ID A4IG39_DANRE Unreviewed; 473 AA.
AC A4IG39;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 10-MAY-2017, entry version 87.
DE SubName: Full=Igsf21b {ECO:0000313|EMBL:AJG06020.1};
DE SubName: Full=Immunoglobin superfamily, member 21b {ECO:0000313|Ensembl:ENSDARP00000094963};
DE SubName: Full=Zgc:162186 protein {ECO:0000313|EMBL:AAI34917.1};
DE SubName: Full=cDNA, clone cssl:d0188 {ECO:0000313|EMBL:CAM73206.1};
GN Name=igsf21b {ECO:0000313|Ensembl:ENSDARP00000094963,
GN ECO:0000313|ZFIN:ZDB-GENE-070424-59};
GN ORFNames=zgc:162186 {ECO:0000313|EMBL:AAI34917.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI34917.1};
RN [1] {ECO:0000313|EMBL:CAM73206.1}
RP NUCLEOTIDE SEQUENCE.
RA Bushell K.M., Sollner C., Bockett N., Wright G.J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAI34917.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAI34917.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000094963}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000094963};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000094963, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000094963,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|EMBL:AJG06020.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26190107; DOI=10.1016/j.celrep.2015.06.047;
RA Gao X., Metzger U., Panza P., Mahalwar P., Alsheimer S., Geiger H.,
RA Maischein H.M., Levesque M.P., Templin M., Sollner C.;
RT "A Floor-Plate Extracellular Protein-Protein Interaction Screen
RT Identifies Draxin as a Secreted Netrin-1 Antagonist.";
RL Cell Rep. 12:694-708(2015).
CC -!- INTERACTION:
CC A8BBG8:elfn2a; NbExp=2; IntAct=EBI-2263527, EBI-2269342;
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DR EMBL; CR548634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR847529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC134916; AAI34917.1; -; mRNA.
DR EMBL; KM655674; AJG06020.1; -; mRNA.
DR EMBL; CU458945; CAM73206.1; -; mRNA.
DR RefSeq; NP_001103943.1; NM_001110473.1.
DR UniGene; Dr.85351; -.
DR IntAct; A4IG39; 1.
DR STRING; 7955.ENSDARP00000094963; -.
DR Ensembl; ENSDART00000104188; ENSDARP00000094963; ENSDARG00000056084.
DR GeneID; 567714; -.
DR KEGG; dre:567714; -.
DR CTD; 567714; -.
DR ZFIN; ZDB-GENE-070424-59; igsf21b.
DR eggNOG; ENOG410IFDU; Eukaryota.
DR eggNOG; ENOG410XPIE; LUCA.
DR GeneTree; ENSGT00390000002421; -.
DR HOGENOM; HOG000261657; -.
DR HOVERGEN; HBG061499; -.
DR OMA; SGAPTHE; -.
DR OrthoDB; EOG091G096X; -.
DR TreeFam; TF331223; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000056084; -.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
FT CHAIN 21 473 {ECO:0000256|SAM:SignalP}.
FT /FTId=PRO_5010102892.
FT DOMAIN 35 128 Ig-like (immunoglobulin-like).
FT {ECO:0000259|PROSITE:PS50835}.
FT DOMAIN 342 432 Ig-like (immunoglobulin-like).
FT {ECO:0000259|PROSITE:PS50835}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 346 434 ismart:IG [T]
FT MYHIT 342 432 iprf:IG_LIKE [T]
FT MYHIT 27 137 ismart:IG [T]
FT MYHIT 35 128 iprf:IG_LIKE [T]
FT MYHIT 32 120 ipfam:V-set [T]
FT MYHIT 317 323 ipat:IG_MHC [T]
SQ SEQUENCE 473 AA; 53139 MW; 8270752CCAA44918 CRC64;
MSVITLSLLL CADLLDFVIG YLTVTIEPLP PVVMGDTVTL KCNFRTDGNL REIVWFRVTE
GGTSKQKIFT YDAMYNTNFS HMEDFRRRED LVYQSTVRLP EVQMEDDGPY ECHVGIYDRA
SREKVVLASG SITLNVMSPP KSIFVEAANQ PARFNRYEAQ NFTLVCIVTG GKPAPVVYFK
RDGEVIEVHP FASSEKVENR GLLAPKDNQP LISRELDDTK VQKSLSFMGP YSEPVRLDKD
RPQRSYTSGA PTHEEPSPTT EVIPETVISR EFPRWVLSSS PLYFFNQTQS ELHDGTLEVQ
AMLTWHLNPQ LDNEALFSCE VKHPALSMPM KAEVTLSAPK GPKLSVAPSR AKVGDTVRIK
VEGFQMGPKA NEVFPEPLFT WTRVGGPLLD GSEERFGKEL VLERVPAELN GSMYRCTVQN
PLGSTNTHTR LIVFENPKIK KEPTQMNFGN SARDMLGPSL MMMMLLSLTL EFT
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