ID B0UXS6_DANRE Unreviewed; 643 AA.
AC B0UXS6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 10-MAY-2017, entry version 88.
DE SubName: Full=Heat shock cognate 70-kd protein, tandem duplicate 1 {ECO:0000313|Ensembl:ENSDARP00000109199};
DE SubName: Full=Zgc:174006 protein {ECO:0000313|EMBL:AAI60648.1};
GN Name=mcm5 {ECO:0000313|ZFIN:ZDB-GENE-021209-1};
GN Synonyms=hsp70.1 {ECO:0000313|Ensembl:ENSDARP00000109199,
GN ECO:0000313|ZFIN:ZDB-GENE-990415-91},
GN zgc:174006 {ECO:0000313|EMBL:AAI60648.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000109199, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|EMBL:AAI60648.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI60648.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000109199, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109199,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000109199}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109199};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|RuleBase:RU003322}.
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DR EMBL; FP016243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC160648; AAI60648.1; -; mRNA.
DR RefSeq; XP_005163979.1; XM_005163922.3.
DR UniGene; Dr.75519; -.
DR STRING; 7955.ENSDARP00000109199; -.
DR Ensembl; ENSDART00000124762; ENSDARP00000109199; ENSDARG00000029688.
DR GeneID; 100126123; -.
DR KEGG; dre:100126123; -.
DR CTD; 100126123; -.
DR ZFIN; ZDB-GENE-990415-91; hsp70.1.
DR ZFIN; ZDB-GENE-021209-1; mcm5.
DR eggNOG; KOG0101; Eukaryota.
DR eggNOG; COG0443; LUCA.
DR GeneTree; ENSGT00870000136409; -.
DR HOGENOM; HOG000228135; -.
DR HOVERGEN; HBG051845; -.
DR KO; K03283; -.
DR OrthoDB; EOG091G03SF; -.
DR TreeFam; TF105042; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000029688; -.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0005634; C:nucleus; ISS:AgBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:ZFIN.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
DR GO; GO:0046686; P:response to cadmium ion; IEP:ZFIN.
DR GO; GO:0009408; P:response to heat; IDA:ZFIN.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IDA:ZFIN.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C.
DR InterPro; IPR029047; HSP70_peptide-bd.
DR InterPro; IPR013126; Hsp_70_fam.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|RuleBase:RU003322};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 336 350 ipat:HSP70_3 [T]
FT MYHIT 11 18 ipat:HSP70_1 [T]
FT MYHIT 199 212 ipat:HSP70_2 [T]
FT MYHIT 8 614 ipfam:HSP70 [T]
SQ SEQUENCE 643 AA; 70442 MW; C3418906DFCB6962 CRC64;
MSSPKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ
VAMNPNNTVF DAKRLIGRRF DDPVVQSDMK HWSFKVVSDG GKPKVAVEHK GENKTFNPEE
ISSMVLVKMK EIAEAYLGQK VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA
AAIAYGLDKG KSSERNVLIF DLGGGTFDVS ILTIEDGIFE VKATAGDTHL GGEDFDNRMV
NHFVEEFKRK HKKDISQNKR ALRRLRTACE RAKRTLSSSS QASIEIDSLY EGIDFYTSIT
RARFEELCSD LFRGTLDPVE KALKDAKMDK AQIHDIVLVG GSTRIPKIQK LLQDFFNGRE
LNKSINPDEA VAYGAAVQAA ILMGDTSGNV QDLLLLDVAP LSLGIETAGG VMTALIKRNT
TIPTKQTQTF TTYSDNQPGV LIQVFEGERA MTKDNNLLGK FELTGIPPAP RGVPQIEVTF
DIDANGILNV SAADKSTGKQ NKITITNDKG RLSKEEIERM VQEADKYKAE DDLQREKISA
KNSLESYAFN MKNSVEDDNL KGKISEEDKK RVIEKCNEAV SWLENNQLAD KEEYEHQLKE
LEKVCNPVIS KLYQGGMPAG GCGAQARGAS GASAQGPTIE EVD
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