Entry euk:A0A0R4IFW1_DANRE

ID   A0A0R4IFW1_DANRE        Unreviewed;      1443 AA.
AC   A0A0R4IFW1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   SubName: Full=Zgc:171445 {ECO:0000313|Ensembl:ENSDARP00000132227};
GN   ORFNames=zgc:171445 {ECO:0000313|Ensembl:ENSDARP00000132227,
GN   ECO:0000313|ZFIN:ZDB-GENE-080205-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000132227, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000132227, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132227,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000132227}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132227};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000132227}.
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DR   EMBL; BX322654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000164463; ENSDARP00000132227; ENSDARG00000076771.
DR   ZFIN; ZDB-GENE-080205-2; zgc:171445.
DR   GeneTree; ENSGT00760000118982; -.
DR   Proteomes; UP000000437; Chromosome 3.
DR   ExpressionAtlas; A0A0R4IFW1; baseline.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 2.60.40.690; -; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR011626; A2M_comp.
DR   InterPro; IPR002890; A2M_N.
DR   InterPro; IPR011625; A2M_N_2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07678; A2M_comp; 1.
DR   Pfam; PF01835; A2M_N; 1.
DR   Pfam; PF07703; A2M_N_2; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF10569; Thiol-ester_cl; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   SUPFAM; SSF49410; SSF49410; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IFW1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1443       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006451182.
FT   DOMAIN      478    611       A2M_N_2. {ECO:0000259|SMART:SM01359}.
FT   DOMAIN      737    826       A2M. {ECO:0000259|SMART:SM01360}.
FT   DOMAIN     1349   1438       A2M_recep. {ECO:0000259|SMART:SM01361}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       479    611       ipfam:A2M_N_2 [T]
FT   MYHIT       737    825       ipfam:A2M [T]
FT   MYHIT      1349   1438       ipfam:A2M_recep [T]
FT   MYHIT       966    974       ipat:ALPHA_2_MACROGLOBULIN [T]
FT   MYHIT      1349   1438       ismart:A2M_recep [T]
FT   MYHIT       478    611       ismart:A2M_N_2 [T]
FT   MYHIT       737    826       ismart:A2M [T]
FT   MYHIT       958    987       ipfam:Thiol-ester_cl [T]
FT   MYHIT       143    234       ipfam:A2M_N [T]
FT   MYHIT      1007   1239       ipfam:A2M_comp [T]
SQ   SEQUENCE   1443 AA;  156996 MW;  9A05BA506C016B37 CRC64;
     MEISVWKWIN LVLFFCFVDG AKLIVEAPKP IETLVTADEQ ISGPLFLVTF PSLIESGSGA
     KLCASLLKPQ GSLTITITLI DDKSAETRLV RQTTQRKLHR CFNFQAPLVN GDSVQTVRVV
     VQGQSFKMTE ERKVMFRSYL PLTFIQTDKP LYNPGQTVNF RVVTMSDKFV PLDQMYNLVV
     LEDFRNIRIN QWTNVSSVNW ILELSHVLIP EAQVGTYTLR AYIGDRIISQ SFDVKQYVLP
     KFDVTVNTLQ MYSVADAGLK VEACGKYTFG QPVPGQVLVQ VCRQPLAFIQ DTKVTSICLN
     KSMRTNNTGC ASLTLSTSSF FGTSSESNLQ NSFVVNVNLT EEGTGVVMSK STTVSITFEV
     GKVTFVDLPK FYNYGSTVNG KARISVSDFN GNPIYSKAVY LLDSSIWPNK LLFNLTTNQN
     GFAKFSLDTT SFPQADLNLV ASATPQSYFS SNSPYFTTDS QVVQLSQTDP DTPTFSDLSI
     VKLEQPLKCG TTYSVTVKYL FVGETGDYSA DIIYMGTRAS NTLTKGTVTF DLSVLAKMAP
     MVQILVYSVL PSQTVVTGSA SFDTEKCFSN QVSLQFSPAT AVPGEGNILT VSAQAGSLCG
     LSAIDQSVLI MQSGGRLSAE AVFNMLPLQS LSDYPYGAED QQDCLNVRPR RAVPTDQAYN
     AFKSVGMKIA TNLPVREPEC LKFKDLLYYR NFHGVFPFRG TGFAMAEMAP APLATAEIGG
     TRGSSVDVTI RTYFPETWIW QLALVGDSGS TSVPLTVPDT ITTWDTEAFC LSSNGFGLAP
     PALLTSFQPF FLELTLPYSI IRGEAFELVA TVFNYLLQCL KIQVTPTPSS NYTLTPINDQ
     SSSTLSTNWR KTIKWALTAS VIGTVNVTIS AEASPSQELC GDQDVTVLSR GRIDIVTRSL
     RVLAEGVERT FTRSWLLCPK GFVLSESVKI TLPTNVIQGS ASCSVSVIGD IMGRALNNLA
     NLLQMPSGCG EQNMIILAPN VYILRYLTVT AQLTPAVQDT ATSYLLTGYQ GELNYRHSDG
     SFSTFGYDAS NTWLTAFVMR TFGLARSFTY IDPNVLKGAK DWLISTQGSD GCFVQQGTLY
     HNDMKGGVGD NVTMTGYIVA SLLEIGVPAT DPVIMKALSF LRPLVGNLGN TYVTALLAYT
     FSLAGETSTR AQLLNSLRNT AISEGTTLHW SQTTSGDTLA VEISAYVLLA VLTVQPVTTA
     NLGYANRIVN WIVAQQNPYG GFSSTQDTVV ALQALALYAA QAFTPGGSST VTVQSSVPAG
     DIFNFAVTPN NRLLYQRNSL NNFPGTYSVV ARGSACASVQ VACFYNVPTP VTVAKTLSVV
     AKVTGDCQAA PVNLMLTFTV KYNGRKPATN MVLVDIKVLS GFTADTSLLG SPPNFAPLVQ
     RVDSNGDHVL VYLQEVPKGV PVTFSIQLTQ TVAVQNLKPA VINIYDYYQR SDKFETTYKS
     PCP
//