARP00000074526,
GN   ECO:0000313|ZFIN:ZDB-GENE-080723-67};
GN   Synonyms=LOC794924 {ECO:0000313|EMBL:AAI63390.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63390.1};
RN   [1] {ECO:0000313|EMBL:AAI63390.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000074526}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074526};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000074526, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074526,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; CR749169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC163390; AAI63390.1; -; mRNA.
DR   EMBL; BC163404; AAI63404.1; -; mRNA.
DR   RefSeq; NP_001122260.1; NM_001128788.2.
DR   UniGene; Dr.103921; -.
DR   STRING; 7955.ENSDARP00000074526; -.
DR   Ensembl; ENSDART00000080076; ENSDARP00000074526; ENSDARG00000057410.
DR   GeneID; 794924; -.
DR   KEGG; dre:794924; -.
DR   CTD; 51289; -.
DR   ZFIN; ZDB-GENE-080723-67; rxfp3.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   GeneTree; ENSGT00760000119055; -.
DR   HOGENOM; HOG000230485; -.
DR   HOVERGEN; HBG101327; -.
DR   KO; K08397; -.
DR   OMA; WVVCALG; -.
DR   OrthoDB; EOG091G0BQS; -.
DR   TreeFam; TF330024; -.
DR   Reactome; R-DRE-418594; G alpha (i) signalling events.
DR   Reactome; R-DRE-444821; Relaxin receptors.
DR   Proteomes; UP000000437; Chromosome 21.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004966; F:galanin receptor activity; IBA:GO_Central.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AAI63390.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     53     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    174    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    230    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    272    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    336       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       73    333       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        73    333       iprf:G_PROTEIN_RECEP_F1_2 [T]
FT   MYHIT        73    333       ipfam:7tm_1 [T]
SQ   SEQUENCE   408 AA;  45881 MW;  38ACEB682FD79FB3 CRC64;
     MEKTSDIERA EYASGSLPLT EYNASFTVNR TNLSWTDFQD LGDKPDFMGD GSAVLRIIIS
     IIYSVVCALG LIGNILVLYL MKSKQAWKKS SINLFVTSLA VTDFQFVLTL PFWAVENAMD
     FTWLFGKAMC KIVSYVTATN MYASVFFLTA MSVARYCSVA SALKSKRRRL RFSAQWMTVI
     IWIAAVGAAL PNAIFSTTAT VSNEELCLVK FPDRSGDAQF WLGLYHAQKV LLGFLIPFGI
     ISICYLLLLR FITNKNINTS SAKRRSKVTR SVTIVVLSFF LCWLPNQALT AWGILIKLNV
     VHFSYEYYTT QVYIFPVTVC LAHSNSCLNP ILYCLMRREF RKALKKLFWQ ITSPSVTNMR
     PFTASTKPEQ DEQAPALIPL SPAEPALVFY PPGVVIYNGR NDLLPNST
//