ID A0A0H2UJG8_DANRE Unreviewed; 269 AA.
AC A0A0H2UJG8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 15-MAR-2017, entry version 9.
DE SubName: Full=Pim proto-oncogene, serine/threonine kinase,-related 103 {ECO:0000313|Ensembl:ENSDARP00000132067};
GN Name=pimr103 {ECO:0000313|Ensembl:ENSDARP00000132067,
GN ECO:0000313|ZFIN:ZDB-GENE-081104-107};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000132067, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000132067, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132067,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000132067}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132067};
RG Ensembl;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC {ECO:0000256|RuleBase:RU000304}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000132067}.
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DR EMBL; CR354547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSDART00000170611; ENSDARP00000132067; ENSDARG00000095525.
DR ZFIN; ZDB-GENE-081104-107; pimr103.
DR GeneTree; ENSGT00760000119045; -.
DR OMA; FCAKGHI; -.
DR Proteomes; UP000000437; Chromosome 8.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR017348; PIM1/2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF037993; STPK_Pim-1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR037993-2,
KW ECO:0000256|RuleBase:RU000304};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Kinase {ECO:0000256|RuleBase:RU000304};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037993-2,
KW ECO:0000256|RuleBase:RU000304};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW Transferase {ECO:0000256|RuleBase:RU000304}.
FT DOMAIN 11 267 Protein kinase.
FT {ECO:0000259|PROSITE:PS50011}.
FT ACT_SITE 144 144 Proton acceptor.
FT {ECO:0000256|PIRSR:PIRSR037993-1}.
FT BINDING 40 40 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 97 97 ATP; via carbonyl oxygen.
FT {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 104 104 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 140 152 ipat:PROTEIN_KINASE_ST [T]
FT MYHIT 17 40 ipat:PROTEIN_KINASE_ATP [T]
FT MYHIT 11 267 iprf:PROTEIN_KINASE_DOM [T]
FT MYHIT 14 267 ipfam:Pkinase [T]
FT MYHIT 11 267 ismart:S_TKc [T]
SQ SEQUENCE 269 AA; 30534 MW; B3975B3C6E1957F9 CRC64;
MTSQVINSCH YLIDDMLGEG SFGTVYKGRR LHDDLKVAVK FVTKTEDVEY ICISGHSEPF
PLEVALLILA HGVSSVPEII QLLDWQDQED HYIMVLEYPS PCEDLYAFTE SYGGSISEGL
ARVVMQQATQ AAYMCCRNGV LHRDIKLENL LINKETHKVK LIDFGCGDLL KKLPYDTFAG
TLEYCPPEFE ETGEYNGKPA TVWSLGILLF VLVCEDFPNP QELHMINENN FSKAGLSDEC
CQLISCCLQQ KPEQRIQLKE ILLHEWFKV
//
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