Legends: 1, Helicase ATP-binding. {ECO:0000259|PROSITE:PS51192}; 2, Helicase C-terminal. {ECO:0000259|PROSITE:PS51194}; 3, iprf:HELICASE_CTER [T]; 4, ipfam:Helicase_C [T]; 5, iprf:HELICASE_ATP_BIND_1 [T]; 6, ismart:HELICc [T]; 7, ismart:DEXDc [T]; 8, ipfam:DEAD [T].
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ID A8BT20_GIAIC Unreviewed; 1594 AA.
AC A8BT20;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 10-MAY-2017, entry version 46.
DE SubName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase, putative {ECO:0000313|EMBL:EDO77336.1};
GN ORFNames=GL50803_9352 {ECO:0000313|EMBL:EDO77336.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia
OS lamblia).
OC Eukaryota; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO77336.1, ECO:0000313|Proteomes:UP000001548};
RN [1] {ECO:0000313|EMBL:EDO77336.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J.,
RA Davids B.J., Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E.,
RA Huse S.M., Kim U.U., Lasek-Nesselquist E., Manning G., Nigam A.,
RA Nixon J.E., Palm D., Passamaneck N.E., Prabhu A., Reich C.I.,
RA Reiner D.S., Samuelson J., Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:EDO77336.1}.
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DR EMBL; AACB02000042; EDO77336.1; -; Genomic_DNA.
DR RefSeq; XP_001705010.1; XM_001704958.1.
DR ProteinModelPortal; A8BT20; -.
DR STRING; 184922.XP_001705010.1; -.
DR EnsemblProtists; EDO77336; EDO77336; GL50803_9352.
DR GeneID; 5697855; -.
DR KEGG; gla:GL50803_9352; -.
DR EuPathDB; GiardiaDB:GL50803_9352; -.
DR eggNOG; KOG0951; Eukaryota.
DR eggNOG; COG1204; LUCA.
DR InParanoid; A8BT20; -.
DR Proteomes; UP000001548; Unassembled WGS sequence.
DR GO; GO:0030529; C:intracellular ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004004; F:ATP-dependent RNA helicase activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010501; P:RNA secondary structure unwinding; IBA:GO_Central.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EDO77336.1};
KW Complete proteome {ECO:0000313|Proteomes:UP000001548};
KW Helicase {ECO:0000313|EMBL:EDO77336.1};
KW Hydrolase {ECO:0000313|EMBL:EDO77336.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EDO77336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Ribonucleoprotein {ECO:0000313|EMBL:EDO77336.1};
KW Viral nucleoprotein {ECO:0000313|EMBL:EDO77336.1};
KW Virion {ECO:0000313|EMBL:EDO77336.1}.
FT DOMAIN 245 438 Helicase ATP-binding.
FT {ECO:0000259|PROSITE:PS51192}.
FT DOMAIN 452 656 Helicase C-terminal.
FT {ECO:0000259|PROSITE:PS51194}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 452 656 iprf:HELICASE_CTER [T]
FT MYHIT 480 610 ipfam:Helicase_C [T]
FT MYHIT 734 1025 ipfam:Sec63 [T]
FT MYHIT 245 438 iprf:HELICASE_ATP_BIND_1 [T]
FT MYHIT 524 612 ismart:HELICc [T]
FT MYHIT 734 1051 ismart:Sec63 [T]
FT MYHIT 233 450 ismart:DEXDc [T]
FT MYHIT 239 424 ipfam:DEAD [T]
SQ SEQUENCE 1594 AA; 177309 MW; 552026F4F889390C CRC64;
MQLLQLSLAT LANSLSFFKG KISPSLMTSF ITQSPGIHKA SKVLFLLERI LGPQDDEELY
LAITDVLAAL NKESKDIGVS YLVNVFGDVD PDAAALIGDL LDAAFECQIE LAELLDQGMI
NREKNQKKQC PPDAHLSSIL CNEVRQYFSD FLTSDTLPHG QLSLPGPISN KLTGSDECAL
VALPPPEPTV TAYGNRTEYS LLWETKHANE TVSITSVLVR LQMDLAFGRV YGSITTFNSV
QMRVVDPIFN GGNTLVAAPT GAGKTNIALW AMICLLHTSR YKCRPAQLVV YVAPLKALVH
EILSQLESSF QRLPKEYTAT ICEYTGEESI SLNTISSLLH CPQTTTALVI LVATPEKLDV
FTSKLTGEDF QLIRNRLALI VFDELHLIGD HTRGSVIEEL VLRFHRHYQE AMLLALSATI
PNVQQIADFL RCASSNTLAF DSSYRAVSLQ VTVCELHYKH SEESYLRTTR EGFLHSIIPK
QLSKGSILLF THTRRDAERL AIQLQAKLDT TNYSNAYAEK SRNKRLYSLL STNSAVLFHH
AGLTRTDRYL VEELFAEKKI SILVSTATLA WGVNMPAHTV IILGTKVYAD SCWEDLSFAD
ILQMAGRAGR PSFDTNGECF IIPSANDAYR CLTIFSNRFN IESSFLTSHT ALEKLSKLII
TEAFLSAHVF VDELVQIVQS SLFAVQLFER LPNSLNGSQI ITDIVSTLLD CCCDVSLLEK
KLDDSCPHLL QYHPTPLAQL CVKYYVSPFT IVRSNAVLSQ SPIDSIQQAL LLIAMSHEYA
SIFVRADEGF ELTSLEEYTP IRYPPFVTNQ GLGKICLLLQ VYISTGPCYG TTSVAFSSLS
LMSDYASIIA SAPRITGCLR ELACLLIQSK SHQALTRLYC MLQSRCWPAF LFVREVLSNP
LFKFDFLSPE YILWIEQLEL KQFSPNVLRR LTVDQLSQII VSPDDRTPLD KRQLSHLRTA
IVGYPILRGK IVTLCQLDPK HYEVRFHCCL IGSQTILRCS EQTFSLHCAI EAEEKTLKAI
SLSIQLNEEL DVTLRFSATA ELWVCNMHLY LEELLFATSS IRIDLVSADP NKSLVAGVSI
KECSGNEISA ITAHVETTIA NLGRASGLSS GSDSVFIAGN CLYLQQAEML SSILSFIRDV
SASYKVDALI VGSVGGISGQ LARENNIPYM NTCTVYKEID KLFTRPTAII IPSIAELAEP
IGYVLELLLM KLIRKDTNLP ILVISFSIAL ADHSIVALSL FLNSKSFVIN GPDNLFTQTV
PSHAYTVSPS TLCDDPSSVH NVYEALHIVD DDPEVSMLTP FFLCQFLMMC ATTGTIYITR
NECITSATKG TNIQYLKSQL HTADGLFMLI SEHSQDFYDK GFDYIAESII TTDISQSYLY
FSFSILPGQY LNYKTMVNYH PKPEKEDLLR EEDAMLDRLS DWISEELIAL EKNATALFRA
WKDDSHGMDC SFNTLNSFSC LSMVTTRLCI VLDADREQLA KSSWFLALSQ SIHNLSLLLL
CASGVYGNEL TNYIQYEKAL SSQKDLDIEK AILKILASMV DACAESRVYA LLVALTSLAL
RVHKSGDQAV LEDTILSGQL ERLLRNTLLI DLHT
//
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