ID A0A0N4SV59_MOUSE Unreviewed; 192 AA.
AC A0A0N4SV59;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 3.
DT 10-MAY-2017, entry version 11.
DE SubName: Full=Olfactory receptor 449 {ECO:0000313|Ensembl:ENSMUSP00000144965};
DE Flags: Fragment;
GN Name=Olfr449 {ECO:0000313|Ensembl:ENSMUSP00000144965,
GN ECO:0000313|MGI:MGI:3030283};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000144965, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000144965, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144965,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000144965}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000144965};
RG Ensembl;
RL Submitted (DEC-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane
CC {ECO:0000256|SAAS:SAAS00521146}; Multi-pass membrane protein
CC {ECO:0000256|SAAS:SAAS00521146}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00591716}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000144965}.
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DR EMBL; AC121317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSMUST00000203135; ENSMUSP00000144965; ENSMUSG00000049168.
DR MGI; MGI:3030283; Olfr449.
DR GeneTree; ENSGT00800000124041; -.
DR Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR Proteomes; UP000000589; Chromosome 6.
DR ExpressionAtlas; A0A0N4SV59; baseline.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|SAAS:SAAS00521172};
KW Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000256|SAAS:SAAS00529918};
KW Membrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAAS:SAAS00521172, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|SAAS:SAAS00521184};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000256|SAAS:SAAS00529918};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|SAAS:SAAS00521184};
KW Transducer {ECO:0000256|RuleBase:RU000688,
KW ECO:0000256|SAAS:SAAS00529918};
KW Transmembrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25 48 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60 79 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99 120 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140 162 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 41 192 G_PROTEIN_RECEP_F1_2.
FT {ECO:0000259|PROSITE:PS50262}.
FT NON_TER 192 192 {ECO:0000313|Ensembl:ENSMUSP00000144965}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 41 192 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 110 126 ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ SEQUENCE 192 AA; 21920 MW; 532F14CA249E6857 CRC64;
MDVDNQTRVT KFILVGFPGS LSMRAAVFLM FLVAYILTVA ENVIIILLVQ QNRPLHKPMY
FFLANLSFLE TWYISVTVPK LLFSFWSMSN SISFTHCMIQ LYFFIALMCT ECVLLAAMAY
DRYVAICRPL HYPTIMSHGL CFRLALGSWV IGFGISLAKI YFISRLSFCG PNVINHFFCD
ISPVLNLSCT DM
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