user: GUEST
 width: 600
MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).

Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionSubName: Full=ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100) {ECO:0000313|EMBL:CAM69695.1};
MyHits logo
MyHits synonymsA4I4I4_LEIIN , A4I4I4 , B6F307D9E678283D
match map segment
ipfam:Clp_N ismart:ClpB_D2-small ipfam:AAA_2 ipfam:Clp_N ismart:AAA ismart:AAA ipfam:AAA ipfam:ClpB_D2-small ipat:CLPAB_2 ipat:CLPAB_1  
Legends: 1, AAA. {ECO:0000259|SMART:SM00382}; 2, ClpB_D2-small. {ECO:0000259|SMART:SM01086}; 3, COILED {ECO:0000256|SAM:Coils}; 4, ipfam:Clp_N [T]; 5, ismart:ClpB_D2-small [T]; 6, ipfam:ClpB_D2-small [T]; 7, ipat:CLPAB_2 [T]; 8, ipat:CLPAB_1 [T]. 
ID   A4I4I4_LEIIN            Unreviewed;       867 AA.
AC   A4I4I4;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   10-MAY-2017, entry version 69.
DE   SubName: Full=ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100) {ECO:0000313|EMBL:CAM69695.1};
GN   ORFNames=LINJ_29_1360 {ECO:0000313|EMBL:CAM69695.1};
OS   Leishmania infantum.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671 {ECO:0000313|Proteomes:UP000008153};
RN   [1] {ECO:0000313|EMBL:CAM69695.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69695.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H.,
RA   Chillingworth T., Hance Z., Jagels K., Moule S., Ormond D., Rutter S.,
RA   Sqaures R., Whitehead S., Rabbinowitsch E., Arrowsmith C., White B.,
RA   Thurston S., Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D.,
RA   Depledge D.P., Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O.,
RA   Barrell B., Cruz A.K., Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM69695.1, ECO:0000313|Proteomes:UP000008153}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5 {ECO:0000313|EMBL:CAM69695.1,
RC   ECO:0000313|Proteomes:UP000008153};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; FR796461; CAM69695.1; -; Genomic_DNA.
DR   RefSeq; XP_001466653.1; XM_001466616.1.
DR   ProteinModelPortal; A4I4I4; -.
DR   STRING; 435258.XP_001466653.1; -.
DR   EnsemblProtists; CAM69695; CAM69695; LINJ_29_1360.
DR   GeneDB; LinJ.29.1360:pep; -.
DR   GeneID; 5070688; -.
DR   KEGG; lif:LINJ_29_1360; -.
DR   eggNOG; KOG1051; Eukaryota.
DR   eggNOG; COG0542; LUCA.
DR   InParanoid; A4I4I4; -.
DR   KO; K03695; -.
DR   OMA; IAIHILR; -.
DR   Proteomes; UP000008153; Chromosome 29.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1780.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004176; Clp_N.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81923; SSF81923; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008153};
KW   Hydrolase {ECO:0000313|EMBL:CAM69695.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU004432};
KW   Protease {ECO:0000313|EMBL:CAM69695.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW   Stress response {ECO:0000313|EMBL:CAM69695.1}.
FT   DOMAIN      197    342       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      597    768       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      767    858       ClpB_D2-small.
FT                                {ECO:0000259|SMART:SM01086}.
FT   COILED      411    453       {ECO:0000256|SAM:Coils}.
FT   COILED      461    498       {ECO:0000256|SAM:Coils}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        21     58       ipfam:Clp_N [T]
FT   MYHIT       767    858       ismart:ClpB_D2-small [T]
FT   MYHIT       596    761       ipfam:AAA_2 [T]
FT   MYHIT        94    143       ipfam:Clp_N [T]
FT   MYHIT       197    342       ismart:AAA [T]
FT   MYHIT       597    768       ismart:AAA [T]
FT   MYHIT       202    315       ipfam:AAA [T]
FT   MYHIT       767    847       ipfam:ClpB_D2-small [T]
FT   MYHIT       631    649       ipat:CLPAB_2 [T]
FT   MYHIT       293    305       ipat:CLPAB_1 [T]
SQ   SEQUENCE   867 AA;  96957 MW;  B6F307D9E678283D CRC64;
     MTTQQPEWTQ AASDLMARTA ALARKKANGY LDPVHLAYVM FEDENSLASR VVRKLGAASV
     KDGLEARVDA IPTQMPAPTQ PRPNSDMMRV MNTAEQERVA LGDTLMAADH FLLALHESKE
     VGRILDAAGA GKKAIRATLL EMRKGKKINS DFQDDNYESL NKYAVDLCKQ AEDGKLDPVI
     GRADEILRTI RVLSRRTKNN PVLIGEPGVG KTAIVEGIAQ QVVRGDVPDT LSGIRIFSLD
     MGALIAGAKY RGEFEERLKA VLNEVKESDN KIILFIDEIH LVLGAGKSDG AMDAANLLKP
     LLARGELRTI GATTLEEYRQ YVEKDAAFER RFMPVQVNEP SVEECTSILR GLKDRYEQHH
     GVQITDKAVV VAAQLAGRYI TNRFLPDKAI DLIDEACANV RVTLSSRPAE IDALERKKRQ
     LEIEEKALQR DKDASAKERL KAVKAEIQKV EEKLGPLLAK YEQERGRIDE LQATQAKLDE
     KKVKLERAER MRDMETAADL KYNVIPILQD RIRSLKEEIE KQKATMLQGT VTETDIATVV
     SRWTNIPVTK LSQTERERLL HLADQLHLRV KGQDEAVSRV AEAILRSRAG LARSDRPTGS
     FLFLGPTGVG KTELSKAVAS ELFDDAKYMV RLDMSEYMEQ HSVARLIGAP PGYVGHEEGG
     QLTEPVRRRP YTVVLLDEVE KAHPNVFNVL LQVLDDGRLT DSHGRTVNFC NTIIIMTSNL
     GAQYLQNMDT SPKAYEVAQT QVMGEVRKFF RPEFINRLDD IILFRSLGLK EMTGIIDLIT
     EELNGRLKDQ SIRVSLTEEA KNYVLESAFD ADMGARPLRR WVEKNITTEL SRMIISQELS
     PNSTVKVTLS SNHKKLSFSV KRTAAQT
//