Entry euk:B2RR19_MOUSE

ID   B2RR19_MOUSE            Unreviewed;       549 AA.
AC   B2RR19;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   10-MAY-2017, entry version 69.
DE   SubName: Full=Cilia- and flagella-associated protein 251 {ECO:0000313|Ensembl:ENSMUSP00000129769};
DE   SubName: Full=Wdr66 protein {ECO:0000313|EMBL:AAI38177.1};
GN   Name=Wdr66 {ECO:0000313|EMBL:AAI38177.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000129769, ECO:0000313|MGI:MGI:1918495};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI38177.1};
RN   [1] {ECO:0000313|EMBL:AAI38177.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI38177.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000129769, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129769,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000129769}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129769};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC113504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC163337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC138176; AAI38177.1; -; mRNA.
DR   UniGene; Mm.444012; -.
DR   STRING; 10090.ENSMUSP00000113309; -.
DR   Ensembl; ENSMUST00000170536; ENSMUSP00000129769; ENSMUSG00000029442.
DR   UCSC; uc008znl.1; mouse.
DR   MGI; MGI:1918495; Wdr66.
DR   eggNOG; ENOG410JR21; Eukaryota.
DR   eggNOG; ENOG410XQRH; LUCA.
DR   GeneTree; ENSGT00390000013370; -.
DR   HOGENOM; HOG000067979; -.
DR   HOVERGEN; HBG068255; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000029442; -.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Proteomics identification {ECO:0000213|MaxQB:B2RR19};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN      313    441       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       306    345       ismart:WD40 [T]
FT   MYHIT       320    345       ipfam:WD40 [T]
FT   MYHIT       393    432       ismart:WD40 [T]
FT   MYHIT       441    484       ismart:WD40 [T]
FT   MYHIT       204    238       ismart:WD40 [T]
FT   MYHIT       313    441       iprf:WD_REPEATS_REGION [T]
FT   MYHIT       350    388       ismart:WD40 [T]
FT   MYHIT        42     86       ismart:WD40 [T]
SQ   SEQUENCE   549 AA;  61655 MW;  AE6E955A4FEDCDC1 CRC64;
     MGHKYSVAQT DHSVGLAGFS LPGKPGIPLQ GPPLSVRFFF FFRIPVHTIF DSCPEGNGMR
     SIAITRDSKF LATISDSATQ KVCIWKWTLA VETPACTLEL PKEYGFQDNL VFNPANNKEL
     VSNSKTQAIY YCWFEDKGIL AHSAPVLTEK TFNKLVGKFS QSVFHLKLPQ VLSATKEGKL
     VVWDIHYPSS TSSSAISAFP FIKPRKLVHL QKEAITVLMT IDSYIVTGDI KGNIKFYDHT
     LSVVNWYSNF KLGAIRTLSF SKTIPSLPTE KSNLPTDCTL RGDLFVVRNF IIGTFDATVY
     HMTVDGTKLE KLFVEPRDAV YAVSCHPYQP LIAVGSVCGM IKVWDFEKKV YLFSRTFEKG
     LGVQCLTYNP EGALLGAGFT EGTVYILDAM SLENESPEPF KYSKSSVSHC CFSHDSNYMA
     TADVNFTVAV YMVVVKNGQR VWEYLARLRS HQNSIQSLLF GVHLDSNEPR LLSLGKDRFL
     IEYNLVKSCK DHLDVLDVHR TDQGNYPTCM IWYPPLTKEL FLLICNSGYK VKLFNATTKM
     CRSCLSICI
//