ID A0A0R4IZ60_DANRE Unreviewed; 324 AA.
AC A0A0R4IZ60;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 10-MAY-2017, entry version 10.
DE SubName: Full=Zgc:136493 {ECO:0000313|Ensembl:ENSDARP00000140651};
GN ORFNames=zgc:136493 {ECO:0000313|Ensembl:ENSDARP00000140651,
GN ECO:0000313|ZFIN:ZDB-GENE-060512-216};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000140651, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000140651, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140651,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000140651}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140651};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000140651}.
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DR EMBL; CR391941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSDART00000163864; ENSDARP00000140651; ENSDARG00000029259.
DR ZFIN; ZDB-GENE-060512-216; zgc:136493.
DR GeneTree; ENSGT00510000046913; -.
DR Proteomes; UP000000437; Chromosome 16.
DR ExpressionAtlas; A0A0R4IZ60; baseline.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IZ60};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 45 322 2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
FT DOMAIN 112 291 2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 112 291 ipfam:2-Hacid_dh_C [T]
FT MYHIT 45 322 ipfam:2-Hacid_dh [T]
FT MYHIT 151 178 ipat:D_2_HYDROXYACID_DH_1 [T]
SQ SEQUENCE 324 AA; 35904 MW; F1F62CB9794F83A4 CRC64;
MEKPCILTKT LGAPGSIYKC FEPCIDKHFT IIPYERFVQR KEDFAAKIQA VFSWGPNINV
DRDLLQSLPN LKAVINGGVG VDHLDIPLIN SFGVKVSNTP HVVDNATADI GMSLMLASAR
KIIEGQHFSK FRESDDFPES TMGTDVSGAT LGIIGMGRIG YKIAKRAQGF DMKILYHNRN
RRPENEERAV GATYCASMTE LLQRSDFVMV VVNLSPQTHK LISAKEFAMM RPNSTFINIS
RGLVVDQDAL VDALLKKMIR AAALDVTYPE PLPRDHPLLS FPNVIVMPHI GTHTLETSQL
MVERMVTNAL AILNEGQLPD EVKA
//
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