Entry euk:A0A1B0GWA0_HUMAN

ID   A0A1B0GWA0_HUMAN        Unreviewed;      1128 AA.
AC   A0A1B0GWA0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   10-MAY-2017, entry version 7.
DE   SubName: Full=Zinc finger protein 654 {ECO:0000313|Ensembl:ENSP00000490842};
GN   Name=ZNF654 {ECO:0000313|Ensembl:ENSP00000490842};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490842, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000490842}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000490842}.
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DR   EMBL; AC119733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC128650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016862279.1; XM_017006790.1.
DR   UniGene; Hs.591650; -.
DR   UniGene; Hs.661116; -.
DR   Ensembl; ENST00000636215; ENSP00000490842; ENSG00000175105.
DR   GeneID; 55279; -.
DR   CTD; 55279; -.
DR   HGNC; HGNC:25612; ZNF654.
DR   OpenTargets; ENSG00000175105; -.
DR   GeneTree; ENSGT00840000129803; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   ExpressionAtlas; A0A1B0GWA0; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A1B0GWA0,
KW   ECO:0000213|MaxQB:A0A1B0GWA0, ECO:0000213|PeptideAtlas:A0A1B0GWA0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN      572    599       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT   DOMAIN      815    839       C2H2-type. {ECO:0000259|PROSITE:PS50157}.
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CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       787    809       ismart:ZnF_C2H2 [T]
FT   MYHIT       789    809       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       746    771       ismart:ZnF_C2H2 [T]
FT   MYHIT       815    839       ismart:ZnF_C2H2 [T]
FT   MYHIT       815    839       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       817    839       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       844    868       ismart:ZnF_C2H2 [T]
FT   MYHIT       572    599       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       748    771       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       574    594       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       846    868       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       572    594       ismart:ZnF_C2H2 [T]
FT   MYHIT       545    566       ismart:ZnF_C2H2 [T]
FT   MYHIT      1091   1111       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   1128 AA;  127876 MW;  423D89066E84546A CRC64;
     MAEEESDQEA ERLGEELVAI VESPLGPVGL RAAGDGRGGA GSGNCGGGVG ISSRDYCRRF
     CQVVEDYAGR WQVPLPQLQV LQTALCCFTT ASASFPDECE HVQYVLSSLA VSFFELLLFF
     GRDEFYEEPL KDILGSFQEC QNHLRRYGNV NLELVTRIIR DGGPWEDPVL QAVLKAQPAS
     QEIVNKYLSS ENPLFFELRA RYLIACERIP EAMALIKSCI NHPEISKDLY FHQALFTCLF
     MSPVEDQLFR EHLLKTDCKS GIDIICNAEK EGKTMLALQL CESFLIPQLQ NGDMYCIWEL
     IFIWSKLQLK SNPSKQVFVD QCYQLLRTAT NVRVIFPFMK IIKDEVEEEG LQICVEICGC
     ALQLDLHDDP KTKCLIYKTI AHFLPNDLEI LRICALSIFF LERSLEAYRT VEELYKRPDE
     EYNEGTSSVQ NRVRFELLPI LKKGLFFDPE FWNFVMIKKN CVALLSDKSA VRFLNESTLE
     NNAGNLKRTE EQQGLDEGFD SLTDQSTGET DPDDVSGVQP KGHINTKKNL TALSTSKVDH
     NVPRHRCMLC NKEFLGGHIV RHAQAHQKKG SFACVICGRK FRNRGLMQKH LKNHVKKIQR
     QQIAAAQQDD QEVTALEEIN CSSSSISFEN GNSDSKDLEV ETLTASSEGN KEVIPEHVAE
     FIEIPISVPE DVIENVIENG SPNNSLNNVF KPLTECGDDY EEEEDEEGDY EEDDYDLNQE
     TSVIHKINGT VCHPKDIYAT DQEGNFKCPA LGCVRIFKRI GFLNKHAMTV HPTDLNVRQT
     VMKWSKGKCK FCQRQFEDSQ HFIDHLNRHS YPNVYFCLHF NCNESFKLPF QLAQHTKSHR
     IFQAQCSFPE CHELFEDLPL LYEHEAQHYL SKTPESSAQP SETILWDVQT DSNPNQEKDS
     SSNEKQTISL PVSTSKSRKE STEPKTCIES MEKKTDSLVQ NGNERSDDTV SNISLIDQKM
     PDIEPNSENN CSSSDIVNGH SEIEQTPLVS SDPALKIDTN RIRTENGSIL PSVVPQEHNT
     LPVSQAPSKP NLTSEHTSYG LILTKPYVRP LPPSYLDERY LSMPKRRKFL TDRVDACSDQ
     DNVYKKSVKR LRCGKCLTTY CNAEALEAHL AQKKCQTLFG FDSDDESA
//