ID B3DHC5_DANRE Unreviewed; 255 AA.
AC B3DHC5;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 10-MAY-2017, entry version 74.
DE SubName: Full=Apolipoprotein A-IV b, tandem duplicate 2 {ECO:0000313|Ensembl:ENSDARP00000093966};
DE SubName: Full=Zgc:194131 {ECO:0000313|EMBL:AAI62715.1};
GN Name=apoa4b.2 {ECO:0000313|Ensembl:ENSDARP00000093966,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-3143};
GN ORFNames=zgc:194131 {ECO:0000313|EMBL:AAI62715.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62715.1};
RN [1] {ECO:0000313|EMBL:AAI62715.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000093966}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000093966, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000093966,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00412673}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|SAAS:SAAS00598075}.
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DR EMBL; BX004983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162715; AAI62715.1; -; mRNA.
DR EMBL; BC162716; AAI62716.1; -; mRNA.
DR RefSeq; NP_001122230.1; NM_001128758.1.
DR UniGene; Dr.159496; -.
DR STRING; 7955.ENSDARP00000093966; -.
DR Ensembl; ENSDART00000103190; ENSDARP00000093966; ENSDARG00000020866.
DR Ensembl; ENSDART00000142168; ENSDARP00000114649; ENSDARG00000020866.
DR GeneID; 570354; -.
DR KEGG; dre:570354; -.
DR CTD; 570354; -.
DR ZFIN; ZDB-GENE-030131-3143; apoa4b.2.
DR eggNOG; ENOG410IKU1; Eukaryota.
DR eggNOG; ENOG41119VI; LUCA.
DR GeneTree; ENSGT00530000063081; -.
DR HOGENOM; HOG000063678; -.
DR HOVERGEN; HBG107479; -.
DR OMA; QSQLGPY; -.
DR TreeFam; TF334458; -.
DR Reactome; R-DRE-174800; Chylomicron-mediated lipid transport.
DR Reactome; R-DRE-975634; Retinoid metabolism and transport.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000020866; -.
DR GO; GO:0072562; C:blood microparticle; IBA:GO_Central.
DR GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0017127; F:cholesterol transporter activity; IBA:GO_Central.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IBA:GO_Central.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
DR GO; GO:0042157; P:lipoprotein metabolic process; IBA:GO_Central.
DR GO; GO:0031102; P:neuron projection regeneration; IBA:GO_Central.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central.
DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
DR GO; GO:0010873; P:positive regulation of cholesterol esterification; IBA:GO_Central.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central.
DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central.
DR GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central.
DR GO; GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
DR InterPro; IPR000074; ApoA_E.
DR Pfam; PF01442; Apolipoprotein; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Lipid transport {ECO:0000256|SAAS:SAAS00491985};
KW Proteomics identification {ECO:0000213|PeptideAtlas:B3DHC5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|SAAS:SAAS00491987};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|SAAS:SAAS00491985}.
FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
FT CHAIN 18 255 {ECO:0000256|SAM:SignalP}.
FT /FTId=PRO_5010105134.
FT COILED 153 177 {ECO:0000256|SAM:Coils}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 66 250 ipfam:Apolipoprotein [T]
SQ SEQUENCE 255 AA; 29384 MW; 94E4385541269D82 CRC64;
MKVLVVFALA VFTGCQANLF YADEPKPQLE QLTDAFWSYV SKATQTAEET VKMIRESQLG
QEVNERLTQS ADMASEYAVV LKKQVDPLTE ELMNKITKET EVLRERLGQD LINVREKLEP
YADNMKSQIQ QRVEELRAAM APYADSLDSE TLKATLLQKS EELRGNLEQS VKELQVQLEP
YTAELKEKVD QHLQEFQKTV TPLTEDLQVQ IRERAQMVQQ SLTPYAEDLK EKLDPYAQNL
KDQLASLYES YTKRN
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