ID A8KBR2_DANRE Unreviewed; 218 AA.
AC A8KBR2;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 10-MAY-2017, entry version 56.
DE SubName: Full=RAB guanine nucleotide exchange factor (GEF) 1 {ECO:0000313|Ensembl:ENSDARP00000090600};
DE SubName: Full=Zgc:65944 protein {ECO:0000313|EMBL:AAI54213.1};
GN Name=rabgef1 {ECO:0000313|Ensembl:ENSDARP00000090600,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1486};
GN ORFNames=zgc:65944 {ECO:0000313|EMBL:AAI54213.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI54213.1};
RN [1] {ECO:0000313|EMBL:AAI54213.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAI54213.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000090600}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090600};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000090600, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090600,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
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DR EMBL; AL935293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC154212; AAI54213.1; -; mRNA.
DR UniGene; Dr.123825; -.
DR UniGene; Dr.9342; -.
DR STRING; 7955.ENSDARP00000112905; -.
DR Ensembl; ENSDART00000099827; ENSDARP00000090600; ENSDARG00000014430.
DR ZFIN; ZDB-GENE-040426-1486; rabgef1.
DR eggNOG; KOG2319; Eukaryota.
DR eggNOG; KOG3173; Eukaryota.
DR eggNOG; ENOG410YGAZ; LUCA.
DR GeneTree; ENSGT00530000063341; -.
DR Reactome; R-DRE-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000014430; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR002653; Znf_A20.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Proteomics identification {ECO:0000213|PeptideAtlas:A8KBR2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1 101 VPS9. {ECO:0000259|PROSITE:PS51205}.
FT DOMAIN 13 47 A20-type. {ECO:0000259|PROSITE:PS51036}.
FT COILED 147 181 {ECO:0000256|SAM:Coils}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 13 47 iprf:ZF_A20 [T]
FT MYHIT 57 96 ipfam:VPS9 [T]
FT MYHIT 1 101 iprf:VPS9 [T]
FT MYHIT 17 40 ipfam:zf-A20 [T]
FT MYHIT 16 40 ismart:ZnF_A20 [T]
SQ SEQUENCE 218 AA; 24945 MW; 9F8B26624E49CEF5 CRC64;
MSQRSERRGI HVDQSELLCK KGCGYYGNAA WQGLCSKCWR DEYQKARQRQ IQDDWALQSN
IQYITRFCNP SRLMTGEDGY YFTNLCCAVA FIEKLDAQSL NLSPEDFERY MSGQASPRRQ
DDPAGWPQSG SRVNPVLTQI QHNLSVLSSL EKRQQQVIEG AQSLEAELTE WQESVAREVQ
EILERYPLDI KPRASAIDAE NVENDRLPPP LQPQVFAG
//
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