Entry euk:B1H1M0_DANRE

ID   B1H1M0_DANRE            Unreviewed;       664 AA.
AC   B1H1M0;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   10-MAY-2017, entry version 78.
DE   SubName: Full=Ring finger protein 139 {ECO:0000313|Ensembl:ENSDARP00000053621};
DE   SubName: Full=Zgc:175173 protein {ECO:0000313|EMBL:AAI60659.1};
GN   Name=rnf139 {ECO:0000313|Ensembl:ENSDARP00000053621,
GN   ECO:0000313|ZFIN:ZDB-GENE-080401-4};
GN   Synonyms=zgc:175173 {ECO:0000313|EMBL:AAI60659.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI60659.1};
RN   [1] {ECO:0000313|EMBL:AAI60659.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAI60659.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000053621}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053621};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000053621, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000053621,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; CABZ01067086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC160659; AAI60659.1; -; mRNA.
DR   RefSeq; NP_001116520.1; NM_001123048.1.
DR   RefSeq; XP_005173774.1; XM_005173717.3.
DR   UniGene; Dr.119244; -.
DR   STRING; 7955.ENSDARP00000111113; -.
DR   Ensembl; ENSDART00000053622; ENSDARP00000053621; ENSDARG00000036929.
DR   GeneID; 100144552; -.
DR   KEGG; dre:100144552; -.
DR   CTD; 11236; -.
DR   ZFIN; ZDB-GENE-080401-4; rnf139.
DR   eggNOG; KOG0802; Eukaryota.
DR   eggNOG; COG5243; LUCA.
DR   GeneTree; ENSGT00530000062938; -.
DR   HOGENOM; HOG000267029; -.
DR   HOVERGEN; HBG053146; -.
DR   KO; K15703; -.
DR   OMA; RIRFPDI; -.
DR   OrthoDB; EOG091G020N; -.
DR   TreeFam; TF318635; -.
DR   Reactome; R-DRE-901032; ER Quality Control Compartment (ERQC).
DR   Proteomes; UP000000437; Chromosome 19.
DR   Bgee; ENSDARG00000036929; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd00162; RING; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025754; TRC8_N_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR011016; Znf_RING-CH.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13705; TRC8_N; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00744; RINGv; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00560408};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|SAAS:SAAS00560408};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00560408}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     45     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     94       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    114    134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    141    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    315    333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    345    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    408    434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    479       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      537    576       RING-type. {ECO:0000259|PROSITE:PS50089}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       537    575       ismart:RING [T]
FT   MYHIT        14    506       ipfam:TRC8_N [T]
FT   MYHIT       536    575       ipfam:zf-RING_2 [T]
FT   MYHIT       537    576       iprf:ZF_RING_2 [T]
FT   MYHIT       536    576       ismart:RINGv [T]
SQ   SEQUENCE   664 AA;  74342 MW;  DDE55915183964F7 CRC64;
     MASAHGRLGQ HFLAVLDVVL RVPSIFIIDA ILNSYSDPGT GWSGAAGRAL IRALGIVVSG
     VVLVLSQKSL FKFYTLFMAV LLGAASVLVN YYATAHADFY SAYNSAAVLP RDGPTLWLAL
     ALMQLLLGLG YVALLRVRSV CAALLLLDIM APLWGLILEL PADMKQVLAI ASGVILATHA
     ALNLLLKLKW FYYSCRYVYL LLRHMYRIYG LQLLLEDTWK RIRFPDILRV FWLTRVTAQA
     VILLYVVRVV RSESGMQLGW DVLWDLSSNL IISGCDSTLT VLGMSAVISS LAHYLGLSIL
     AFIGSTEEED KRLGFVAPVL FFILALQTGL SGLDPEERLV RLSRNMCLLL TAILHFIHGM
     TDPVLMSLSA SHVSSVRRHV PVLLVSLVLF TLPVLLSFLL WHHYALNTWL FAVTAFCIEL
     CLKVLVSLTV YALFMMDGFY NVLWEKLDDY VYYVRSTGNV IEFIFGVIMF GNGAYTMMFE
     SGSKIRACMM CLHAYFNIYL QAKNGWKTFI NRRTAVKKIN SLPEVRGSRL RDIEDVCAIC
     YQEFGSSARI TPCSHYFHAL CLRKWLYIQD TCPMCHQRVY IEDDTSERST FSNNNGYGAA
     GQERAEFEEN EGGAEDGVAA AGAEPENELL EDNDSIEYDE EEWGTQPGVT LIEEDYINDD
     TDSN
//